Distribution and excretion of TEGDMA in guinea pigs and mice.

Abstract:

:The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-TEGDMA applied via gastric, intradermal, and intravenous administration at dose levels well above those encountered in dental care were examined in vivo in guinea pigs and mice as a test of the hypothesis that TEGDMA reaches cytotoxic levels in mammalian tissues. 14C-TEGDMA was taken up rapidly from the stomach and small intestine after gastric administration in both species and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as 14CO2. The peak equivalent TEGDMA levels in all mouse and guinea pig tissues examined were at least 1000-fold less than known toxic levels. The study therefore did not support the hypothesis.

journal_name

J Dent Res

authors

Reichl FX,Durner J,Hickel R,Kunzelmann KH,Jewett A,Wang MY,Spahl W,Kreppel H,Moes GW,Kehe K,Walther U,Forth W,Hume WR

doi

10.1177/00220345010800050501

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

1412-5

issue

5

eissn

0022-0345

issn

1544-0591

journal_volume

80

pub_type

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