Antigens and surface components associated with virulence of Actinomyces viscosus.

Abstract:

:We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing some resemblance to the peptidoglycan. Other data indicate a positive correlation between the presence of this antigen and an extrachromosomal piece of DNA having most of the properties of a bacterial plasmid. The specific function of the 6-DOT antigen in disease production is not known, but its clear association with virulent strains suggests the possibility of monitoring specific populations of oral actinomycetes.

journal_name

J Dent Res

authors

Hammond BF,Steel CF,Peindl KS

doi

10.1177/002203457605500111011

keywords:

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

A19-25

eissn

0022-0345

issn

1544-0591

journal_volume

55

pub_type

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