Carbon nanotubes: directions and perspectives in oral regenerative medicine.

Abstract:

:One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT present remarkable mechanical, thermal, and electrical properties with easy functionalization capability and biocompatibility. In oral regenerative medicine, bone reconstruction is an essential requirement for functional rehabilitation of the stomatognathic system. Autologous bone still represents the gold standard graft material for bone reconstruction. However, the small amounts of bone available in donor regions, together with the high costs of surgeries, are critical aspects that hinder the selection of this procedure. Thus, CNT alone or combined with biopolymers have promise to be used as novel potential biomaterials for the restoration of bone defects. Indeed, recent evidence demonstrates CNT to be a feasible material that can increase the formation of bone in tooth sockets of rats. The purpose of this review is to summarize the recent developments in bone repair/regeneration with CNT or CNT-based composites. We further provide an overview of bone tissue engineering and current applications of biomaterials, especially of CNT, to enhance bone regeneration.

journal_name

J Dent Res

authors

Martins-Júnior PA,Alcântara CE,Resende RR,Ferreira AJ

doi

10.1177/0022034513490957

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

575-83

issue

7

eissn

0022-0345

issn

1544-0591

pii

0022034513490957

journal_volume

92

pub_type

杂志文章,评审
  • Analysis of Asgar-Mahler reaction zone in Dispersalloy amalgam by electron diffraction.

    abstract::Selected area reflection electron diffraction has been used to determine the phases present in the reaction zones surrounding the Ag-Cu eutectic dispersant in Dispersalloy amalgam. The experiments were carried out on two kinds of specimens, (1) Dispersalloy amalgam and (2) Dispersalloy amalgam using 30, 50, 75, and 10...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560090101

    authors: Okabe T,Mitchell R,Butts MB,Bosley JR,Fairhurst CW

    更新日期:1977-09-01 00:00:00

  • Tensile characterization of porcine temporomandibular joint disc attachments.

    abstract::The frequency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing the joint's function. The 6 discal attachments have not yet been systematically characterized under tension. Understanding their role in joint function may guide our study of TMJ pathologies, including disc displ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513494817

    authors: Murphy MK,Arzi B,Hu JC,Athanasiou KA

    更新日期:2013-08-01 00:00:00

  • Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential.

    abstract::Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780061001

    authors: Crowe DL,Milo GE,Shuler CF

    更新日期:1999-06-01 00:00:00

  • PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells.

    abstract::Protease-activated receptors (PARs) are G protein-coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 and PAR-2 gene expres...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517719415

    authors: Alvarez MMP,Moura GE,Machado MFM,Viana GM,de Souza Costa CA,Tjäderhane L,Nader HB,Tersariol ILS,Nascimento FD

    更新日期:2017-12-01 00:00:00

  • Measuring the effect of intra-oral implant rehabilitation on health-related quality of life in a randomized controlled clinical trial.

    abstract::The importance of assessing the impact of treatments for chronic conditions on an individual's quality of life has been well-established. In this randomized clinical trial, oral-health-related quality of life, measured with the Oral Health Impact Profile (OHIP), was compared between two groups of edentulous patients. ...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/00220345000790090401

    authors: Awad MA,Locker D,Korner-Bitensky N,Feine JS

    更新日期:2000-09-01 00:00:00

  • Determinants of requests for water fluoride assay among North Carolina dentists.

    abstract::Fluoride content of drinking water is an important criterion in prescribing fluoride supplements. The majority of practicing dentists and physicians prescribe fluoride supplements, yet many apparently are unaware of the fluoride levels in their patients' drinking water. Characteristics of North Carolina (NC) dentists,...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650011301

    authors: Levy SM,Rozier RG,Bawden JW

    更新日期:1986-01-01 00:00:00

  • Clinical and genetic analysis of a large North European Caucasian family affected by early-onset periodontitis.

    abstract::Genetic studies of early-onset periodontitis (EOP) are hampered by several factors. These include delayed onset of the trait, an upper age limit of expression of the disease, and lack of phenotypic information for edentulous family members. Segregation analyses of families with EOP support a major locus hypothesis but...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790031201

    authors: Hodge PJ,Teague PW,Wright AF,Kinane DF

    更新日期:2000-03-01 00:00:00

  • The relationship between clinical tooth status and receipt of sealants among child Medicaid recipients.

    abstract::This study investigated the association between caries status and sealant need at a prior survey and subsequent sealant use in a Medicaid program. Clinical data from a 1986-87 statewide epidemiological survey (N = 8026) representative of North Carolina (NC) schoolchildren (grades K-12) were linked with all NC Medicaid...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345970760120901

    authors: Robison VA,Rozier RG,Weintraub JA,Koch GG

    更新日期:1997-12-01 00:00:00

  • Influence of ketones on selected mechanical properties of resin composites.

    abstract::The present study investigated a concept for additional cross-linking of dental polymers, by which resistance to wear of resin composites might be increased. Bifunctional ketones were added to monomer mixtures, which were then made light-curing and loaded with filler. The monomer mixtures were varied with respect to t...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345920710111601

    authors: Peutzfeldt A,Asmussen E

    更新日期:1992-11-01 00:00:00

  • Mouse cellular cementum is highly dependent on growth hormone status.

    abstract::Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibula...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300107

    authors: Smid JR,Rowland JE,Young WG,Daley TJ,Coschigano KT,Kopchick JJ,Waters MJ

    更新日期:2004-01-01 00:00:00

  • Impact of Obesity on Orthodontic Tooth Movement in Adolescents: A Prospective Clinical Cohort Study.

    abstract::Obesity is a widespread chronic inflammatory disorder characterized by an increased overall disease burden and significant association with periodontitis. The aim of this prospective clinical cohort study was to investigate the effect of obesity on orthodontic tooth movement. Fifty-five adolescent patients (27 males, ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516688448

    authors: Saloom HF,Papageorgiou SN,Carpenter GH,Cobourne MT

    更新日期:2017-05-01 00:00:00

  • An original case of tin dental fillings from 18th century northern France.

    abstract::During the 18th century, France was the leader in the field of dentistry, exemplified by Pierre Fauchard (1678-1761), who was given the title "the father of modern dentistry" for his comprehensive work, Le Chirurgien Dentiste. This paper examines an 18th century dental treatment in a barely 50-year-old male whose body...

    journal_title:Journal of dental research

    pub_type: 历史文章,杂志文章

    doi:10.1177/0022034508329872

    authors: Bertrand B,Colard T,Lacoche C,Salomé JF,Vatteoni S

    更新日期:2009-03-01 00:00:00

  • Immunolocalization of PTCH protein in odontogenic cysts and tumors.

    abstract::The human patched gene (PTCH) functions in both embryologic development and tumor suppression. PTCH mutations have been found in odontogenic keratocysts. However, the expression and localization of the protein product of the gene have not been determined in odontogenic tumors and cysts. We investigated 68 odontogenic ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0810757

    authors: Barreto DC,Bale AE,De Marco L,Gomez RS

    更新日期:2002-11-01 00:00:00

  • A Comparative Assessment of Implant Site Viability in Humans and Rats.

    abstract::Our long-term objective is to devise methods to improve osteotomy site preparation and, in doing so, facilitate implant osseointegration. As a first step in this process, we developed a standardized oral osteotomy model in ovariectomized rats. There were 2 unique features to this model: first, the rats exhibited an os...

    journal_title:Journal of dental research

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0022034517742631

    authors: Chen CH,Pei X,Tulu US,Aghvami M,Chen CT,Gaudillière D,Arioka M,Maghazeh Moghim M,Bahat O,Kolinski M,Crosby TR,Felderhoff A,Brunski JB,Helms JA

    更新日期:2018-04-01 00:00:00

  • Effect of hydrogen sulfide and methyl mercaptan on the permeability of oral mucosa.

    abstract::Hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) are the volatile sulfur compounds (VSC) that were investigated for a possible role in the etiology of periodontal disease. The results show that the permeability of porcine non-keratinized sublingual mucosa is increased by up to 75% or 103% following exposure to H2S ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630071701

    authors: Ng W,Tonzetich J

    更新日期:1984-07-01 00:00:00

  • Formation of differentiated tissues in vivo by periodontal cell populations cultured in vitro.

    abstract::The periodontium contains heterogeneous mesenchymal cell populations with various differentiation potentials. The capacity of these cells for tissue formation as well as the origin of their precursors are still not entirely defined. In this study, cells originating from different periodontal tissues were cultured in v...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345950740051201

    authors: Lang H,Schüler N,Arnhold S,Nolden R,Mertens T

    更新日期:1995-05-01 00:00:00

  • Estimated drinking water fluoride exposure and risk of hip fracture: a cohort study.

    abstract::The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513506443

    authors: Näsman P,Ekstrand J,Granath F,Ekbom A,Fored CM

    更新日期:2013-11-01 00:00:00

  • Skin graft rejection after allogeneic tooth transplants in mice.

    abstract::Three strain combinations of in-bred mice representing strong and moderate histocompatibility barriers were used to determine if tooth allotransplants evoked strong or weak immunologic memory as measured by the second-set donor-strain skin graft technique. At issue was whether the anatomic site of engraftment could in...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630010901

    authors: Riviere GR

    更新日期:1984-01-01 00:00:00

  • Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia.

    abstract::Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515573273

    authors: Foster BL,Sheen CR,Hatch NE,Liu J,Cory E,Narisawa S,Kiffer-Moreira T,Sah RL,Whyte MP,Somerman MJ,Millán JL

    更新日期:2015-05-01 00:00:00

  • Nature and role of loosely bound fluoride in dental caries.

    abstract::This paper discusses loosely bound fluoride and its role in dental caries and prevention. Loosely bound fluoride (abbr. by Fa) is fluoride adsorbed onto enamel mineral crystallites. Several recent studies indicate that a high total level of fluoride in enamel does not guarantee protection against caries. This leads to...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/00220345900690S118

    authors: Arends J,Christoffersen J

    更新日期:1990-02-01 00:00:00

  • Nitric oxide signaling contributes to ectopic orofacial neuropathic pain.

    abstract::Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513509280

    authors: Sugiyama T,Shinoda M,Watase T,Honda K,Ito R,Kaji K,Urata K,Lee J,Ohara K,Takahashi O,Echizenya S,Iwata K

    更新日期:2013-12-01 00:00:00

  • Breastfeeding and Oral Health: Evidence and Methodological Challenges.

    abstract::Breastfeeding is a powerful health-promoting behavior. A 2016 Lancet global collaboration to review the health implications of breastfeeding was among the first to consider oral health outcomes. While a role was suggested for breastfeeding in preventing malocclusion, caries was the only included disease condition unfa...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034517738925

    authors: Peres KG,Chaffee BW,Feldens CA,Flores-Mir C,Moynihan P,Rugg-Gunn A

    更新日期:2018-03-01 00:00:00

  • Roles of the primary cilium component Polaris in synchondrosis development.

    abstract::Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient in Polaris, a critical primary cilium component, in cartilage. Mutant post-natal cranial bases were deformed, and their synchondrosis g...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034509337775

    authors: Ochiai T,Nagayama M,Nakamura T,Morrison T,Pilchak D,Kondo N,Hasegawa H,Song B,Serra R,Pacifici M,Koyama E

    更新日期:2009-06-01 00:00:00

  • Molar intercuspal dimensions: genetic input to phenotypic variation.

    abstract::Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910308200505

    authors: Townsend G,Richards L,Hughes T

    更新日期:2003-05-01 00:00:00

  • Electric-current-assisted application of self-etch adhesives to dentin.

    abstract::The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910608501205

    authors: Breschi L,Mazzoni A,Pashley DH,Pasquantonio G,Ruggeri A,Suppa P,Mazzotti G,Di Lenarda R,Tay FR

    更新日期:2006-12-01 00:00:00

  • Hard tissue formation in subcutaneously transplanted rat dental pulp.

    abstract::While dental pulp appears to be able to form mineralized matrices that do not always resemble dentin, the precise characteristics of the hard tissue and the mechanism of its induction remain unknown. Therefore, we evaluated hard tissue induced by transplantation of pulp into subcutaneous tissue. Seven days after trans...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910708600515

    authors: Hosoya A,Nakamura H,Ninomiya T,Hoshi K,Yoshiba K,Yoshiba N,Takahashi M,Okabe T,Sahara N,Yamada H,Kasahara E,Ozawa H

    更新日期:2007-05-01 00:00:00

  • Expression of resolvin D1 biosynthetic pathways in salivary epithelium.

    abstract::Resolvins are potent anti-inflammatory mediators derived from ω-3 fatty acids. Results from our previous studies indicated that resolvin D1 (RvD1) blocks pro-inflammatory responses in salivary glands. Furthermore, RvD1 enhances salivary epithelial integrity, demonstrating its potential use for the restoration of saliv...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513519108

    authors: Leigh NJ,Nelson JW,Mellas RE,Aguirre A,Baker OJ

    更新日期:2014-03-01 00:00:00

  • A novel role for Twist-1 in pulp homeostasis.

    abstract::The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotyp...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910708601007

    authors: Galler KM,Yasue A,Cavender AC,Bialek P,Karsenty G,D'Souza RN

    更新日期:2007-10-01 00:00:00

  • Selection of an experimental unit in rat caries studies.

    abstract::In two separate experiments, none of the 14 subunits examined consistently ranked dentifrices similarly to the ranking obtained when the individual rat was used as the experimental unit. Arbitrarily dividing the rat into subunits and then comparing results among these subunits may lead to false conclusions since the r...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550032901

    authors: Briner WW

    更新日期:1976-05-01 00:00:00

  • Prostaglandin as a mediator of bone resorption induced by experimental tooth movement in rats.

    abstract::Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment. Prostaglandin E1 or E2 solutions injected in gingiva lying near the upper first molar caused the appearance of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345800590101301

    authors: Yamasaki K,Miura F,Suda T

    更新日期:1980-10-01 00:00:00