Abstract:
:Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechanical sensitivity of the whisker pad skin following IANX, neuronal nitric oxide synthase (nNOS) expression in the trigeminal ganglion (TG), and the functional significance of NO in relation to the mechanical allodynia following intra-TG administration of a chemical precursor to NO and selective nNOS inhibitors. IANX induced mechanical allodynia, which was diminished by intra-TG administration of selective nNOS inhibitors. NO metabolites and nNOS immunoreactive neurons innervating the lower lip were also increased in the TG. Intra-TG administration of nNOS substrate induced the mechanical allodynia. The present findings suggest that NO released from TG neurons regulates the excitability of TG neurons innervating the whisker pad skin, and the enhancement of TG neuronal excitability may underlie ectopic mechanical allodynia.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Sugiyama T,Shinoda M,Watase T,Honda K,Ito R,Kaji K,Urata K,Lee J,Ohara K,Takahashi O,Echizenya S,Iwata Kdoi
10.1177/0022034513509280subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1113-7issue
12eissn
0022-0345issn
1544-0591pii
0022034513509280journal_volume
92pub_type
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