Orthodontic force stimulates eNOS and iNOS in rat osteocytes.

Abstract:

:Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tissue response to orthodontic force, and therefore we investigated eNOS and iNOS expression in osteocytes during orthodontic force application. The upper rat molars were moved mesially by NiTi coil springs (10 cN, 120 hrs) in a split-mouth design. Immunohistochemical staining revealed that, in the tension area, eNOS-positive osteocytes increased from 24 hrs on, while iNOS-positive osteocytes remained largely constant. In the compression area, iNOS-positive osteocytes increased after 6 hrs, while eNOS- positive osteocytes increased after 24 hrs. This suggests that eNOS mediates bone formation in the tension area, while iNOS mediates inflammation-induced bone resorption in the compression area. Both eNOS and iNOS seem to be important regulators of bone remodeling during orthodontic force application.

journal_name

J Dent Res

authors

Tan SD,Xie R,Klein-Nulend J,van Rheden RE,Bronckers AL,Kuijpers-Jagtman AM,Von den Hoff JW,Maltha JC

doi

10.1177/0022034508330861

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

255-60

issue

3

eissn

0022-0345

issn

1544-0591

pii

0022034508330861

journal_volume

88

pub_type

杂志文章
  • Distribution of chondroitin sulfate and dermatan sulfate in normal and inflamed human gingivae.

    abstract::The effect of inflammation on the distribution of chondroitin sulfate and dermatan sulfate proteoglycans was assessed after normal and inflamed human gingivae were stained with monoclonal antibodies against these extracellular matrix macromolecules. The tissues were obtained following periodontal surgery and reacted w...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345920710090801

    authors: Bartold PM

    更新日期:1992-09-01 00:00:00

  • Synergistic roles of amelogenin and ameloblastin.

    abstract::Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034509334749

    authors: Hatakeyama J,Fukumoto S,Nakamura T,Haruyama N,Suzuki S,Hatakeyama Y,Shum L,Gibson CW,Yamada Y,Kulkarni AB

    更新日期:2009-04-01 00:00:00

  • Oral epithelial overexpression of IL-1alpha causes periodontal disease.

    abstract::Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome tha...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408301010

    authors: Dayan S,Stashenko P,Niederman R,Kupper TS

    更新日期:2004-10-01 00:00:00

  • Orthodontics with Customized versus Noncustomized Appliances: A Randomized Controlled Clinical Trial.

    abstract::This randomized controlled trial aimed to evaluate the duration and outcome quality of orthodontic treatment with a customized fixed appliance system versus a noncustomized system. Patients ( n = 180) were randomized and received orthodontic treatment with the Insignia customized orthodontic system or the Damon Q nonc...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0022034517720913

    authors: Penning EW,Peerlings RHJ,Govers JDM,Rischen RJ,Zinad K,Bronkhorst EM,Breuning KH,Kuijpers-Jagtman AM

    更新日期:2017-12-01 00:00:00

  • Masticatory muscle silent periods in patients with MPD syndrome before and after treatment.

    abstract::Masticatory muscle silent periods were compared in normal subjects and in patients with MPD syndrome before and after a variety of psychological, physiological, and pharmacological forms of therapy. All patients initially showed prolonged silent periods in one or more of the muscles. There was a direct relationship be...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600030501

    authors: Skiba TJ,Laskin DM

    更新日期:1981-03-01 00:00:00

  • Metabolism of gingival collagen in a rat.

    abstract::The remodeling of gingival tissue was measured by determining the incorporation of tritiated proline and the disappearance of tritium activity from proline and hydroxyproline for 18 days after administration of label. There was a rapid decrease in the tritium activity from gingiva which was paralleled by a decrease in...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570023101

    authors: Orlowski WA

    更新日期:1978-02-01 00:00:00

  • Effects of neutral salts in a bench-scale caries model.

    abstract::In an earlier paper on bench-scale simulation of the caries process, it was shown that the passage of ions through ion-permselective barriers could have profound effects on the composition of the solution within the "lesion" at steady state. As indicated in earlier papers, these changes are produced by unequal rates o...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650090201

    authors: Brown WE,Chow LC

    更新日期:1986-09-01 00:00:00

  • Different roles of odontoblasts and fibroblasts in immunity.

    abstract::Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the caries process. To determine whether they differ in their responses to oral pathogens, we performed a systematic comparative analysis o...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700304

    authors: Staquet MJ,Durand SH,Colomb E,Roméas A,Vincent C,Bleicher F,Lebecque S,Farges JC

    更新日期:2008-03-01 00:00:00

  • The biocompatibility of dental implant materials measured in an animal model.

    abstract::The biocompatibility of two implant materials, vitallium and poly-methyl methacrylate (PMMA), was evaluated in an animal model in which bone formation and resorption are independent of each other. Neither material accelerated resorption, but formation was inhibited 12% by vitallium and 38% by PMMA. When three PMMA pre...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600010801

    authors: Garcia DA,Sullivan TM,O'Neill DM

    更新日期:1981-01-01 00:00:00

  • Parotid gland function and dentin apposition in rat molars.

    abstract::Previous studies have clearly established the down-regulating effect of a sucrose-rich diet on primary dentinogenesis in rat molars. Earlier observation of the negative effect of a high-sucrose diet on a parotid function involved in the control of intradentinal solute movement led us to hypothesize that parotid gland ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910208100407

    authors: Leonora J,Tjäderhane L,Tieche JM

    更新日期:2002-04-01 00:00:00

  • Caries experience in deciduous and permanent dentition of the same individuals.

    abstract::Caries of the permanent first molars of 5-year-old children was found to be associated with caries of their diciduous teeth. The sample consisted of 220 children whose permanent first molars had erupted. They were selected out of 965 children who were a representative sample of children attending compulsory kindergart...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550062001

    authors: Zadik D

    更新日期:1976-11-01 00:00:00

  • Cyclosporin a affects signaling events differentially in human gingival fibroblasts.

    abstract::Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). T...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910508400609

    authors: Bostrom A,Bharath H,Saulewicz A,Narayanan AS

    更新日期:2005-06-01 00:00:00

  • Microcracks in dental porcelain and their behavior during multiple firing.

    abstract::Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345960750070801

    authors: Mackert JR Jr,Williams AL

    更新日期:1996-07-01 00:00:00

  • High-temperature behavior of a Pd-Ag alloy for porcelain.

    abstract::The mechanism of formation of nodular material on the surface of a Pd-Ag-based alloy for porcelain during pre-porcelainization heat treatment was investigated using scanning electron microscopy, x-ray diffraction, quantitative metallography, and Auger electron spectroscopy. The nodules were found to form by a Nabarro-...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620121201

    authors: Mackert JR Jr,Ringle RD,Fairhurst CW

    更新日期:1983-12-01 00:00:00

  • A rheological study of the role of additives on the setting of glass-ionomer cements.

    abstract::The effects of various additives on the setting of the glass-ionomer cement system was studied by means of cone and plate viscometry. The action of (+)-tartaric acid, the most important additive, on the setting reaction depended on its concentration. Low concentrations accelerated the development of viscosity of the c...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345880670120101

    authors: Hill RG,Wilson AD

    更新日期:1988-12-01 00:00:00

  • Preliminary observations on the effect of mantle field radiotherapy on salivary flow rates in patients with Hodgkin's disease.

    abstract::Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reduct...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345880670021801

    authors: Bucher JA,Fleming TJ,Fuller LM,Keene HJ

    更新日期:1988-02-01 00:00:00

  • Genetics of human taste perception.

    abstract::Genetic approaches are rapidly yielding new information about our sense of taste. This information comes from both molecular studies of genes encoding taste receptors and other taste-signaling components, and from studies of inherited variation in taste abilities. Our understanding of bitter taste has advanced by comb...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/154405910408300603

    authors: Kim UK,Breslin PA,Reed D,Drayna D

    更新日期:2004-06-01 00:00:00

  • Initial subgingival colonization of 'pristine' pockets.

    abstract::The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910508400409

    authors: Quirynen M,Vogels R,Pauwels M,Haffajee AD,Socransky SS,Uzel NG,van Steenberghe D

    更新日期:2005-04-01 00:00:00

  • Artificial Intelligence in Dentistry: Chances and Challenges.

    abstract::The term "artificial intelligence" (AI) refers to the idea of machines being capable of performing human tasks. A subdomain of AI is machine learning (ML), which "learns" intrinsic statistical patterns in data to eventually cast predictions on unseen data. Deep learning is a ML technique using multi-layer mathematical...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034520915714

    authors: Schwendicke F,Samek W,Krois J

    更新日期:2020-07-01 00:00:00

  • The Oral Microbiota Is Modified by Systemic Diseases.

    abstract::Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studie...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034518805739

    authors: Graves DT,Corrêa JD,Silva TA

    更新日期:2019-02-01 00:00:00

  • The instantaneous hinge axis - its reproducibility and use as an indicator for dysfunction.

    abstract::This study investigated irregularities in hinge movement in 113 subjects. These irregularities were analyzed by computer with an instantaneous three-dimensional "screw axis method." The variation in hinge movement was measured by the dispersion of the hinge axis instant centers. Dispersion of instant centers was great...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345820610010301

    authors: Lupkiewicz SM,Gibbs CH,Mahan PE,Lundeen HC,Ariet M,Sinkewiz SL

    更新日期:1982-01-01 00:00:00

  • High-temperature X-ray diffraction measurement of sanidine thermal expansion.

    abstract::Dental porcelains that are designed to be fused to PFM (porcelain-fused-to-metal) alloys are formulated by their manufacturers to be closely matched in thermal expansion to these alloys. The high thermal expansion of the mineral leucite has been exploited to regulate porcelain expansion. Leucite, however, has been obs...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790081101

    authors: Mackert JR Jr,Twiggs SW,Williams AL

    更新日期:2000-08-01 00:00:00

  • Salivary proteins interact with dietary constituents to modulate tooth staining.

    abstract::Dietary components rich in polyphenols-for example, tea and red wine-are thought to cause tooth staining. In the present study, hydroxyapatite was used as a model of enamel for study of the influence of salivary proteins on the binding of different polyphenols to hydroxyapatite in vitro. Neither salivary protein pelli...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910508400113

    authors: Proctor GB,Pramanik R,Carpenter GH,Rees GD

    更新日期:2005-01-01 00:00:00

  • FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate.

    abstract::Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulat...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517750141

    authors: Xu J,Huang Z,Wang W,Tan X,Li H,Zhang Y,Tian W,Hu T,Chen YP

    更新日期:2018-05-01 00:00:00

  • The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol.

    abstract::The dental phenolic medicaments, eugenol and guaiacol, are partly similar in chemical structure to capsaicin, the pungent constituent of chili peppers, which selectively activates sensory neurons via a specific receptor. We have previously demonstrated that these phenolic compounds show capsaicin-like action. In the p...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345970760040501

    authors: Ohkubo T,Shibata M

    更新日期:1997-04-01 00:00:00

  • Bone regeneration in defects compromised by radiotherapy.

    abstract::Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034509352151

    authors: Hu WW,Ward BB,Wang Z,Krebsbach PH

    更新日期:2010-01-01 00:00:00

  • Anatomic and directional variation in the mechanical properties of the mandibular condyle in pigs.

    abstract::Stereologic studies of trabecular architecture suggest that the pig mandibular condyle is strongest when loaded supero-inferiorly, and that stress is concentrated in the antero-inferior region (Teng and Herring, 1995). To test these hypotheses, we investigated the uni-axial mechanical properties of 22 pig mandibular c...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345960750110501

    authors: Teng S,Herring SW

    更新日期:1996-11-01 00:00:00

  • COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain.

    abstract::When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515595043

    authors: Slade GD,Sanders AE,Ohrbach R,Bair E,Maixner W,Greenspan JD,Fillingim RB,Smith S,Diatchenko L

    更新日期:2015-09-01 00:00:00

  • Kinetics of cell proliferation and migration associated with orthodontically-induced osteogenesis.

    abstract::Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600021501

    authors: Roberts WE,Chase DC

    更新日期:1981-02-01 00:00:00

  • The presence of fucosyltransferases with different substrate specificity in human parotid saliva.

    abstract::Using glycoproteins and milk oligosaccharides as substrate acceptors, we demonstrated at least two fucosyltransferases in human parotid saliva. One enzyme transferred L-fucose from GDP-fucose to the C-3 position of N-acetylglucosamine or glucose residue of oligosaccharide chains, and the other transferred to the C-4 p...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620070701

    authors: Tamagawa H,Inoshita E,Shibata S,Shizukuishi S,Tsunemitsu A

    更新日期:1983-07-01 00:00:00