Chondroitin sulfate in palatal wound healing.

Abstract:

:Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent increase in cell adhesion and cell proliferation, whereas the reverse effects were seen after chondroitinase degradation of chondroitin sulfate. The biological actions of chondroitin sulfate appeared to be dependent on the presence and position of sulfate groups. Inhibition of glycosaminoglycan sulfation by chlorate treatment led to reduced cell adhesion and cell proliferation and a slower rate of wound closure in vitro. Furthermore, exposure to chondroitin-4-sulfate resulted in a dose-dependent reduction in cell adhesion. Together, these results show that chondroitin sulfate is involved in palatal wound healing.

journal_name

J Dent Res

authors

Zou XH,Foong WC,Cao T,Bay BH,Ouyang HW,Yip GW

doi

10.1177/154405910408301111

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

880-5

issue

11

eissn

0022-0345

issn

1544-0591

pii

83/11/880

journal_volume

83

pub_type

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