Role of TNF-alpha and its receptors in pericoronitis.

abstract：:Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...

journal_title：Journal of dental research

authors： Roberts MC,Leroux BG,Sampson J,Luis HS,Bernardo M,Leitão J

更新日期：2008-05-01 00:00:00

abstract：:Pain and discomfort are common problems for patients undergoing orthodontic treatment. We have demonstrated that cortical excitation propagation in the somatosensory and insular cortices (IC) induced by electrical stimulation of the periodontal ligament (PDL) is facilitated 1 d after experimental tooth movement (ETM)....

journal_title：Journal of dental research

authors： Horinuki E,O'Hashi K,Kobayashi M

更新日期：2020-10-08 00:00:00

abstract：:During periods of periodontal attachment loss, one of the most significant cellular changes is a decrease in the number of fibroblasts. We previously demonstrated that LPS induces apoptosis of fibroblastic cells in vivo, largely through TNF-alpha. We conducted in vivo experiments by subcutaneous inoculation of LPS in ...

journal_title：Journal of dental research

authors： Alikhani M,Alikhani Z,Graves DT

更新日期：2004-09-01 00:00:00

abstract：:The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...

journal_title：Journal of dental research

authors： Gao XJ,Elliott JC,Anderson P

更新日期：1993-05-01 00:00:00

abstract：:Amylase activity in various tissues--i.e., submandibular/sublingual and parotid glands, the pancreas, saliva, and serum--in rats was measured after injection of isoproterenol, pilocarpine, and acetylcholine. All agents reduced amylase activity in the parotid gland and increased the enzyme activity in the submandibular...

journal_title：Journal of dental research

authors： Ikeno T,Nasu J,Kuzuya H

更新日期：1983-01-01 00:00:00

abstract：:Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without...

journal_title：Journal of dental research

authors： McKee MD,Yadav MC,Foster BL,Somerman MJ,Farquharson C,Millán JL

更新日期：2013-08-01 00:00:00

abstract：:Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...

journal_title：Journal of dental research

authors： Sugiyama T,Shinoda M,Watase T,Honda K,Ito R,Kaji K,Urata K,Lee J,Ohara K,Takahashi O,Echizenya S,Iwata K

更新日期：2013-12-01 00:00:00

abstract：:Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...

journal_title：Journal of dental research

authors： Yamakoshi Y,Kinoshita S,Izuhara L,Karakida T,Fukae M,Oida S

更新日期：2014-07-01 00:00:00

abstract：:We previously demonstrated that an anti-caries DNA vaccine intranasally administered with recombinant flagellin protein as a mucosal adjuvant enhanced salivary IgA response and conferred better protection against caries. However, the relatively weak immunogenicity of DNA vaccines and the necessity for a large quantity...

journal_title：Journal of dental research

authors： Sun Y,Shi W,Yang JY,Zhou DH,Chen YQ,Zhang Y,Yang Y,He BX,Zhong MH,Li YM,Cao Y,Xiao Y,Li W,Yu J,Li YH,Fan MW,Yan HM

更新日期：2012-10-01 00:00:00

abstract：:Chemical bonding between dental porcelains and alloys results from interdiffusion of porcelain and metal ions. An interfacial diffusion zone is created which, most likely, has properties different from those of bulk materials. The changed interface might affect experimental measurements of thermo-mechanical strain. To...

journal_title：Journal of dental research

authors： Tesk JA,Hinman RW,Widera GE,Holmes AD,Cassel JM

更新日期：1983-05-01 00:00:00

abstract：:A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a re...

journal_title：Journal of dental research

authors： Pashley DH,Livingston MJ,Outhwaite WC

更新日期：1977-01-01 00:00:00

abstract：:A series of 4,6-dichloro-1,3,5-triazines [e.g., 2-allylamino-(ADT), diallylamino-(DADT), 2-N-p-allyloxyphenylamino-, 2-N-allyl-N-phenylamino-, and 2-N-allyl-N-p-tolylamino-4,6-dichloro-1,3,5-triazine] was synthesized and characterized by IR, NMR, and mass spectrometry. These monomers have chlorine atoms that can react...

journal_title：Journal of dental research

authors： Lee CH,Liu XQ,Gong XQ

更新日期：1986-12-01 00:00:00

abstract：:Estrogen deficiency results in disruption of maxillary alveolar bone microarchitecture. Most of the actions of estrogen in long bones occur via estrogen receptor α (ERα). However, the function of ERα in the maxillary bone has not been defined. We aimed to investigate the role and underlying mechanisms of ERα in the ph...

journal_title：Journal of dental research

authors： Macari S,Ajay Sharma L,Wyatt A,Knowles P,Szawka RE,Garlet GP,Grattan DR,Dias GJ,Silva TA

更新日期：2016-06-01 00:00:00

abstract：:A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...

journal_title：Journal of dental research

authors： Wang L,Tran AB,Nociti FH Jr,Thumbigere-Math V,Foster BL,Krieger CC,Kantovitz KR,Novince CM,Koh AJ,McCauley LK,Somerman MJ

更新日期：2015-10-01 00:00:00

abstract：:Purinergic signaling is involved in pain generation and modulation in the nociceptive sensory nervous system. Adenosine triphosphate (ATP) induces pain via activation of ionotropic P2X receptors while adenosine mediates analgesia via activation of metabotropic P1 receptors. These purinergic signaling are determined by...

journal_title：Journal of dental research

authors： Liu X,Ma L,Zhang S,Ren Y,Dirksen RT

更新日期：2017-06-01 00:00:00

abstract：:The dental phenolic medicaments, eugenol and guaiacol, are partly similar in chemical structure to capsaicin, the pungent constituent of chili peppers, which selectively activates sensory neurons via a specific receptor. We have previously demonstrated that these phenolic compounds show capsaicin-like action. In the p...

journal_title：Journal of dental research

authors： Ohkubo T,Shibata M

更新日期：1997-04-01 00:00:00

abstract：:Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...

journal_title：Journal of dental research

authors： Kim JW,Kim JH,Janal MN,Zhang Y

更新日期：2008-12-01 00:00:00

abstract：:Hemifacial microsomia (HFM) is a congenital disorder marked by facial asymmetry. Whether facial asymmetry accounts for asymmetrical dental development is unknown. There are few data on dental development relative to mandibular development or severity of HFM, or on development over time. We hypothesized that when mandi...

journal_title：Journal of dental research

authors： Ongkosuwito EM,de Gijt P,Wattel E,Carels CE,Kuijpers-Jagtman AM

更新日期：2010-12-01 00:00:00

abstract：:Stable fluoride-resistant mutants of Streptococcus mutans GS-5 were isolated on Todd-Hewitt agar by a step-wise selection procedure. Resistance is defined here as the ability to form colonies in 48 hr. First-step mutants demonstrated six different levels of resistance, ranging from 400 to 1000 micrograms/mL sodium flu...

journal_title：Journal of dental research

authors： Brussock SM,Kral TA

更新日期：1987-10-01 00:00:00

abstract：:The relationship between occlusal stimuli and a hypofunctional periodontal ligament (PDL) structure has been reported, though changes in occlusal recovery conditions were still unclear. Nitric oxide (NO) produced by NO synthase (NOS) is considered a factor for vascular and immune system control, and it increases accor...

journal_title：Journal of dental research

authors： Watarai H,Warita H,Soma K

更新日期：2004-04-01 00:00:00

abstract：:Teeth develop through distinct morphological stages. At the cap stage, a compactly clustered and concentrically arranged cell mass, the enamel knot, appears at the tip of the enamel organ. Cells in this knot express sets of key molecules, and as such have been proposed to act as a signaling center directing tooth morp...

journal_title：Journal of dental research

authors： Liu M,Zhao S,Wang XP

更新日期：2014-05-01 00:00:00

abstract：:Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...

journal_title：Journal of dental research

authors： Kirkham J,Robinson C,Strafford SM,Shore RC,Bonass WA,Brookes SJ,Wright JT

更新日期：1996-09-01 00:00:00

abstract：:The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins. Much like its more famous sibling, the biological role of p63 is quite complex, with wide-ranging effects on development, differentiation, and cellular lineage choices. The crucial function of p63 is ep...

journal_title：Journal of dental research

authors： Romano RA,Solomon LW,Sinha S

更新日期：2012-02-01 00:00:00

abstract：:Dental diseases are now viewed as a consequence of a deleterious shift in the balance of the normally stable resident oral microbiome. It is known that frequent carbohydrate consumption or reduced saliva flow can lead to caries, and excessive plaque accumulation increases the risk of periodontal diseases. However, whe...

journal_title：Journal of dental research

authors： Rosier BT,Marsh PD,Mira A

更新日期：2018-04-01 00:00:00

abstract：:Evidence that dental status affects diet is equivocal. The hypothesis of this study was that diet was affected by dental status. The objective was to assess the relationship between numbers of teeth and diet and nutritional status in US adult civilians without prostheses. We examined 6985 NHANES (1988-1994) participan...

journal_title：Journal of dental research

authors： Nowjack-Raymer RE,Sheiham A

更新日期：2007-12-01 00:00:00

abstract：:Minimally invasive caries-removal procedures remove only caries-infected dentin and preserve caries-affected dentin that becomes remineralized. Dental cements containing calcium phosphate promote remineralization. This study evaluated the in vivo remineralization capacity of resin-based calcium-phosphate cement (Ca-P)...

journal_title：Journal of dental research

authors： Peters MC,Bresciani E,Barata TJ,Fagundes TC,Navarro RL,Navarro MF,Dickens SH

更新日期：2010-03-01 00:00:00

abstract：:This case-control study evaluated the association of headache and other co-morbid pain with temporomandibular disorder (TMD) pain in adolescents and explored the temporal co-variance of headache and TMD pain. In a population-based sample of 12- to 19-year-olds, 350 patients with self-reported TMD pain and 350 healthy ...

journal_title：Journal of dental research

authors： Nilsson IM,List T,Drangsholt M

更新日期：2013-09-01 00:00:00

abstract：:A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...

journal_title：Journal of dental research

authors： Wang L,Foster BL,Kram V,Nociti FH Jr,Zerfas PM,Tran AB,Young MF,Somerman MJ

更新日期：2014-08-01 00:00:00

abstract：:Dimensions and velocity of mandibular movement are important variables in the evaluation of masticatory and speech patterns. However, little information is available concerning elderly dentates and their oral motor function and behavior. Double recordings of a chewing period, from start to swallowing, were performed i...

journal_title：Journal of dental research

authors： Karlsson S,Carlsson GE

更新日期：1990-02-01 00:00:00

abstract：:Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...

journal_title：Journal of dental research

authors： Chan HC,Mai L,Oikonomopoulou A,Chan HL,Richardson AS,Wang SK,Simmer JP,Hu JC

更新日期：2010-07-01 00:00:00