Abstract：
:Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic development. However, its role in post-natal dentinogenesis is largely unknown. To address this issue, we studied the role of DKK1 in post-natal dentin development using 2.3-kb Col1a1-Dkk1 transgenic mice, with the following key findings: (1) The Dkk1 transgene was highly expressed in pulp and odontoblast cells during post-natal developmental stages; (2) the 1(st) molar displayed short roots, an enlarged pulp/root canal region, and a decrease in the dentin formation rate; (3) a small malformed second molar and an absent third molar; (4) an increase of immature odontoblasts, few mature odontoblasts, and sharply reduced dentinal tubules; and (5) a dramatic change in Osx and nestin expression. We propose that DKK1 controls post-natal mandibular molar dentin formation either directly or indirectly via the inhibition of Wnt signaling at the following aspects: (i) post-natal dentin formation, (ii) formation and/or maintenance of the dentin tubular system, (iii) mineralization of the dentin, and (iv) regulation of molecules such as Osx and nestin.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Han XL,Liu M,Voisey A,Ren YS,Kurimoto P,Gao T,Tefera L,Dechow P,Ke HZ,Feng JQdoi
10.1177/0022034511421926subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1312-7issue
11eissn
0022-0345issn
1544-0591pii
0022034511421926journal_volume
90pub_type
杂志文章abstract：:The incorporation of polymerizable cationic monomers has been attempted to generate dental resinous materials with antibacterial activity. This study tested the hypothesis that a dental adhesive containing a cationic monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), would influence biofilm format...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509334499
更新日期：2009-04-01 00:00:00
abstract：:Two series of dental composites, along with the unfilled resin matrix, were examined to determine the effects of filler level and size on selected properties. Both series were prepared by incorporating a silanated barium borosilicate filler into a visible-light-activated polyphenylene polymethacrylate resin matrix. On...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121501
更新日期：1985-12-01 00:00:00
abstract：:In the current theme of dental pulp regeneration, biological and synthetic scaffolds are becoming a potential therapy for pulp revitalization. The goal is to provide a suitable environment for cellular infiltration, proliferation, and differentiation. The extracellular matrix (ECM) represents a natural scaffold materi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518785124
更新日期：2018-12-01 00:00:00
abstract：:Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent incre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301111
更新日期：2004-11-01 00:00:00
abstract：:Previous studies have shown that extracts of various filling materials, e.g., resin composites, may influence the growth of cariogenic micro-organisms. The purpose of this study was to examine the effects of important resin composite (co)monomers (Bis-GMA, UDMA, TEGDMA, EGDMA) and extracts of two commercial dental com...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770010601
更新日期：1998-01-01 00:00:00
abstract：:Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Moderate elevation of serum C-reactive protein (CRP) is a risk factor for cardiovascular disease among apparently healthy individuals, although factors that create this inflammatory response in the absence of systemic illness have not been clarified. This study aimed to: (1) evaluate associations among periodontal dis...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790010701
更新日期：2000-01-01 00:00:00
abstract：:Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513516979
更新日期：2014-03-01 00:00:00
abstract：:Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600818
更新日期：2007-08-01 00:00:00
abstract：:Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690050901
更新日期：1990-05-01 00:00:00
abstract：:microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516657043
更新日期：2016-11-01 00:00:00
abstract：:Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518772260
更新日期：2018-09-01 00:00:00
abstract：:The sensitizing potential of three periodontal dressing materials was evaluated by the guinea pig maximization test. The results indicated a difference in the sensitization rate of the three materials. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570110801
更新日期：1978-11-01 00:00:00
abstract：:This study demonstrated that human submandibular-sublingual saliva (HSMSL) provided a better substrate than did whole saliva or parotid saliva for the binding of Streptococcus sanguis in a glass adherence assay. Additional evidence indicated that the lower molecular weight salivary mucin in HSMSL was involved in these...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610120101
更新日期：1982-12-01 00:00:00
abstract：:The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515593055
更新日期：2015-10-01 00:00:00
abstract：:Periodontal data typically consist of observations made at multiple sites within each patient. Observations within a patient tend to be positively correlated; hence, standard statistical techniques that assume independence are invalid. Regression techniques for correlated data have been proposed; communicating results...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200705
更新日期：2003-07-01 00:00:00
abstract：:In vitro wear data were determined for nine experimental composites and compared with two-year clinical data. The in vitro tests included single-pass wear and two-body abrasion. The in vivo data were obtained between 1978 and 1980 for 54 class 2 posterior composite restorations in 25 patients. Correlations between the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620101801
更新日期：1983-10-01 00:00:00
abstract：:The antimicrobial and cariostatic activities of the dihydrochloride and dihydrofluoride salts of alexidine (1,6-bis-[2-ethylhexylbiguanido]hexane) were compared to those of chlorhexidine acetate and sodium fluoride in rats implanted orally with Streptococcus mutans 6715 and fed a cariogenic diet. Experimental caries w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580041901
更新日期：1979-04-01 00:00:00
abstract：:Mutans streptococci (MS) are generally considered to be the principal etiological agent of dental caries. MS have two important virulence factors: cell- surface protein PAc and glucosyltransferases (GTFs). GTFs have two functional domains: an N-terminal catalytic sucrose-binding domain (CAT) and a C-terminal glucan-bi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509336727
更新日期：2009-05-01 00:00:00
abstract：:Stem cells are remarkable, and stem cell-based tissue engineering is an emerging field of biomedical science aiming to restore damaged tissue or organs. In dentistry and reconstructive facial surgery, it is of great interest to restore lost teeth or craniofacial bone defects using stem cell-mediated therapy. In the cr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515603972
更新日期：2015-11-01 00:00:00
abstract：:Ten dental casting alloys were tested for alloy-element release into cell-culture medium, and this release was related to alloy composition, alloy microstructure, and alloy cytotoxicity (previously determined). Cell-culture medium was analyzed for alloy elements by flame atomic absorption. Concentrations of elements i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700060301
更新日期：1991-06-01 00:00:00
abstract：:Ten cats were immunized with subcutaneous injections of keyhole limpet hemocyanin (KLH). After it was determined that the experimental animals had developed circulating antibodies to KLH, challenge doses of KLH were administered via the root canal system. The radiographic and histologic findings suggest that antigen-a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590011601
更新日期：1980-01-01 00:00:00
abstract：:The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available ...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析
doi：10.1177/0022034518800014
更新日期：2019-01-01 00:00:00
abstract：:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit bud-stage developmental arrest of the mandibular molar t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517713710
更新日期：2017-09-01 00:00:00
abstract：:Tempering of dental porcelain by forced convective cooling in air has been shown previously to inhibit the sizes of cracks induced in porcelain surfaces. However, the depth of compressive stress that is produced by tempering of feldspathic porcelain has not been determined. It can be assumed that the potential of temp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700020701
更新日期：1991-02-01 00:00:00
abstract：:Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590071001
更新日期：1980-07-01 00:00:00
abstract：:Although dental amalgam is used frequently under artificial crowns for restoration of severely damaged teeth, there is little information available on the bond between luting cements and this alloy. This study was designed for determination of the strength of the bond between a dental amalgam alloy and three crown-lut...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680111501
更新日期：1989-11-01 00:00:00
abstract：:Conservative techniques for improving the appearance of discolored teeth have become popular in the past decade. These include: in-office bleaching with 30% hydrogen peroxide, which is applied on etched enamel with a gauze pad and then exposed to a bleaching light; home bleaching with a mild form of peroxide, such as ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720011001
更新日期：1993-01-01 00:00:00
abstract：:Joining a brittle veneer to a strong ceramic core with an adhesive offers potential benefits over current fabrication methods for all-ceramic crowns. We tested the hypothesis that such joining can withstand subsurface radial cracking in the veneer, from enhanced flexure in occlusal loading, as well as in the core. Cri...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700408
更新日期：2008-04-01 00:00:00
abstract：:The pellicle serves as a multifunctional protective layer, providing, e.g., lubrication and remineralization and also acting as a diffusion barrier. In addition, since the formation of the pellicle precedes the adhesion of micro-organisms, it is also important as a conditioning film. We present a novel approach to stu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512456704
更新日期：2012-10-01 00:00:00
