Abstract：
:Rat parotid atrophy, induced by liquid feeding over 10 days, was manifested as gland weight loss (40%) and histologically as acinar shrinkage. Acinar secretory function was investigated in the same glands using enzymatically dispersed cell preparations and superfused gland slices. Results were normalized for the acinar proportional volume, determined by stereological analysis. Although total amylase activity was significantly lower in liquid-fed (LD) rats, the percentage amylase releases elicited by isoproterenol (10 mumol/L) and carbachol (10 mumol/L) were unchanged from controls (CON). Superfused gland slices from LD and control (CON) rats exhibited increases in membrane permeability (86Rb+ efflux) and in the efflux and re-uptake of K+ in response to acetylcholine (10 mumol/L). However, the recorded maxima were significantly lower in LD than in CON (86Rb+, 27% lower; K+ efflux, 35% lower; K+ re-uptake, 35% lower). Similarly, after 60-minute equilibration, the 36Cl- content of cells from LD rats was 57% lower than that from CON. Carbachol (10 mumol/L), acting for 1 min with bumetanide (100 mumol/L), elicited an efflux of 36Cl- from cells from LD rats, but this was significantly lower (32.2%) in LD than in CON (49.9%). The reduced levels of ion movement are probably commensurate with the reduced acinar cell volume occurring in LD rats. These results show that mechanisms for the formation of primary saliva (exocytosis and transepithelial ion movements) are substantially preserved in the altered acinar cells of LD rats. Thus, in salivary disorders, severe morphological acinar atrophy may not inevitably signify exhausted secretory function.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Scott J,Gunn DLdoi
10.1177/00220345940730060901subject
Has Abstractpub_date
1994-06-01 00:00:00pages
1180-6issue
6eissn
0022-0345issn
1544-0591journal_volume
73pub_type
杂志文章abstract：:Previous studies have clearly established the down-regulating effect of a sucrose-rich diet on primary dentinogenesis in rat molars. Earlier observation of the negative effect of a high-sucrose diet on a parotid function involved in the control of intradentinal solute movement led us to hypothesize that parotid gland ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100407
更新日期：2002-04-01 00:00:00
abstract：:The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400409
更新日期：2005-04-01 00:00:00
abstract：:Although dental amalgam is used frequently under artificial crowns for restoration of severely damaged teeth, there is little information available on the bond between luting cements and this alloy. This study was designed for determination of the strength of the bond between a dental amalgam alloy and three crown-lut...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680111501
更新日期：1989-11-01 00:00:00
abstract：:Acidic proline-rich proteins were localized histologically by means of the indirect immunoperoxidase technique in the acinar cells of parotid and submandibular gland sections of both man and Macaca fascicularis. These proteins were also identified as constituents of the long term in vivo-formed acquired pellicle on hu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590081201
更新日期：1980-08-01 00:00:00
abstract：UNLABELLED:The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034510393516
更新日期：2011-05-01 00:00:00
abstract：:Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690050901
更新日期：1990-05-01 00:00:00
abstract：:Levels of mutans streptococci in plaque samples from margins of Class II amalgam (Dispersalloy), composite (P-10), and glass-ionomer (Ketac Silver) restorations were compared. Fifty-one children, each having one of the restorations in a permanent first molar, were part of an inter-individual comparison, giving 17 rest...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690030601
更新日期：1990-03-01 00:00:00
abstract：:Disks of dentin taken from extracted human teeth demonstrated the optical property of the magnification/reduction effect. When images were transmitted from a pulpal-to-occlusal direction, the images were magnified. When the disks were inverted, the images were reduced in size. The images were slightly distorted but cl...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550041601
更新日期：1976-07-01 00:00:00
abstract：:1) A new adhesive opaque resin containing a reactive monomer, 4-methacryloxy-ethyl trimellitate anhydride (4-META), was prepared, and its application to thermosetting acrylic resin veneer crowns was studied. 2) The 4-META opaque resin was applied to a variety of nickel-chromium dental alloy specimens which had undergo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600091101
更新日期：1981-09-01 00:00:00
abstract：:Much research has been devoted to the study of etched enamel, since it is critical to bonding. Currently, there are no precise data regarding the etched-enamel specific surface area. The aim of this study was to characterize, by two different methods, the surface of human dental enamel in vitro after being etched. It ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700607
更新日期：2008-06-01 00:00:00
abstract：:When one uses composite resins, the curing contraction, the stiffness of the material, and the strength of the vulnerable dentinal bond are important factors in determining the marginal adaptation of the restoration. Calculations based on these intrinsic material properties have indicated that both bulk placement and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670050901
更新日期：1988-05-01 00:00:00
abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520913873
更新日期：2020-07-01 00:00:00
abstract：:Dispersed salivary acini isolated from the rat submandibular gland by enzymatic digestion were used to study the effects of alpha-receptor stimulation on transmembrane transport of 36Cl. In the absence of secretagogue, the tracer accumulated in the cells in a time-dependent manner until a steady-state content of 6.8 +...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670030701
更新日期：1988-03-01 00:00:00
abstract：:Relative glycogen synthetic abilities of resting cells of fresh clinical isolates of Actinomyces viscosus and Actinomyces naeslundii originating from dental plaque samples over root surface caries lesions and non-carious sites were studied under anaerobic conditions at a constant pH of 7.0, with U-(14C)-glucose used a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650060701
更新日期：1986-06-01 00:00:00
abstract：:In two separate experiments, none of the 14 subunits examined consistently ranked dentifrices similarly to the ranking obtained when the individual rat was used as the experimental unit. Arbitrarily dividing the rat into subunits and then comparing results among these subunits may lead to false conclusions since the r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550032901
更新日期：1976-05-01 00:00:00
abstract：:Protease-activated receptors (PARs) are G protein-coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 and PAR-2 gene expres...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517719415
更新日期：2017-12-01 00:00:00
abstract：:Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660s108
更新日期：1987-02-01 00:00:00
abstract：:Diabetes mellitus is associated with depression of natural defenses against infection and increases the risk of periodontal disease. However, the effects of diabetes on periradicular tissue, which differs structurally from periodontal tissue, are not known. In this study, we evaluated the effects of type 2 diabetes on...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200416
更新日期：2003-04-01 00:00:00
abstract：:Dental diseases are now viewed as a consequence of a deleterious shift in the balance of the normally stable resident oral microbiome. It is known that frequent carbohydrate consumption or reduced saliva flow can lead to caries, and excessive plaque accumulation increases the risk of periodontal diseases. However, whe...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517742139
更新日期：2018-04-01 00:00:00
abstract：:Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Hum...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509357172
更新日期：2010-03-01 00:00:00
abstract：:In 1992 and 1997, all US and Canadian dental schools were surveyed by mail regarding the preferred initial radiographic examination prescribed for non-emergency, comprehensive-care patients (dentulous adults, edentulous adults, and children). In both survey years, a minority of US and Canadian dental schools reported ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790071701
更新日期：2000-07-01 00:00:00
abstract：:The effects of thermal stress on the marginal leakage of resin composite restorations in bovine teeth were investigated by a method that preserved the specimens. The changes in marginal leakage of specimens with increasing numbers of thermal cycles were measured by an electrical conductivity method. Four brands of pos...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690100601
更新日期：1990-10-01 00:00:00
abstract：:Caries of the permanent first molars of 5-year-old children was found to be associated with caries of their diciduous teeth. The sample consisted of 220 children whose permanent first molars had erupted. They were selected out of 965 children who were a representative sample of children attending compulsory kindergart...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550062001
更新日期：1976-11-01 00:00:00
abstract：:Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the caries process. To determine whether they differ in their responses to oral pathogens, we performed a systematic comparative analysis o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700304
更新日期：2008-03-01 00:00:00
abstract：:Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment. Prostaglandin E1 or E2 solutions injected in gingiva lying near the upper first molar caused the appearance of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590101301
更新日期：1980-10-01 00:00:00
abstract：:Previous studies have suggested that information provided by periodontal mechanoreceptors is particularly important for the fine motor control of the mandible, i.e., when humans hold and carefully manipulate food particles between the teeth with low biting forces. In the present study, we further evaluated this hypoth...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770041001
更新日期：1998-04-01 00:00:00
abstract：:A quantitative microprobe analysis was conducted on three commercial amalgams to determine the nature of the phases present. The presence of tin in the Ag-Hg phase (gamma1) was confirmed and Cu-3Sn was found in the original alloy particles. In the dispersant amalgam studied, little Sn-Hg phase (gamma-2) was found and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:Cross-sectional areas of the masseter, temporalis and medial, and lateral pterygoid muscles were determined in 16 subjects by means of computer tomography. In each subject three scans were made, intersecting the thickest part of the muscles at right angles to the fiber direction. The masseter and medial pterygoid musc...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630091201
更新日期：1984-09-01 00:00:00
abstract：:It is shown that the creep behavior of a commercial dispersant-amalgam containing copper is improved by the addition of a manganese-containing alloy. This improvement is apparently obtained without any serious changes in corrosion resistance, provided that no more than 20% of the Mn alloy is added. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570090601
更新日期：1978-09-01 00:00:00
abstract：:In this study, we investigated whether selective activation of nociceptive primary afferent fibers by capsaicin would induce modulations on tooth-pulp-evoked sensory or inhibitory masseter reflex responses in healthy human subjects. The contribution of central N-methyl-D-aspartate (NMDA) receptor mechanisms in capsaic...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760090801
更新日期：1997-09-01 00:00:00
