Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro.

abstract：:Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...

journal_title：Journal of dental research

authors： Mangum JE,Crombie FA,Kilpatrick N,Manton DJ,Hubbard MJ

更新日期：2010-10-01 00:00:00

abstract：:Previous studies suggest that salivary and pulp-derived host enzymes, matrix metalloproteinases (MMPs), may be involved in dentin caries pathogenesis. To study the inhibition of acid-activated human salivary MMPs by non-antimicrobial chemically modified tetracyclines (CMTs), we used a functional activity assay with 12...

journal_title：Journal of dental research

authors： Sulkala M,Wahlgren J,Larmas M,Sorsa T,Teronen O,Salo T,Tjäderhane L

更新日期：2001-06-01 00:00:00

abstract：:The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...

journal_title：Journal of dental research

authors： Barone JP,Nancollas GH

更新日期：1978-01-01 00:00:00

abstract：:Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...

journal_title：Journal of dental research

authors： Yamakoshi Y,Kinoshita S,Izuhara L,Karakida T,Fukae M,Oida S

更新日期：2014-07-01 00:00:00

abstract：:This study was conducted to test the hypothesis that physiological changes which occur during aging increase the biological impact of fluoride and reduce the threshold of safe fluoride exposure. Four groups of rats were fed a low-fluoride diet (< 1.2 ppm) ad libitum and received 0, 5, 15, or 50 ppm fluoride in their d...

journal_title：Journal of dental research

authors： Dunipace AJ,Brizendine EJ,Zhang W,Wilson ME,Miller LL,Katz BP,Warrick JM,Stookey GK

更新日期：1995-01-01 00:00:00

abstract：:The human patched gene (PTCH) functions in both embryologic development and tumor suppression. PTCH mutations have been found in odontogenic keratocysts. However, the expression and localization of the protein product of the gene have not been determined in odontogenic tumors and cysts. We investigated 68 odontogenic ...

journal_title：Journal of dental research

authors： Barreto DC,Bale AE,De Marco L,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：:Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in...

journal_title：Journal of dental research

authors： Ohyama H,Kato-Kogoe N,Kuhara A,Nishimura F,Nakasho K,Yamanegi K,Yamada N,Hata M,Yamane J,Terada N

更新日期：2009-07-01 00:00:00

abstract：:Tooth agenesis is one of the most common developmental anomalies affecting function and esthetics. The paired-domain transcription factor, Pax9, is critical for patterning and morphogenesis of tooth and taste buds. Mutations of PAX9 have been identified in patients with tooth agenesis. Despite significant progress in ...

journal_title：Journal of dental research

authors： Wong SW,Han D,Zhang H,Liu Y,Zhang X,Miao MZ,Wang Y,Zhao N,Zeng L,Bai B,Wang YX,Liu H,Frazier-Bowers SA,Feng H

更新日期：2018-02-01 00:00:00

abstract：:Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck ca...

journal_title：Journal of dental research

authors： Victory K,Burd R,Fribley A,Sittadjody S,Arnett D,Klein RR,Limesand KH

更新日期：2011-03-01 00:00:00

abstract：:Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differ...

journal_title：Journal of dental research

authors： Kim TH,Bae CH,Lee JC,Kim JE,Yang X,de Crombrugghe B,Cho ES

更新日期：2015-03-01 00:00:00

abstract：:It has not been established whether transmission of mutans streptococci occurs between unrelated children older than 4 years of age. The aim of the study was to investigate the possible transmission of mutans streptococci genotypes from child to child in kindergarten. We studied 96 children (ages 5-6 yrs) in three San...

journal_title：Journal of dental research

authors： Doméjean S,Zhan L,DenBesten PK,Stamper J,Boyce WT,Featherstone JD

更新日期：2010-01-01 00:00:00

abstract：:The following five outlines are the results to date of the Workshop held in Rockville, Maryland, in January, 1990. The topics considered in these outlines are: (1) validation of immunological and/or nucleic acid identification probes, (2) cross-calibration of methods and/or laboratories for multi-laboratory cooperativ...

journal_title：Journal of dental research

authors： Krichevsky MI

更新日期：1991-03-01 00:00:00

abstract：:This study investigated the relevance between pulp vitality and autophagy in aged human dental pulp cells (HDPCs) and whether peroxisome proliferator-activated receptor gamma (PPARγ) affects autophagy regulation for homeostasis in the aging progress. In vivo experiments were used in human and Sprague-Dawley rat teeth ...

journal_title：Journal of dental research

authors： Lee YH,Lee HY,Kim TG,Lee NH,Yu MK,Yi HK

更新日期：2015-05-01 00:00:00

abstract：:Breastfeeding is important for health and development. Yet, the interaction between breastfeeding duration and usage of fluoridated water on caries experience has not been investigated. This study examined exposure to fluoridation as an effect modifier of the association between breastfeeding duration and caries. The ...

journal_title：Journal of dental research

authors： Ha DH,Spencer AJ,Peres KG,Rugg-Gunn AJ,Scott JA,Do LG

更新日期：2019-07-01 00:00:00

abstract：:Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic ba...

journal_title：Journal of dental research

authors： Takahashi N

更新日期：2015-12-01 00:00:00

abstract：:Selected strains of oral bacteria were analyzed for their ability to degrade wheat starch, maltose, maltotriose, and maltoheptaose. S. sanguis IUOM-11M and JC804, S. mutans 6715, S. salivarius IUOM-8, A. viscosus IUOM-62, and A. naeslundii ATCC 12104 degraded all four substrates. S. mutans NCTC 10449 degraded starch, ...

journal_title：Journal of dental research

authors： Glor EB,Miller CH,Spandau DF

更新日期：1988-01-01 00:00:00

abstract：:Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...

journal_title：Journal of dental research

authors： Roberts WE,Chase DC

更新日期：1981-02-01 00:00:00

abstract：:Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to e...

journal_title：Journal of dental research

authors： Listl S,Galloway J,Mossey PA,Marcenes W

更新日期：2015-10-01 00:00:00

abstract：:The biochemical function, adenylate energy charge (AEC), correlates with the viable count of S. mutans. AEC may be used to estimate the percent viable fraction of bacteria in dental plaque samples. An interactive computer program designed to process the AEC data is described. ...

journal_title：Journal of dental research

authors： Kemp CW

更新日期：1979-11-01 00:00:00

abstract：:The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives. In many cases, pre-conditioning the restoratives in these liquids for one week produced swelling of the polymer matrix and considerable surface damage. The result...

journal_title：Journal of dental research

authors： McKinney JE,Wu W

更新日期：1985-11-01 00:00:00

abstract：:The amount of free water in 50 samples of air-dried enamel from permanent and deciduous teeth was measured by the Karl Fischer method. Samples included both contemporary and burial specimens. The mean values obtained showed that free water constituted about 1% of enamel mass. However, the range of individual values va...

journal_title：Journal of dental research

authors： Bonte E,Deschamps N,Goldberg M,Vernois V

更新日期：1988-05-01 00:00:00

abstract：:Dental enamel formation is a remarkable example of a biomineralization process. The exact mechanisms involved in this process remain partly obscure. Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta. Mutational analyses within studied families have s...

journal_title：Journal of dental research

authors： Stephanopoulos G,Garefalaki ME,Lyroudia K

更新日期：2005-12-01 00:00:00

abstract：:With clinical oral examinations not always possible in health surveys, researchers may instead be invited to add questions to a wider health survey. In such situations, an item is needed which adequately represents both clinical and self-reported oral health. This study investigated the clinical validity of Locker's g...

journal_title：Journal of dental research

authors： Thomson WM,Mejia GC,Broadbent JM,Poulton R

更新日期：2012-11-01 00:00:00

abstract：:A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a re...

journal_title：Journal of dental research

authors： Pashley DH,Livingston MJ,Outhwaite WC

更新日期：1977-01-01 00:00:00

abstract：:Joining a brittle veneer to a strong ceramic core with an adhesive offers potential benefits over current fabrication methods for all-ceramic crowns. We tested the hypothesis that such joining can withstand subsurface radial cracking in the veneer, from enhanced flexure in occlusal loading, as well as in the core. Cri...

journal_title：Journal of dental research

authors： Lee JJ,Kwon JY,Bhowmick S,Lloyd IK,Rekow ED,Lawn BR

更新日期：2008-04-01 00:00:00

abstract：:Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1beta and tumor necrosis factor-alpha (TNF-alpha), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinas...

journal_title：Journal of dental research

authors： Beklen A,Ainola M,Hukkanen M,Gürgan C,Sorsa T,Konttinen YT

更新日期：2007-04-01 00:00:00

abstract：:The purpose of the work described here was to investigate the mechanisms involved in the binding of salivary alpha-amylase to Streptococcus gordonii NCTC 7868 (Challis). Of six types of alpha-amylase studied, only mammalian forms of the enzyme were found to bind to S. gordonii cells. Salivary alpha-amylase binding was...

journal_title：Journal of dental research

authors： Douglas CW

更新日期：1990-11-01 00:00:00

abstract：:The effect of low-level laser treatment on maxillary arch dimensions after palatal surgery was investigated in Beagle dogs at an age of 12 weeks. A total of 30 dogs was used, and they were assigned to either a control group (Group C, n = 6) or one of two experimental groups (Group L, n = 12; and group LL, n = 12). Aft...

journal_title：Journal of dental research

authors： in de Braekt MM,Van Alphen FA,Kuijpers-Jagtman AM,Maltha JC

更新日期：1991-11-01 00:00:00

abstract：:Periodontal inflammation and alveolar bone remodeling during orthodontic tooth movement are considered regional reactions. However, how systemic immune responses are involved in this regional reaction remains unclear. In this study, we explored the systemic effects of orthodontic force by focusing on the mononuclear p...

journal_title：Journal of dental research

authors： Zeng M,Kou X,Yang R,Liu D,Wang X,Song Y,Zhang J,Yan Y,Liu F,He D,Gan Y,Zhou Y

更新日期：2015-09-01 00:00:00

abstract：:The term "artificial intelligence" (AI) refers to the idea of machines being capable of performing human tasks. A subdomain of AI is machine learning (ML), which "learns" intrinsic statistical patterns in data to eventually cast predictions on unseen data. Deep learning is a ML technique using multi-layer mathematical...

journal_title：Journal of dental research

authors： Schwendicke F,Samek W,Krois J

更新日期：2020-07-01 00:00:00