Abstract:
:The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins. Much like its more famous sibling, the biological role of p63 is quite complex, with wide-ranging effects on development, differentiation, and cellular lineage choices. The crucial function of p63 is epitomized by the striking phenotype of p63 knockout mice. These animals have a profound block in the development of stratified epithelia and aplasia of multiple ectodermal appendages, as well as orofacial clefting and limb defects. Remarkably, a similar spectrum of phenotypic alterations is observed in human syndromes resulting from Tp63 gene mutations. p63 is an important hub in the transcriptional and signaling networks of epithelial cells; thus, it is not surprising that dysregulation of this transcription factor is associated with squamous cell carcinoma. Finally, as a testament to the growing repertoire of p63-associated diseases, autoantibodies to p63 are associated with chronic ulcerative stomatitis, an oral immunologically mediated disease. Over the past decade, our understanding of the broad biologic and pathophysiological roles of p63 has grown significantly. In this review, we discuss the molecular attributes of Tp63 and the clinical consequences of Tp63 dysregulation, particularly as it pertains to oral tissues.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Romano RA,Solomon LW,Sinha Sdoi
10.1177/0022034511411302subject
Has Abstractpub_date
2012-02-01 00:00:00pages
125-32issue
2eissn
0022-0345issn
1544-0591pii
0022034511411302journal_volume
91pub_type
杂志文章,评审abstract::The effects of different doses of p-tyramine injected i.v. and i.p. on salivary flow rates and proteins secreted by the submandibular glands of rats were studied with and without various types of autonomic blockers and two enzyme inhibitors. The salivary flow rates and the amounts of protein secreted progressively inc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720051101
更新日期:1993-05-01 00:00:00
abstract::The object of the present study was an attempt to relate fluoride concentration in enamel, caries experience, and the degree of fluorosis in a community residing in an area with a high level of fluoride. A significant difference was found between the male and female samples for the F and D parameters. A positive corre...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550012001
更新日期:1976-01-01 00:00:00
abstract::Several studies have shown that surgical detachment of marginal gingiva close to the cervical cementum of molar teeth in a rat mandible is a distinct stimulus for alveolar bone resorption. Recently, we found that P2X4, an ATP-receptor, is significantly up-regulated in marginal gingival cells soon after surgery. We hyp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600214
更新日期:2007-02-01 00:00:00
abstract::Although certain bacterial species appear to be risk factors for pain due to odontogenic infections, comparatively little is known about the potential mechanisms mediating this effect. In this study, we tested the hypothesis that trigeminal nociceptive neurons express the TLR4 or CD14 receptors, thus enabling sensory ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500108
更新日期:2006-01-01 00:00:00
abstract::It is claimed that dental fluorosis in both deciduous and permanent teeth is increasing in fluoridated and non-fluoridated communities. What is unclear is whether fluoride-induced enamel opacities in the deciduous dentition are associated with the subsequent appearance of enamel defects in the permanent dentition. The...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750040301
更新日期:1996-04-01 00:00:00
abstract::A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a re...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560011601
更新日期:1977-01-01 00:00:00
abstract::Damage to the dentin matrix investigates the proliferation and mobilization of dental progenitor cells to the injury site, the mechanisms of which are not defined. EphB receptors and ephrin-B ligands expressed within the perivascular niche of dental pulp have been implicated following tooth injury. We propose that ele...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509342363
更新日期:2009-09-01 00:00:00
abstract::The synchronized cyrstal dissolution hypothesis previously proposed to explain the unusual dissolution behavior of human dental enamel and hydroxyapatite in partially saturated acidic media has been critically examined with dissolution-dialysis transport experiments. The findings are in accord with the hypothesis. A m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560040701
更新日期:1977-04-01 00:00:00
abstract::The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590030501
更新日期:1980-03-01 00:00:00
abstract::The purpose of this study was to determine the role of saliva-derived biomarkers and periodontal pathogens during periodontal disease progression (PDP). One hundred human participants were recruited into a 12-month investigation. They were seen bi-monthly for saliva and clinical measures and bi-annually for subtractio...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/0022034511399908
更新日期:2011-06-01 00:00:00
abstract::Although the occlusal vertical dimension (OVD) is strictly controlled, the neuronal mechanism of its regulation is still unclear. We hypothesize that neurons in the trigeminal mesencephalic nucleus (MesV) play an important role in the regulation of the OVD, because the MesV receives the projection from jaw-closing mus...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200715
更新日期:2003-07-01 00:00:00
abstract::It was recently reported that human periapical cysts (hPCys), a commonly occurring odontogenic cystic lesion of inflammatory origin, contain mesenchymal stem cells (MSCs) with the capacity for self-renewal and multilineage differentiation. In this study, periapical inflammatory cysts were compared with dental pulp to ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515570316
更新日期:2015-06-01 00:00:00
abstract::Light propagation in human dentin exhibits a strong directional dependence featuring the long-known optical magnification property. We hypothesized that this anisotropic effect is caused by multiple scattering at the dentin tubules, and not by fiberoptic effects, as had been previously assumed. We performed measuremen...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501017
更新日期:2006-10-01 00:00:00
abstract::Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515572190
更新日期:2015-04-01 00:00:00
abstract::Sintered samples of modifying porcelains of various colors and manufacturers were analyzed using reflectance spectrophotometry. Color designations are reported according to practices of the Commission Internationale de l'Eclairage (International Commission for Illumination), and color names were assigned based on a me...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610030801
更新日期:1982-03-01 00:00:00
abstract::The DMF index provides one source of information on past and present dental caries experience; however, important limitations hinder its ability to characterize fully the impact of dental caries. The purpose of this paper is to describe a measure of selected restoration and tooth conditions that supplements informatio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/002203459607502S06
更新日期:1996-02-01 00:00:00
abstract::Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514534690
更新日期:2014-07-01 00:00:00
abstract::Due, in part, to the unique structure of the tooth, dental pain is initiated via distinct mechanisms. Here we review recent advances in our understanding of inflammatory tooth pain and discuss 3 hypotheses proposed to explain dentinal hypersensitivity: The first hypothesis, supported by functional expression of temper...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034513501877
更新日期:2013-11-01 00:00:00
abstract::In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660031401
更新日期:1987-03-01 00:00:00
abstract::Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200406
更新日期:2003-04-01 00:00:00
abstract::Lingual amylase and lingual lipase, two digestive enzymes that are secreted from lingual serous glands (von Ebner's), were simultaneously purified from rat lingual serous glands with hydrophobic chromatography used as the final step. This method, previously developed for the purification of lingual lipase, includes ho...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680020801
更新日期:1989-02-01 00:00:00
abstract:UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512463241
更新日期:2013-01-01 00:00:00
abstract::Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or impl...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034511402207
更新日期:2011-12-01 00:00:00
abstract::Current challenges in adhesive dentistry include over-hydrophilic bonding formulations, which facilitate water percolation through the hybrid layer and result in unreliable bonded interfaces. This study introduces nanogel-modified adhesives as a way to control the material's hydrophobic character without changing the ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034511426573
更新日期:2012-02-01 00:00:00
abstract::Much research has been devoted to the study of etched enamel, since it is critical to bonding. Currently, there are no precise data regarding the etched-enamel specific surface area. The aim of this study was to characterize, by two different methods, the surface of human dental enamel in vitro after being etched. It ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700607
更新日期:2008-06-01 00:00:00
abstract::In mineralizing hamster molars, the influence of several inhibitors on p-NPP-ase has been demonstrated, and compared with their effect on PPi-ase, known to belong to the same enzyme. Whereas the latter activity is much more physiological, p-NPP is a better substrate to distinguish between the effects of bivalent catio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560102701
更新日期:1977-10-01 00:00:00
abstract::Cementum forms the interface between root dentin and periodontal ligament through which periodontal connective tissue is attached to root surfaces. We have examined how cementum components influence the biological activities of gingival fibroblasts. Cementum was harvested from freshly extracted human teeth and extract...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660082301
更新日期:1987-08-01 00:00:00
abstract::The uptake patterns of 90Sr in developing rat molar enamel were studied in vivo and in vitro. Autoradiographic methods were used that preclude loss or translocation of tracers associated with water-soluble compounds in the sections. In eight-day-old rats injected with the tracer, 90Sr uptake in the enamel was signific...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590121301
更新日期:1980-12-01 00:00:00
abstract::The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/154405910208100305
更新日期:2002-03-01 00:00:00
abstract::Three dental amalgams were investigated to determine if their abrasion resistance was significantly affected by different packing pressures. Abrasive wear tests were performed on a machine designed to test materials under conditions similar to masticatory function. The results show that the abrasion resistance of the ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560060901
更新日期:1977-06-01 00:00:00