Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection.

Abstract:

:Although certain bacterial species appear to be risk factors for pain due to odontogenic infections, comparatively little is known about the potential mechanisms mediating this effect. In this study, we tested the hypothesis that trigeminal nociceptive neurons express the TLR4 or CD14 receptors, thus enabling sensory neurons to detect and respond to tissue levels of bacterial substances such as lipopolysaccharide (LPS). Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14. Moreover, human dental pulp collected from patients with caries lesions demonstrated co-localization of TLR4 and CD14, with markers of peripheral sensory neurons. Collectively, these studies indicate that the capsaicin-sensitive subclass of trigeminal nociceptors expresses TLR4 and CD14. These results indicate that pain due to bacterial infections may result, in part, from direct activation of nociceptors by bacterial products such as LPS.

journal_name

J Dent Res

authors

Wadachi R,Hargreaves KM

doi

10.1177/154405910608500108

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

49-53

issue

1

eissn

0022-0345

issn

1544-0591

pii

85/1/49

journal_volume

85

pub_type

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