Abstract：
:Although the tripeptides Glu-O-Phosphoserine-Tyr and Glu-O-Phosphoserine-Leu have been identified in embryonic bovine enamel proteins, 1, 2 the issue of whether both sequences occur in each of the phosphopeptides, or whether certain sequences occur in specific peptides only, has recently been resolved by isolating homogeneous samples of E33 and E44. All three of the Ser residues of both peptides are phosphorylated. All three in E3 are in the sequence Glu-O-Phosphoserine-Leu, and all three in E4 are in the sequence Glu-O-Phosphoserine-Tyr. It was not possible to sequence either of the polypeptide chains directly by automatic peptide sequencing. However, a partial sequence of E4 was constructed from data derived from peptides isolated after cyanogen bromide, trypsin and chymotrypsin digestions. The presence of Glu, Tyr and Leu adjacent to and near the O-Phosphoserine [Ser(L)] residues and the 2 degrees, 3 degrees and higher ordered structures of the enamel phosphopeptides may be important in calcium binding and mineralization.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Glimcher MJdoi
10.1177/00220345790580023101subject
Has Abstractpub_date
1979-03-01 00:00:00pages
790-809issue
Spec Issue Beissn
0022-0345issn
1544-0591journal_volume
58pub_type
杂志文章abstract：:Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910808700502
更新日期：2008-05-01 00:00:00
abstract：:Dental plaque collected from the label aspect of the anterior dentition of children harbored Neisseria that synthesized an extracellular iodophilic polysaccharide (EIP) from sucrose. Gas chromatograms of fully-acetylated EIP derivatives indicated that glucose (97%) and galactose (3%) were the only monosaccharide const...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610050101
更新日期：1982-05-01 00:00:00
abstract：:Macrophage colony-stimulating factor (CSF-1) is a key regulatory cytokine for amelogenesis, and ameloblasts synthesize CSF-1. We hypothesized that PDGF stimulates DNA synthesis and regulates CSF-1 in these cells. We determined the effect of PDGF on CSF-1 expression using MEOE-3M ameloblasts as a model. By RT-PCR, MEOE...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700105
更新日期：2008-01-01 00:00:00
abstract：:Adhesion of restorative and protective materials to dentin is an important requirement for operative and preventive dentistry. Wettability and roughness are dentin substrate conditions that are critical to establishing good adhesion. This study examined superficial and deep dentin for variations in water contact angle...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780091001
更新日期：1999-09-01 00:00:00
abstract：:It has been shown that a release of periosteal tension may augment the growth of a long bone; however, similar experiments in the mandible have produced equivocal results. For further definition of the role of periosteal tension in the growth of the mandibular condyle, 80 young female Sprague-Dawley rats were randomly...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690090201
更新日期：1990-09-01 00:00:00
abstract：:Dissolution of mercury from amalgams and some intermetallic compounds found in the amalgam structure, such as gamma 1, gamma 2, and beta 1, was examined during one week of aging in 0.9% NaCl solution at 37 degrees C. The amount of mercury released from gamma 1 (30.2 micrograms/cm2) was at least 13 times that released ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660010701
更新日期：1987-01-01 00:00:00
abstract：:The relative contribution of the matrix of dentin to the physical properties of dentin is unknown but thought to be small. The objective of this study was to test the hypothesis that the demineralized matrix of dentin contributes little to the strength of dentin by measuring and comparing the ultimate tensile strength...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730061201
更新日期：1994-06-01 00:00:00
abstract：:Bone resorption beneath a maxillary complete denture was simulated by the finite element method, assuming that a threshold of compressive strain exists in the alveolar bone above which the resorption occurred. The pattern of predicted resorption was observed when 100 N of force was applied to three positions occlusall...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680091601
更新日期：1989-09-01 00:00:00
abstract：:The synthesis of many polycarboxylic acids is reported. An account is given of their stability in aqueous solution and the properties of cements formed by their reaction with ion-leachable glasses. A copolymer of acrylic and itaconic acids was found to combine several favorable characteristics. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590060801
更新日期：1980-06-01 00:00:00
abstract：:Mechanical removal of oral biofilms is ubiquitously accepted as the best way to prevent caries and periodontal diseases. Removal effectiveness strongly depends on biofilm strength. To investigate the influence of hydrodynamics on oral biofilm strength, we grew single- and multi-species biofilms of Streptococcus oralis...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509344569
更新日期：2009-10-01 00:00:00
abstract：:Contact angle measurements on layers of bacteria were used to determine the bacterial surface free energy (gamma b) of a variety of oral streptococcal strains, both without and after being coated with human whole saliva. At least four isolates of each species, either freshly isolated or laboratory strains, were used. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640100501
更新日期：1985-10-01 00:00:00
abstract：:In a previous experiment, we found that masseter muscle spindles show functional plasticity after 5 to 15 days under increased occlusal vertical dimension (iOVD). In the present study, we hypothesized that spindle function would eventually recover if longer observation periods were allowed. Therefore, in this study we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500914
更新日期：2006-09-01 00:00:00
abstract：:Direct FA staining for S mutans serotypes may be performed on smears made from plaque or strain isolates and on colonies attached to agar plates of black membrane filters. Staining with single conjugates directed to S mutans serotypes (a to e) as well as with polyvalent a-, b-, d-, f-fluorescein label and c-, e-rhodam...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457605500126011
更新日期：1976-01-01 00:00:00
abstract：:One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034513490957
更新日期：2013-07-01 00:00:00
abstract：:Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514565647
更新日期：2015-03-01 00:00:00
abstract：:The balance between bone resorption and bone formation is vital for maintenance and regeneration of alveolar bone and supporting structures around teeth and dental implants. Tissue regeneration in the oral cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions. A goal for periodontal...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515618887
更新日期：2016-03-01 00:00:00
abstract：:Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain pre...
journal_title：Journal of dental research
pub_type： 传,历史文章,杂志文章
doi：10.1177/0022034510366677
更新日期：2010-07-01 00:00:00
abstract：:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit bud-stage developmental arrest of the mandibular molar t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517713710
更新日期：2017-09-01 00:00:00
abstract：:An oral radiotelemetric technique was used to determine whether a range of efficient buffers had the capacity to control the levels of hydrogen ions within dental plaque in the presence of sucrose. It was found that the buffers failed to control both the intensity and duration of the acid produced. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550052601
更新日期：1976-09-01 00:00:00
abstract：:The DMF index provides one source of information on past and present dental caries experience; however, important limitations hinder its ability to characterize fully the impact of dental caries. The purpose of this paper is to describe a measure of selected restoration and tooth conditions that supplements informatio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203459607502S06
更新日期：1996-02-01 00:00:00
abstract：:We explored the potential to diagnose Zika virus (ZIKV) infection by analyzing peptides in saliva during a convalescent phase of infection, long after resolution of acute disease. A 25-y-old woman clinically diagnosed with Zika fever in the first trimester was enrolled with her dizygotic twins for a 3-mo postnatal sam...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517723325
更新日期：2017-09-01 00:00:00
abstract：:Mutans streptococci (MS) are generally considered to be the principal etiological agent of dental caries. MS have two important virulence factors: cell- surface protein PAc and glucosyltransferases (GTFs). GTFs have two functional domains: an N-terminal catalytic sucrose-binding domain (CAT) and a C-terminal glucan-bi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509336727
更新日期：2009-05-01 00:00:00
abstract：:Candida albicans is an opportunistic fungal organism frequently detected in the oral cavity of children with severe early childhood caries (S-ECC). Previous studies suggested the cariogenic potential of C. albicans, in vitro and in vivo, and further demonstrated its synergistic interactions with Streptococcus mutans. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518790941
更新日期：2018-12-01 00:00:00
abstract：:The ability of adhesive resins to restore the physical properties of demineralized dentin has not been well-documented. The unfilled resins that are used for adhesion have relatively low moduli of elasticity and limited ability to increase dentin stiffness, although they may increase the ultimate tensile strength of d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740041001
更新日期：1995-04-01 00:00:00
abstract：:The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550041701
更新日期：1976-07-01 00:00:00
abstract：:Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibula...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600905
更新日期：2007-09-01 00:00:00
abstract：:The aims of this work were (a) to assess the oral bioavailability of fluoride delivered from dentifrices and (b) to test for a possible link between the results and clinical data obtained with the same dentifrices. Oral fluoride concentrations were measured in samples of saliva and plaque taken from seven subjects, af...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,评审
doi：10.1177/002203459207100S09
更新日期：1992-04-01 00:00:00
abstract：:Previous studies have shown that therapeutic pulsed ultrasound (pulsed) has superior stimulatory effect on bone fracture healing compared with continuous ultrasound (continuous). Our predictive hypothesis was that pulsed ultrasound can produce better bone formation during mandibular osteodistraction than continuous ul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808701018
更新日期：2008-10-01 00:00:00
abstract：:Cytotoxicity of fine cut amalgam was persistent until 24 hours after trituration in vitro, whereas cytotoxicity of spherical amalgam diminished more quickly. Increasing mercury content in spherical amalgam increased cytotoxicity. Possible reactions for the diminution of cytotoxicity of amalgams with time are discussed...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:During orofacial tissue development, the anterior and posterior regions of the Meckel's cartilage undergo mineralization, while the middle region undergoes degeneration. Despite the interesting and particular phenomena, the mechanisms that regulate the different fates of Meckel's cartilage, including the effects of bi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520960118
更新日期：2021-02-01 00:00:00
