Abstract:
:Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tissue response to orthodontic force, and therefore we investigated eNOS and iNOS expression in osteocytes during orthodontic force application. The upper rat molars were moved mesially by NiTi coil springs (10 cN, 120 hrs) in a split-mouth design. Immunohistochemical staining revealed that, in the tension area, eNOS-positive osteocytes increased from 24 hrs on, while iNOS-positive osteocytes remained largely constant. In the compression area, iNOS-positive osteocytes increased after 6 hrs, while eNOS- positive osteocytes increased after 24 hrs. This suggests that eNOS mediates bone formation in the tension area, while iNOS mediates inflammation-induced bone resorption in the compression area. Both eNOS and iNOS seem to be important regulators of bone remodeling during orthodontic force application.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Tan SD,Xie R,Klein-Nulend J,van Rheden RE,Bronckers AL,Kuijpers-Jagtman AM,Von den Hoff JW,Maltha JCdoi
10.1177/0022034508330861subject
Has Abstractpub_date
2009-03-01 00:00:00pages
255-60issue
3eissn
0022-0345issn
1544-0591pii
0022034508330861journal_volume
88pub_type
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