Abstract:
:PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutations in the paired domain of PAX9, a three-nucleotide deletion (73-75 delATC) and a missense mutation (C146T), in two unrelated Japanese patients with non-syndromic tooth agenesis. The individual with the 73-75del ATC mutation was missing all maxillary molars and mandibular second and third molars. The individual with the C146T mutation was missing the mandibular central incisors, maxillary second premolars, and first molars, along with all second and third molars. Both mutations affected amino acids that are highly conserved among different species and are critical for DNA binding. When both mutants were transfected to COS7 cells, nuclear localization of PAX9 proteins was not affected. However, reduced expression of the mutant proteins and almost no transcriptional activity of the target BMP4 gene were observed, suggesting haploinsufficiency of PAX9 as the cause of non-syndromic tooth agenesis.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Mitsui SN,Yasue A,Masuda K,Watanabe K,Horiuchi S,Imoto I,Tanaka Edoi
10.1177/0022034513519801subject
Has Abstractpub_date
2014-03-01 00:00:00pages
245-9issue
3eissn
0022-0345issn
1544-0591pii
0022034513519801journal_volume
93pub_type
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journal_title:Journal of dental research
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