Abstract：
:During periods of periodontal attachment loss, one of the most significant cellular changes is a decrease in the number of fibroblasts. We previously demonstrated that LPS induces apoptosis of fibroblastic cells in vivo, largely through TNF-alpha. We conducted in vivo experiments by subcutaneous inoculation of LPS in wild-type, TNFR1-/-R2-/-, TNFR1-/-, and TNFR2-/- mice to identify which TNF receptors are involved and the specific caspase pathway activated. LPS stimulated apoptosis through TNFR1 but not TNFR2, which was accompanied by the induced expression of 12 apoptotic genes. Fluorometric studies demonstrated that LPS in vivo significantly increased caspase-8 and caspase-3 activity, which was also dependent on TNF receptor signaling. By the use of specific caspase inhibitors, caspases-3 and -8 were shown to play an important role in LPS-induced apoptosis in vivo. Thus, LPS acts through TNFR1 to modulate the expression of apoptotic genes and activate caspases-3 and -8.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Alikhani M,Alikhani Z,Graves DTdoi
10.1177/154405910408300903keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
671-6issue
9eissn
0022-0345issn
1544-0591pii
83/9/671journal_volume
83pub_type
杂志文章abstract：:Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200505
更新日期：2003-05-01 00:00:00
abstract：:Strength and durability of the dentin-acrylic resin joint cemented with 2-cyanoacrylate esters were studied. Maximum adhesion is obtained with isobutyl 2-cyanoacrylate after 1% acid pretreatment of the dentin. Hydrolytic stability is somewhat improved by addition of polymer to the adhesive or coating around the joint....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580090901
更新日期：1979-09-01 00:00:00
abstract：:Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510376543
更新日期：2010-11-01 00:00:00
abstract：:The ability of physiological amounts of lysozyme to de-chain two serotype c strains of Streptococcus mutans was determined. Both human and hen lysozymes were equally effective in chain breakage of S. mutans DPR and S. mutans DJR. De-chaining did not affect growth of cultures, but resulted in finely dispersed suspensio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640010901
更新日期：1985-01-01 00:00:00
abstract：:Numerous studies have demonstrated that many older adults have problems chewing, pain, difficulties in eating, and problems in social relationships because of oral disorders. However, it is not clear if these functional and psychosocial outcomes affect broader psychological well-being and life satisfaction. Consequent...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790041301
更新日期：2000-04-01 00:00:00
abstract：:The effect of low-level laser treatment on maxillary arch dimensions after palatal surgery was investigated in Beagle dogs at an age of 12 weeks. A total of 30 dogs was used, and they were assigned to either a control group (Group C, n = 6) or one of two experimental groups (Group L, n = 12; and group LL, n = 12). Aft...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700111501
更新日期：1991-11-01 00:00:00
abstract：:The relationship between occlusal stimuli and a hypofunctional periodontal ligament (PDL) structure has been reported, though changes in occlusal recovery conditions were still unclear. Nitric oxide (NO) produced by NO synthase (NOS) is considered a factor for vascular and immune system control, and it increases accor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300413
更新日期：2004-04-01 00:00:00
abstract：:Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse mo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519885088
更新日期：2020-01-01 00:00:00
abstract：:Pure gutta-percha was heat-treated in a differential thermal analyzer. The high melting form crystallized on cooling when gutta-percha was heated to 70 C or less. Above 74 C, crystallization into the low melting form predominated. Either polymorph can be selectively crystallized by control of the heat-treatment temper...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560120301
更新日期：1977-12-01 00:00:00
abstract：:Although the tripeptides Glu-O-Phosphoserine-Tyr and Glu-O-Phosphoserine-Leu have been identified in embryonic bovine enamel proteins, 1, 2 the issue of whether both sequences occur in each of the phosphopeptides, or whether certain sequences occur in specific peptides only, has recently been resolved by isolating hom...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580023101
更新日期：1979-03-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema. Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressure, and contribute to pain and irreversible tissue damage. Lipoteichoic acid (LTA) is an amphiphilic molecule f...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200612
更新日期：2003-06-01 00:00:00
abstract：:Mastication as a mild but life-long exercise has been examined as a possibility for maintaining brain function in the elderly. Little is known, however, about the cerebral circulatory response during masticatory movement. The aim of this study was to develop a monitoring system for circulation dynamics during masticat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510383692
更新日期：2011-01-01 00:00:00
abstract：:Thermal diffusivity, a property related to the thermal insulative efficiency of a material, was measured in nine glass-ionomer cements and compared with results from a silicate and a polycarboxylate cement. Each cement was mixed at various powder-liquid ratios (P/L) and moulded into a rectangular prism of approximate ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660051001
更新日期：1987-05-01 00:00:00
abstract：:We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512454298
更新日期：2012-09-01 00:00:00
abstract：:Although certain bacterial species appear to be risk factors for pain due to odontogenic infections, comparatively little is known about the potential mechanisms mediating this effect. In this study, we tested the hypothesis that trigeminal nociceptive neurons express the TLR4 or CD14 receptors, thus enabling sensory ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500108
更新日期：2006-01-01 00:00:00
abstract：:Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tiss...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034508330861
更新日期：2009-03-01 00:00:00
abstract：:We have investigated the role of the activation of nuclear poly(ADP-ribose) polymerase (PARP) enzyme, a mediator of downstream nitric oxide toxicity, using a combined approach of pharmacological inhibition and genetic disruption in a ligature-induced-periodontitis model in rats and mice. Immunohistochemical analysis r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308201210
更新日期：2003-12-01 00:00:00
abstract：:In an attempt to determine the degree of co-activation present in selected cervical muscles during clenching, we instructed 12 male subjects to produce four brief maximum voluntary contraction (MVC) efforts (clenching) in a position of maximum intercuspation. Surface EMG activity was recorded bilaterally from the mass...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720110701
更新日期：1993-11-01 00:00:00
abstract：:Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034514529150
更新日期：2014-07-01 00:00:00
abstract：:Resin luting of all-ceramic restorations results in increased performance; however, the strengthening mechanism and the role of the mechanical properties of the resin are not fully understood. The hypothesis tested is that ceramic strength enhancement is dependent on the elastic modulus of the resin. Three-point flexu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600606
更新日期：2007-06-01 00:00:00
abstract：:Dynamic changes of pulpal blood flow (PBF) and gingival blood flow (GBF) induced by intra-venous injection of two kinds of vasoactive drugs were observed in dogs by means of Laser Doppler Velocimetry. Intra-venous injection of norepinephrine caused PBF to increase, corresponding to the blood pressure (BP) increase, wh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680050701
更新日期：1989-05-01 00:00:00
abstract：:The effects of demineralized dentin and bone matrix on dental ectomesenchymal cells were evaluated after observation periods of two or three weeks. Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implante...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690011301
更新日期：1990-01-01 00:00:00
abstract：:Resolvins are potent anti-inflammatory mediators derived from ω-3 fatty acids. Results from our previous studies indicated that resolvin D1 (RvD1) blocks pro-inflammatory responses in salivary glands. Furthermore, RvD1 enhances salivary epithelial integrity, demonstrating its potential use for the restoration of saliv...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513519108
更新日期：2014-03-01 00:00:00
abstract：:Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). T...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400609
更新日期：2005-06-01 00:00:00
abstract：:Resin-bonded bridges may replace missing teeth and act as splints in periodontal treatment. The objective of this study was to investigate the etch pattern after electrolytic etching of selected Co-Cr alloys in hydrochloric acid and to assess the changes in alloy composition after different etching times. The alloys i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660091301
更新日期：1987-09-01 00:00:00
abstract：:The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570010901
更新日期：1978-01-01 00:00:00
abstract：:Dispersed salivary acini isolated from the rat submandibular gland by enzymatic digestion were used to study the effects of alpha-receptor stimulation on transmembrane transport of 36Cl. In the absence of secretagogue, the tracer accumulated in the cells in a time-dependent manner until a steady-state content of 6.8 +...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670030701
更新日期：1988-03-01 00:00:00
abstract：:Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable of withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism by which inflamed odontoblasts are protected fro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519869580
更新日期：2019-10-01 00:00:00
abstract：:Samples of a base mental alloy were cast and welded together using a conventional welding procedure. The joints were loaded and placed either in a corrosive environment or in air for varying time periods. The tensile and shear strength of the joints was unaffected by the corrosive environment, and the joints, despite ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600021101
更新日期：1981-02-01 00:00:00
abstract：:Acute or chronic inflammation comprises a highly prevalent type of orofacial pain and is mediated by the generation of endogenous agonists that activate numerous receptors expressed on terminals of trigeminal (TG) nociceptive afferent neurons. One such studied receptor is transient receptor potential vanilloid subtype...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034516653751
更新日期：2016-09-01 00:00:00
