Roles of the primary cilium component Polaris in synchondrosis development.

Abstract:

:Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient in Polaris, a critical primary cilium component, in cartilage. Mutant post-natal cranial bases were deformed, and their synchondrosis growth plates were disorganized. Expression of Indian hedgehog, Patched-1, collagen X, and MMP-13 was reduced and accompanied by decreases in endochondral bone. Interestingly, there was excessive intramembranous ossification along the perichondrium, accompanied by excessive Patched-1 expression, suggesting that Ihh distribution was wider and responsible for such excessive response. Indeed, expression of heparan sulfate proteoglycans (HS-PGs), normally involved in restricting hedgehog distribution, was barely detectable in mutant synchondroses. Analyses of the data provides further evidence for the essential roles of primary cilia and hedgehog signaling in cranial base development and chondrocyte maturation, and point to a close interdependence between cilia and HS-PGs to delimit targets of hedgehog action in synchondroses.

journal_name

J Dent Res

authors

Ochiai T,Nagayama M,Nakamura T,Morrison T,Pilchak D,Kondo N,Hasegawa H,Song B,Serra R,Pacifici M,Koyama E

doi

10.1177/0022034509337775

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

545-50

issue

6

eissn

0022-0345

issn

1544-0591

pii

88/6/545

journal_volume

88

pub_type

杂志文章
  • Mineralized tissue formation by BMP2-transfected pulp stem cells.

    abstract::Previously, in vitro differentiation of odontoblasts was shown for dental pulp stem cells (DPSCs) transfected with bone morphogenetic protein-2 (Bmp2). For this study, we hypothesized that such cells also show potential for mineralized tissue formation in vivo. DPSCs were transfected with Bmp2 and seeded onto a cerami...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034509346258

    authors: Yang X,van der Kraan PM,Bian Z,Fan M,Walboomers XF,Jansen JA

    更新日期:2009-11-01 00:00:00

  • A review of potential new diagnostic modalities for caries lesions.

    abstract::This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which have been proposed in the last few years, in addition to those that are gaining some commercial exposure and clinical a...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/154405910408301s18

    authors: Hall A,Girkin JM

    更新日期:2004-01-01 00:00:00

  • The epidemiology of root surface caries.

    abstract::Although a secular decline is being seen in coronal caries in children in industrialized countries, there appears to be a relatively high prevalence of root caries, with chronologically older adults exhibiting the highest prevalences. This paper reviews the descriptive and analytical epidemiology of root caries as fou...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/00220345900690051901

    authors: Beck J

    更新日期:1990-05-01 00:00:00

  • Purification of lingual amylase from serous glands of rat tongue and characterization of rat lingual amylase and lingual lipase.

    abstract::Lingual amylase and lingual lipase, two digestive enzymes that are secreted from lingual serous glands (von Ebner's), were simultaneously purified from rat lingual serous glands with hydrophobic chromatography used as the final step. This method, previously developed for the purification of lingual lipase, includes ho...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680020801

    authors: Field RB,Spielman AI,Hand AR

    更新日期:1989-02-01 00:00:00

  • Matrix Gla protein inhibition of tooth mineralization.

    abstract::Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700907

    authors: Kaipatur NR,Murshed M,McKee MD

    更新日期:2008-09-01 00:00:00

  • A within-subject comparison of mandibular long-bar and hybrid implant-supported prostheses: psychometric evaluation and patient preference.

    abstract::Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章

    doi:10.1177/00220345970760100901

    authors: Tang L,Lund JP,Taché R,Clokie CM,Feine JS

    更新日期:1997-10-01 00:00:00

  • Osteoprotective Effects of Estrogen in the Maxillary Bone Depend on ERα.

    abstract::Estrogen deficiency results in disruption of maxillary alveolar bone microarchitecture. Most of the actions of estrogen in long bones occur via estrogen receptor α (ERα). However, the function of ERα in the maxillary bone has not been defined. We aimed to investigate the role and underlying mechanisms of ERα in the ph...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516633154

    authors: Macari S,Ajay Sharma L,Wyatt A,Knowles P,Szawka RE,Garlet GP,Grattan DR,Dias GJ,Silva TA

    更新日期:2016-06-01 00:00:00

  • P2X4 is up-regulated in gingival fibroblasts after periodontal surgery.

    abstract::Several studies have shown that surgical detachment of marginal gingiva close to the cervical cementum of molar teeth in a rat mandible is a distinct stimulus for alveolar bone resorption. Recently, we found that P2X4, an ATP-receptor, is significantly up-regulated in marginal gingival cells soon after surgery. We hyp...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910708600214

    authors: Binderman I,Bahar H,Jacob-Hirsch J,Zeligson S,Amariglio N,Rechavi G,Shoham S,Yaffe A

    更新日期:2007-02-01 00:00:00

  • Contraction stress in dentin adhesives bonded to dentin.

    abstract::Adhesives cured under constrained conditions develop contraction stresses. We hypothesized that, with dentin as a bonding substrate, the stress would reach a maximum, followed by a continuous decline. Stress development was determined with a tensilometer for two total-etch systems and two systems with self-etching pri...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910608500808

    authors: Hashimoto M,de Gee AJ,Kaga M,Feilzer AJ

    更新日期:2006-08-01 00:00:00

  • In vivo and in vitro study of 90Sr in developing rat molar enamel.

    abstract::The uptake patterns of 90Sr in developing rat molar enamel were studied in vivo and in vitro. Autoradiographic methods were used that preclude loss or translocation of tracers associated with water-soluble compounds in the sections. In eight-day-old rats injected with the tracer, 90Sr uptake in the enamel was signific...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345800590121301

    authors: White BA,Deaton TG,Bawden JW

    更新日期:1980-12-01 00:00:00

  • Effect of chlorhexidine-fluoride applications without and with Sr and Zn on caries, plaque, and gingiva in rats.

    abstract::Molar teeth of four groups of Osborne-Mendel rats, kept on a cariogenic diet, were treated once per day for 48 days with either distilled water (solution C), a solution containing 0.05% chlorhexidine gluconate and 0.04% NaF, pH 5.8 (solution CXF), CXF plus 1000 ppm Sr (solution CXFS), or CXFS plus 1000 ppm Zn (solutio...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630100401

    authors: Luoma H,Seppä L,Koskinen M,Syrjänen S

    更新日期:1984-10-01 00:00:00

  • The resistance and adaptation of selected oral bacteria to mercury and its impact on their growth.

    abstract::Selected strains of oral Streptococcus and Actinomyces have been tested for their ability to grow in the presence of mercury. Strains were tested for growth on a semi-defined medium with low mercury-binding characteristics. Sensitivities were initially measured on agar plates, and subsequently, selected strains were g...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345930720091201

    authors: Lyttle HA,Bowden GH

    更新日期:1993-09-01 00:00:00

  • Antigens and surface components associated with virulence of Actinomyces viscosus.

    abstract::We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/002203457605500111011

    authors: Hammond BF,Steel CF,Peindl KS

    更新日期:1976-01-01 00:00:00

  • Production of colony-stimulating factor in human dental pulp fibroblasts.

    abstract::Class II major histocompatilibity complex (MHC)-expressing cells are usually distributed in dental pulp, and it was postulated that the colony-stimulating factor (CSF) derived from dental pulp fibroblasts contributes to the migration of class II MHC-expressing cells into pulp tissue. This study aimed to investigate th...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910308200204

    authors: Sawa Y,Horie Y,Yamaoka Y,Ebata N,Kim T,Yoshida S

    更新日期:2003-02-01 00:00:00

  • Lasers for the treatment of dentin hypersensitivity: a meta-analysis.

    abstract::This systematic review and meta-analysis assessed the efficacy of lasers in reducing dentin hypersensitivity (DH) as compared with placebo or no treatment. Seven electronic databases and a manual search resulted in 2,538 unique publications. After selection, 13 studies were included in the meta-analysis. A CONSORT-bas...

    journal_title:Journal of dental research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/0022034513487212

    authors: Sgolastra F,Petrucci A,Severino M,Gatto R,Monaco A

    更新日期:2013-06-01 00:00:00

  • Prevalence and need for replacement of amalgam and composite restorations in Dutch adults.

    abstract::In 1986, the first nationwide epidemiological survey of adult oral health and attitudes to oral health care was carried out in The Netherlands. One of the aims of this study was to evaluate the prevalence and the quality (in terms of need for replacement) of amalgam and composite restorations in the Dutch adult popula...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345900690060901

    authors: Kroeze HJ,Plasschaert AJ,van 't Hof MA,Truin GJ

    更新日期:1990-06-01 00:00:00

  • Randomized Clinical Trial on Sodium Fluoride with Tricalcium Phosphate.

    abstract::This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034520952031

    authors: Chen KJ,Gao SS,Duangthip D,Lo ECM,Chu CH

    更新日期:2021-01-01 00:00:00

  • Chlorhexide and fluoride in prevention of plaque and caries in hamsters.

    abstract::The effect of combined administration of chlorhexidine and fluoride in the drinking water of hamsters on plaque and caries prevention was studied. Plaque indices of the hamsters receiving chlorhexidine either alone or simultaneously with fluoride were significantly lower than those of the control and fluoride only tre...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560111401

    authors: Brayer L,Gedalia I,Gover A

    更新日期:1977-11-01 00:00:00

  • Reducing Indigenous Oral Health Inequalities: A Review from 5 Nations.

    abstract::Indigenous populations around the world experience a disproportionate burden in terms of oral diseases and conditions. These inequalities are likely due to a complex web of social determinants that includes poverty, historical consequences of colonialism, social exclusion, government policies of assimilation, cultural...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034518763605

    authors: Tiwari T,Jamieson L,Broughton J,Lawrence HP,Batliner TS,Arantes R,Albino J

    更新日期:2018-07-01 00:00:00

  • Effect of nitric oxide on the recovery of the hypofunctional periodontal ligament.

    abstract::The relationship between occlusal stimuli and a hypofunctional periodontal ligament (PDL) structure has been reported, though changes in occlusal recovery conditions were still unclear. Nitric oxide (NO) produced by NO synthase (NOS) is considered a factor for vascular and immune system control, and it increases accor...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300413

    authors: Watarai H,Warita H,Soma K

    更新日期:2004-04-01 00:00:00

  • Effect of local vs. systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the jaw.

    abstract::Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without com...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034512472335

    authors: Abtahi J,Agholme F,Sandberg O,Aspenberg P

    更新日期:2013-03-01 00:00:00

  • Molecular and cellular mechanisms that lead to Candida biofilm formation.

    abstract::Fungal infections in the oral cavity are mainly caused by C. albicans, but other Candida species are also frequently identified. They are increasing in prevalence, especially in denture-wearers and aging people, and may lead to invasive infections, which have a high mortality rate. Attachment to mucosal tissues and to...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034508329273

    authors: ten Cate JM,Klis FM,Pereira-Cenci T,Crielaard W,de Groot PW

    更新日期:2009-02-01 00:00:00

  • Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential.

    abstract::Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780061001

    authors: Crowe DL,Milo GE,Shuler CF

    更新日期:1999-06-01 00:00:00

  • Single-channel recordings of TREK-1 K+ channels in periodontal ligament fibroblasts.

    abstract::The periodontal ligament (PDL) works as a suspensory ligament when external mechanical stress is placed on the teeth. PDL fibroblasts, the principal cells in the PDL, are responsible for many PDL functions. We hypothesized that mechanosensitive ion channels are present in human PDL fibroblasts, which are capable of re...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910608500716

    authors: Ohara A,Saeki Y,Nishikawa M,Yamamoto Y,Yamamoto G

    更新日期:2006-07-01 00:00:00

  • Fibromodulin and Biglycan Modulate Periodontium through TGFβ/BMP Signaling.

    abstract::A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034514541126

    authors: Wang L,Foster BL,Kram V,Nociti FH Jr,Zerfas PM,Tran AB,Young MF,Somerman MJ

    更新日期:2014-08-01 00:00:00

  • High-Frequency Ultrasound Imaging for Examination of Early Dental Caries.

    abstract::The extent of dental tissue destruction during the treatment of white spot lesions (WSLs) increases with the severity of the lesion. If the depth and shape of WSLs can be predicted with a noninvasive diagnostic method before dental caries treatment, more conservative interventions can be planned. Given the superiority...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034518811642

    authors: Kim J,Shin TJ,Kong HJ,Hwang JY,Hyun HK

    更新日期:2019-03-01 00:00:00

  • Natural defenses against Candida colonization breakdown in the oral cavities of the elderly.

    abstract::Candida colonization of the oral cavity increases in the elderly. A major predisposing condition is denture use, which also increases in the elderly. To test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780040601

    authors: Lockhart SR,Joly S,Vargas K,Swails-Wenger J,Enger L,Soll DR

    更新日期:1999-04-01 00:00:00

  • Experimental ridge augmentation with porous hydroxyapatite implants.

    abstract::A new hydroxyapatite ceramic implant material for restoration of atrophic edentulous ridges was tested in a canine animal model. The structure of this material is unique, in that it is produced from the skeleton of a coral, and in that it is penetrated by a uniform network of interconnected pores. Results indicate tha...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620021301

    authors: Piecuch JF,Topazian RG,Skoly S,Wolfe S

    更新日期:1983-02-01 00:00:00

  • Intrauterine hormone effects on tooth dimensions.

    abstract::The human dentition is a complex adaptive system that is influenced by genetic, epigenetic, and environmental factors. Within this system, is sexual dimorphism related to the growth promotion of the Y chromosome, or to hormonal influences, or both? This study is the first to investigate both primary and permanent toot...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513484934

    authors: Ribeiro DC,Brook AH,Hughes TE,Sampson WJ,Townsend GC

    更新日期:2013-05-01 00:00:00

  • Contributions of three glycosyltransferases to sucrose-dependent adherence of Streptococcus mutans.

    abstract::Streptococcus mutans produces 3 types of glucosyltransferase (GTF), whose cooperative action is considered to be essential for its cellular adherence to the tooth surface. However, the precise mechanisms for synthesizing adhesive glucans and the specific roles of each GTF in cellular adherence to smooth surfaces have ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800071401

    authors: Ooshima T,Matsumura M,Hoshino T,Kawabata S,Sobue S,Fujiwara T

    更新日期:2001-07-01 00:00:00