Abstract:
:The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-TEGDMA applied via gastric, intradermal, and intravenous administration at dose levels well above those encountered in dental care were examined in vivo in guinea pigs and mice as a test of the hypothesis that TEGDMA reaches cytotoxic levels in mammalian tissues. 14C-TEGDMA was taken up rapidly from the stomach and small intestine after gastric administration in both species and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as 14CO2. The peak equivalent TEGDMA levels in all mouse and guinea pig tissues examined were at least 1000-fold less than known toxic levels. The study therefore did not support the hypothesis.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Reichl FX,Durner J,Hickel R,Kunzelmann KH,Jewett A,Wang MY,Spahl W,Kreppel H,Moes GW,Kehe K,Walther U,Forth W,Hume WRdoi
10.1177/00220345010800050501keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
1412-5issue
5eissn
0022-0345issn
1544-0591journal_volume
80pub_type
杂志文章abstract::Medication-related osteonecrosis of the jaw (MRONJ), although initially believed to be exclusively associated with bisphosphonates, has been implicated in recent reports with additional drugs, especially the bone antiresorptive denosumab. The pathophysiology has not been fully elucidated, and no causal association bet...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
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更新日期:2015-04-01 00:00:00
abstract::A three-month study of the chemistry of the water erosion of two forms of ASPA cement has been made. The effect of varying cement consistency and cure time was investigated. The results are discussed in terms of the known chemistry and structure of the cement. The erosion behavior is compared to that of silicate, sili...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550060501
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abstract::Previous studies have shown that fluoride affected the formation of apatite in spontaneous precipitations from unstable calcium phosphate solutions partly through its effect on the stability of such nonapatitic precursors as octacalcium phosphate, Ca8H2(PO4)6.5 H2O. The present study shows that fluoride had a comparab...
journal_title:Journal of dental research
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doi:10.1177/00220345800590021401
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journal_title:Journal of dental research
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doi:10.1177/00220345870660082301
更新日期:1987-08-01 00:00:00
abstract::Samples of dental plaque obtained from the interproximal tooth surfaces of seven young men showed considerable variation in the prevalence and anatomic site distribution of the potentially cariogenic microorganism S mutans. Multiple application of 10% SnF2 topical solution and saline solution delivered to interproxima...
journal_title:Journal of dental research
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doi:10.1177/00220345770560010301
更新日期:1977-01-01 00:00:00
abstract::The distribution of immunoglobulin-containing cells in human tonsils, salivary glands, and inflamed gingiva is described. The cellular localization of J chain indicates that this peptide is a basic gene product of B cells that is expressed only in the early phase of clonal differentiation. Gland-associated immunocytes...
journal_title:Journal of dental research
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doi:10.1177/002203457605500301011
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abstract::Direct FA staining for S mutans serotypes may be performed on smears made from plaque or strain isolates and on colonies attached to agar plates of black membrane filters. Staining with single conjugates directed to S mutans serotypes (a to e) as well as with polyvalent a-, b-, d-, f-fluorescein label and c-, e-rhodam...
journal_title:Journal of dental research
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doi:10.1177/002203457605500126011
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abstract::Wall-to-wall (WTW) polymerization contraction of filled and unfilled chemically and photo-initiated resins was studied in relation to the WTW distance. In an experimental set-up, the resins were bonded to two opposing disks, and the axial (WTW) displacement resulting from the polymerization shrinkage was measured cont...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680010701
更新日期:1989-01-01 00:00:00
abstract::Application of an incisal bite plane for as little as three d caused a significant increase in the size of the sublingual glands of rats, with some evidence of hyperplasia and hypertrophy of the acinar cells. The enlargement had few effects on salivary secretion, and the gland changes were reversible. ...
journal_title:Journal of dental research
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更新日期:1983-06-01 00:00:00
abstract::The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...
journal_title:Journal of dental research
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abstract::Cytotoxicity of fine cut amalgam was persistent until 24 hours after trituration in vitro, whereas cytotoxicity of spherical amalgam diminished more quickly. Increasing mercury content in spherical amalgam increased cytotoxicity. Possible reactions for the diminution of cytotoxicity of amalgams with time are discussed...
journal_title:Journal of dental research
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更新日期:1975-03-01 00:00:00
abstract::The surface enamel of fetal bovine teeth was stained with GBHA to indicate the position of bands of smooth-ended and ruffle-ended ameloblasts relative to the developing enamel. The boundaries of the bands were scored, under a dissecting microscope, and the bulk enamel under each band was collected. The enamel samples ...
journal_title:Journal of dental research
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doi:10.1177/00220345880670060901
更新日期:1988-06-01 00:00:00
abstract::The effect of low-level laser treatment on maxillary arch dimensions after palatal surgery was investigated in Beagle dogs at an age of 12 weeks. A total of 30 dogs was used, and they were assigned to either a control group (Group C, n = 6) or one of two experimental groups (Group L, n = 12; and group LL, n = 12). Aft...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700111501
更新日期:1991-11-01 00:00:00
abstract::Although pulp fibroblasts are a major cell type in dental pulp, their roles in microbial recognition and pulpal inflammation are not well-understood. Considering the pivotal role of Toll-like receptors (TLRs) in the recognition of micro-organisms, we hypothesized that TLRs on pulp fibroblasts may induce inflammatory s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509354720
更新日期:2010-02-01 00:00:00
abstract::Morphogenesis (germ-tube formation) in Candida albicans was induced gratuitously by N-acetylhexosamine derivatives (N-acetyl-glucosamine covalently linked to agarose, N-acetylmannosamine, hyaluronic acid, colloidal chitin, and mucin). These compounds were not taken up by the yeast cells and did not support growth. 2-D...
journal_title:Journal of dental research
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abstract::Tooth loss is a significant health issue currently affecting millions of people worldwide. Artificial dental implants, the current gold standard tooth replacement therapy, do not exhibit many properties of natural teeth and can be associated with complications leading to implant failure. Here we propose bioengineered ...
journal_title:Journal of dental research
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abstract::Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750090901
更新日期:1996-09-01 00:00:00
abstract::The object of the present study was an attempt to relate fluoride concentration in enamel, caries experience, and the degree of fluorosis in a community residing in an area with a high level of fluoride. A significant difference was found between the male and female samples for the F and D parameters. A positive corre...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550012001
更新日期:1976-01-01 00:00:00
abstract::Antimicrobial agents, delivered either by mouthrinse or toothpaste, can be used to maintain plaque at levels compatible with oral health by (a) reducing existing plaque, (b) preventing the formation of new plaque, (c) selectively inhibiting those particular bacteria that are associated with disease, and (d) inhibiting...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
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更新日期:1992-07-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600100501
更新日期:1981-10-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650031401
更新日期:1986-03-01 00:00:00
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更新日期:1993-01-01 00:00:00
abstract::While dental pulp appears to be able to form mineralized matrices that do not always resemble dentin, the precise characteristics of the hard tissue and the mechanism of its induction remain unknown. Therefore, we evaluated hard tissue induced by transplantation of pulp into subcutaneous tissue. Seven days after trans...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600515
更新日期:2007-05-01 00:00:00
abstract::Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660s108
更新日期:1987-02-01 00:00:00
abstract::Previous research, in which the bonding effectiveness of the 3 self-etch monomers HAEPA, EAEPA, and MAEPA was determined, showed that MAEPA was most effective. In this study, the molecular interactions of these monomers with hydroxyapatite and dentin were investigated by combining x-ray diffraction, infrared spectrosc...
journal_title:Journal of dental research
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doi:10.1177/0022034510397197
更新日期:2011-05-01 00:00:00
abstract::Our observations confirm the previously reported observation that multinucleated cells develop within a two-week period in cat bone-marrow cultures. Calcitonin induces cytoplasmic contraction in these multinucleated cells, which indicates that they resemble osteoclasts. After seven days of culture, cat bone-marrow cul...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650070201
更新日期:1986-07-01 00:00:00
abstract::Cell therapies utilizing mesenchymal stem cells (MSCs) could overcome limitations of traditional treatments for reconstructing craniofacial tissues. This large-scale study explored a standardized methodology for the isolation and clinical-scale expansion of alveolar bone marrow-derived MSCs (aBMSCs). We harvested 103 ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513510530
更新日期:2014-01-01 00:00:00
abstract::Dental plaque collected from the label aspect of the anterior dentition of children harbored Neisseria that synthesized an extracellular iodophilic polysaccharide (EIP) from sucrose. Gas chromatograms of fully-acetylated EIP derivatives indicated that glucose (97%) and galactose (3%) were the only monosaccharide const...
journal_title:Journal of dental research
pub_type: 杂志文章
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更新日期:1982-05-01 00:00:00
abstract::A previously reported technique for staining areas of degradation in dental composite restorations was evaluated in 51 removed restorations. The staining reagent was silver nitrate, which penetrated the degraded subsurface as ionic silver and was subsequently developed into colored deposits of metallic silver. Several...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700031201
更新日期:1991-03-01 00:00:00
abstract::Once established, early-colonizing bacterial species tend to persist in the mouth. To obtain detailed information on the population dynamics of early-colonizing oral anaerobes, we examined the clonal diversity and persistence of clones among oral Fusobacterium nucleatum populations during the first 2 yrs of life. Cons...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300613
更新日期:2004-06-01 00:00:00