Abstract：
:Modulation of the phosphoinositide signal transduction pathway by arachidonic acid (AA) in collagenase-dispersed rat submandibular acinar cells was investigated. The muscarinic agonist, carbachol, stimulated PIP2 hydrolysis and the generation of IP3 to five-fold the control levels. This response was inhibited by 75% on pre-treatment of cells with AA. The AA inhibitory effect was not duplicated by a range of prostaglandins and leukotrienes and was not reversed by blockers of the cyclo-oxygenase and lipoxygenase synthetic pathways, indicating that AA action was not mediated by eicosanoid metabolites. Additional experiments confirmed that the enzyme, protein kinase C, was also not a mediator of the AA effect. Arachidonic acid did not affect the uptake of radioactive inositol into acinar cells, but it did inhibit the incorporation of inositol into inositol phospholipids of the phosphoinositide cycle. In studies on inositol phospholipid turnover, AA alone reduced the level of PIP2 but not of PIP or PI. Under conditions of PI cycle stimulation with carbachol, AA significantly lowered PIP2 and PIP but not PI. These findings suggest that arachidonic acid may regulate the phosphoinositide response by inhibiting the synthetic phase of the cycle at a locus distal to PI generation.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Chung HC,Fleming Ndoi
10.1177/00220345920710080101keywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
1462-7issue
8eissn
0022-0345issn
1544-0591journal_volume
71pub_type
杂志文章abstract：:A number of studies have been made investigating the properties of dental prosthodontic soft polymer materials. In such materials, which are used as short-term denture soft liners, the polymer component is complexed with one or more plasticizers. This lowers the glass transition temperature, Tg, of the polymer by allo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700050201
更新日期：1991-05-01 00:00:00
abstract：:Caries of the permanent first molars of 5-year-old children was found to be associated with caries of their diciduous teeth. The sample consisted of 220 children whose permanent first molars had erupted. They were selected out of 965 children who were a representative sample of children attending compulsory kindergart...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550062001
更新日期：1976-11-01 00:00:00
abstract：:The effects of various additives on the setting of the glass-ionomer cement system was studied by means of cone and plate viscometry. The action of (+)-tartaric acid, the most important additive, on the setting reaction depended on its concentration. Low concentrations accelerated the development of viscosity of the c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670120101
更新日期：1988-12-01 00:00:00
abstract：:The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives. In many cases, pre-conditioning the restoratives in these liquids for one week produced swelling of the polymer matrix and considerable surface damage. The result...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640111601
更新日期：1985-11-01 00:00:00
abstract：:The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Variation in pulpal hemodynamics was attained by means of close intra-arterial injections of adrenergic agonists (NE ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203458506400415
更新日期：1985-04-01 00:00:00
abstract：:Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034514529150
更新日期：2014-07-01 00:00:00
abstract：:The aim of this meta-analysis, based on individual participant data from several studies, was to investigate the influence of patient-, materials-, and tooth-related variables on the survival of posterior resin composite restorations. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析,评审
doi：10.1177/0022034514544217
更新日期：2014-10-01 00:00:00
abstract：:Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750090901
更新日期：1996-09-01 00:00:00
abstract：:Knoop hardness measurements of UV-polymerized dental composites showed that, at a certain depth below the surface, the degree of cure rapidly decreases. The depth of cure was found to be critically dependent on the UV source and exposure time used. A theoretical model was derived which was in quantitative accord with ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590050901
更新日期：1980-05-01 00:00:00
abstract：:Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200505
更新日期：2003-05-01 00:00:00
abstract：:Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514534690
更新日期：2014-07-01 00:00:00
abstract：:In the past two decades, accumulated evidence has clearly demonstrated the inhibitory effects of laser irradiation on enamel demineralization, but the exact mechanisms of these effects remain unclear. The purpose of this study was to investigate the effects of low-energy CO2 laser irradiation on demineralization of bo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790091401
更新日期：2000-09-01 00:00:00
abstract：:The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, c...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034511434055
更新日期：2012-06-01 00:00:00
abstract：:In comparison with control rats. chronic administration of isoproterenol (IPR) caused enlargement of the parotid and submandibular glands and the synthesis of apparently new proteins, probably by acinar cells. The parotid and submandibular saliva secreted in response to methoxamine or IPR differed markedly in protein ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590062001
更新日期：1980-06-01 00:00:00
abstract：:Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduc...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034510373763
更新日期：2010-09-01 00:00:00
abstract：:Two independent cross-over studies investigated the possibility of enhanced early enamel lesion remineralization with the use of chewing gum. The first study involved a sorbitol-containing chewing gum, and the second, which had an identical protocol, tested a sucrose-containing chewing gum. In each study, 12 volunteer...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345920710120801
更新日期：1992-12-01 00:00:00
abstract：:Evaluation of long-term mechanical behavior of new types of restorations in clinical trials is time-consuming. A partial alternative can be found in experimental fatigue-testing, which simulates accelerated mechanical deterioration. The aim of this study was to determine the feasibility of using fatigue-testing of a c...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345920710050301
更新日期：1992-05-01 00:00:00
abstract：:Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345970760100901
更新日期：1997-10-01 00:00:00
abstract：:The oral microbiome is one of the most stable ecosystems in the body and yet the reasons for this are still unclear. As well as being stable, it is also highly diverse which can be ascribed to the variety of niches available in the mouth. Previous studies have focused on the microflora in disease-either caries or peri...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034520915486
更新日期：2020-06-01 00:00:00
abstract：:Ten cats were immunized with subcutaneous injections of keyhole limpet hemocyanin (KLH). After it was determined that the experimental animals had developed circulating antibodies to KLH, challenge doses of KLH were administered via the root canal system. The radiographic and histologic findings suggest that antigen-a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590011601
更新日期：1980-01-01 00:00:00
abstract：:Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and "4b", the latter being as yet unidentified in AMELX transcripts. To learn more about the evolutionary origin of these exons, we used an in silico approach to find th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511423399
更新日期：2012-01-01 00:00:00
abstract：:In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680121101
更新日期：1989-12-01 00:00:00
abstract：:The spatial relationship of the mandibular condyle to the temporal component of the TMJ is determined quantitatively from lateral tomograms using a new method of measuring specific areas of the joint space. Condyle position along the posteroanterior axis of the joint is expressed as a ratio of the posterior joint spac...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600010701
更新日期：1981-01-01 00:00:00
abstract：:The tissue-implant interfaces of functional and non-functional endosseous dental implants were compared histologically for up to one year post-operatively. Nonmineralized connective tissue zones (a "fibrous capsule") existed in all functional interfaces. Direct, or nearly direct, bone apposition to implants occurred i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580100201
更新日期：1979-10-01 00:00:00
abstract：:Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808701210
更新日期：2008-12-01 00:00:00
abstract：:The goal of this study was to assess the ability of a scintillation camera method to detect areas of active bone loss due to periodontitis. Technetium 99m methylene diphosphonate was used as the bone-seeking radiopharmaceutical. Bone-seeking radiopharmaceutical uptake (BSRU) was imaged and quantified in alveolar bone ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700010801
更新日期：1991-01-01 00:00:00
abstract：:To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514561657
更新日期：2015-02-01 00:00:00
abstract：:This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550050601
更新日期：1976-09-01 00:00:00
abstract：:Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513516979
更新日期：2014-03-01 00:00:00
abstract：:Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510375824
更新日期：2010-10-01 00:00:00
