Abstract：
:Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema. Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressure, and contribute to pain and irreversible tissue damage. Lipoteichoic acid (LTA) is an amphiphilic molecule from Gram-positive bacteria that has been associated with the pathogenesis of pulpitis. To investigate if LTA regulates expression of VEGF, we exposed mouse odontoblast-like cells (MDPC-23), undifferentiated pulp cells (OD-21), fibroblasts, or macrophages to streptococcal LTA, and evaluated VEGF expression by ELISA and RT-PCR. LTA induced up to a nine-fold increase in VEGF protein expression in macrophages, a 2.4-fold increase in MDPC-23, and a 1.6-fold increase in OD-21 as compared with controls. In contrast, LTA did not induce VEGF expression in fibroblasts. VEGF mRNA expression remained constant upon exposure to LTA, which suggests that VEGF regulation in these cells is primarily post-transcriptional. This work constitutes the first demonstration that lipoteichoic acid is sufficient to induce expression of a pro-angiogenic factor.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Telles PD,Hanks CT,Machado MA,Nör JEdoi
10.1177/154405910308200612keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
466-70issue
6eissn
0022-0345issn
1544-0591journal_volume
82pub_type
杂志文章abstract：:Dietary components rich in polyphenols-for example, tea and red wine-are thought to cause tooth staining. In the present study, hydroxyapatite was used as a model of enamel for study of the influence of salivary proteins on the binding of different polyphenols to hydroxyapatite in vitro. Neither salivary protein pelli...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400113
更新日期：2005-01-01 00:00:00
abstract：:Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650071601
更新日期：1986-07-01 00:00:00
abstract：:Branching morphogenesis is essential for the formation of salivary glands, kidneys, lungs, and many other organs during development, but the mechanisms underlying this process are not adequately understood. Microarray and other gene expression methods have been powerful approaches for identifying candidate genes that ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511429346
更新日期：2012-02-01 00:00:00
abstract：:The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590030501
更新日期：1980-03-01 00:00:00
abstract：:A new type of hydraulic cement has been developed. This cement consists of a mixture of cement powder and setting agent powder and therefore has only to be kneaded with a little amount of water when being used. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580050601
更新日期：1979-05-01 00:00:00
abstract：:The destabilizing effect of endodontic treatment upon teeth is still controversial. The purpose of this study was to investigate the effects of different steps of endodontic treatments upon the rigidity of teeth. Extracted untreated central maxillary anterior teeth were loaded (3.75 N), and deformations of the root we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500416
更新日期：2006-04-01 00:00:00
abstract：:Our observations confirm the previously reported observation that multinucleated cells develop within a two-week period in cat bone-marrow cultures. Calcitonin induces cytoplasmic contraction in these multinucleated cells, which indicates that they resemble osteoclasts. After seven days of culture, cat bone-marrow cul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650070201
更新日期：1986-07-01 00:00:00
abstract：:The object of the present study was an attempt to relate fluoride concentration in enamel, caries experience, and the degree of fluorosis in a community residing in an area with a high level of fluoride. A significant difference was found between the male and female samples for the F and D parameters. A positive corre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550012001
更新日期：1976-01-01 00:00:00
abstract：:The diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection relies on the detection of viral RNA by real-time reverse transcription polymerase chain reaction (rRT-PCR) performed with respiratory specimens, especially nasopharyngeal swabs. However, this procedure requires specialized medical...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520969670
更新日期：2021-02-01 00:00:00
abstract：:Laser-Raman spectra of synthetic apatites containing from zero to 12.4 wt% carbonate ions and enamel apatite are reported. Special attention is paid to the correlation between the intensities of the carbonate, phosphate, and hydroxyl modes and the carbonate content in the apatites. The data presented here indicate tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600031601
更新日期：1981-03-01 00:00:00
abstract：:The size of a bolus determines how it will be manipulated in the mouth and swallowed. We hypothesized that mucosal sensitivity would be important for masticatory function. The accuracy of solid object size perception, spatial acuity, and food particle size reduction during mastication were measured in 22 healthy adult...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300507
更新日期：2004-05-01 00:00:00
abstract：:The sagittal and frontal active envelope of border movement is applied regularly as a clinical tool in functional examinations of the human masticatory system. In contrast, the three-dimensional movement area has hardly been examined. Furthermore, the determinants of this area are not established unambiguously. In the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800100901
更新日期：2001-10-01 00:00:00
abstract：:The synthesis of many polycarboxylic acids is reported. An account is given of their stability in aqueous solution and the properties of cements formed by their reaction with ion-leachable glasses. A copolymer of acrylic and itaconic acids was found to combine several favorable characteristics. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590060801
更新日期：1980-06-01 00:00:00
abstract：:The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518822808
更新日期：2019-03-01 00:00:00
abstract：:A quantitative microprobe analysis was conducted on three commercial amalgams to determine the nature of the phases present. The presence of tin in the Ag-Hg phase (gamma1) was confirmed and Cu-3Sn was found in the original alloy particles. In the dispersant amalgam studied, little Sn-Hg phase (gamma-2) was found and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:Since the exposure of mutans streptococci to xylitol is known to select for xylitol-resistant (XR) natural mutants, the occurrence and long-term survival of such xylitol-resistant strains was evaluated in a cross-sectional sampling of participants of the Ylivieska xylitol study four years after the original two-year e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710110401
更新日期：1992-11-01 00:00:00
abstract：:The aim of the present study was to describe the patterns of dental fluorosis in the primary and the permanent dentition of children born and reared in two different fluoridated areas, one in which powdered milk suspended in tap water was commonly used (Narssaq, Greenland: 1.1 ppm fluoride in the water) and one in whi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670050501
更新日期：1988-05-01 00:00:00
abstract：:Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580101501
更新日期：1979-10-01 00:00:00
abstract：:The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes was induced with streptozotocin. Each group was further divided into 3 ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515581186
更新日期：2015-07-01 00:00:00
abstract：:With the objective of contributing to the understanding of factors influencing the characteristics of dentition, dental observations from 429 children and adult highland people of western Bolivia are described. Various age, sex, ethnic, and village differences are observed in malocclusion, dental caries, periodontal d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570030901
更新日期：1978-03-01 00:00:00
abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780061001
更新日期：1999-06-01 00:00:00
abstract：:The fluid in and gingival tissue lining periodontal pockets were collected from male patients undergoing periodontal therapy. The collagenolytic activity of the crevicular fluid, and the ability of the gingiva in culture to degrade (a) an exogenous collagen substrate, and (b) endogenous collagen newly synthesized and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580111601
更新日期：1979-11-01 00:00:00
abstract：:The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400409
更新日期：2005-04-01 00:00:00
abstract：:In periodontal surgery, healing after guided tissue regeneration (GTR) may be explained by differences in functional activities of gingival and periodontal ligament fibroblasts (GF and PDLF). Several studies in vitro have supported this hypothesis, but much remains to be defined. In the present work, gingival and peri...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750030601
更新日期：1996-03-01 00:00:00
abstract：:Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750070801
更新日期：1996-07-01 00:00:00
abstract：:The etiology of dental caries reflects a complex interplay of biochemical, microbial, genetic, social and physical environmental, and health-influencing behavioral factors. This review updates the literature on the efficacy of behavioral approaches to caries prevention for children up to 18 y of age. Included were stu...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515609034
更新日期：2016-01-01 00:00:00
abstract：:Modulation of the phosphoinositide signal transduction pathway by arachidonic acid (AA) in collagenase-dispersed rat submandibular acinar cells was investigated. The muscarinic agonist, carbachol, stimulated PIP2 hydrolysis and the generation of IP3 to five-fold the control levels. This response was inhibited by 75% o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710080101
更新日期：1992-08-01 00:00:00
abstract：:The remodeling of gingival tissue was measured by determining the incorporation of tritiated proline and the disappearance of tritium activity from proline and hydroxyproline for 18 days after administration of label. There was a rapid decrease in the tritium activity from gingiva which was paralleled by a decrease in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570023101
更新日期：1978-02-01 00:00:00
abstract：:Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519885362
更新日期：2020-01-01 00:00:00
abstract：:Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for hybrid layer degradation. Since chlorhexidine inhibits MMPs, we hypothesized that chlorhexidine would decelerate the loss of resin-dentin bonds. Class I preparations in extracted th...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600115
更新日期：2007-01-01 00:00:00
