Abstract：
:The effects of different doses of p-tyramine injected i.v. and i.p. on salivary flow rates and proteins secreted by the submandibular glands of rats were studied with and without various types of autonomic blockers and two enzyme inhibitors. The salivary flow rates and the amounts of protein secreted progressively increased with increasing doses injected both i.v. and i.p., whereas they were dramatically reduced with all autonomic blockers except the lowest doses of beta-blockers, atropine, and yohimbine. Salivation in response to p-tyramine injected i.v. and i.p. was completely abolished by simultaneous injections of both prazosin and propranolol. The concentration of protein was not dose-dependent and was not reduced by yohimbine and phenoxybenzamine at almost all doses used. However, prazosin significantly increased the protein concentration. Protease activities were dose-dependent but were significantly reduced with alpha-blockers other than yohimbine, and with most beta-blockers. The proteins secreted in response to p-tyramine at all doses injected i.v. and i.p. were of the alpha-type except with the lowest dose injected i.p. However, the alpha-type was completely replaced by the beta-type in the presence of all alpha-blockers except yohimbine, but not with beta-blockers, atropine, or two enzyme inhibitors. Pargyline, a monoamine-oxidase inhibitor, but not disulfiram, a dopamine-beta-hydroxylase inhibitor, affected all parameters except the type of protein. Thus, p-tyramine may activate both the alpha 1- and beta 1-adrenoceptors in the submandibular glands of rats directly or indirectly.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Okina A,Hidaka S,Tashiro M,Abe Kdoi
10.1177/00220345930720051101subject
Has Abstractpub_date
1993-05-01 00:00:00pages
897-906issue
5eissn
0022-0345issn
1544-0591journal_volume
72pub_type
杂志文章abstract：:The authors tested the hypothesis that obstructive sleep apnea (OSA) signs/symptoms are associated with the occurrence of temporomandibular disorder (TMD), using the OPPERA prospective cohort study of adults aged 18 to 44 years at enrollment (n = 2,604) and the OPPERA case-control study of chronic TMD (n = 1,716). In ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513488140
更新日期：2013-07-01 00:00:00
abstract：:The purpose of this investigation was to determine whether chlorhexidine combined with copper would exert a synergistic, growth-inhibitory effect against selected oral bacteria. Actinomyces viscosus, Actinomyces naeslundii, and Streptococcus mutans were all susceptible to chlorhexidine individually, with S. mutans dis...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720020901
更新日期：1993-02-01 00:00:00
abstract：:Local anesthetic agents may be classified according to their intrinsic anesthetic potency and duration of activity. Procaine and chloroprocaine are relatively weak, short-acting drugs. Lidocaine, mepivacaine, and prilocaine represent agents of intermediate potency and duration of action. Tetracaine, bupivacaine, and e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600080903
更新日期：1981-08-01 00:00:00
abstract：:Ten dental casting alloys were tested for alloy-element release into cell-culture medium, and this release was related to alloy composition, alloy microstructure, and alloy cytotoxicity (previously determined). Cell-culture medium was analyzed for alloy elements by flame atomic absorption. Concentrations of elements i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700060301
更新日期：1991-06-01 00:00:00
abstract：:Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515572190
更新日期：2015-04-01 00:00:00
abstract：:In vitro wear data were determined for nine experimental composites and compared with two-year clinical data. The in vitro tests included single-pass wear and two-body abrasion. The in vivo data were obtained between 1978 and 1980 for 54 class 2 posterior composite restorations in 25 patients. Correlations between the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620101801
更新日期：1983-10-01 00:00:00
abstract：:Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a speci...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510382546
更新日期：2011-01-01 00:00:00
abstract：:The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670061401
更新日期：1988-06-01 00:00:00
abstract：:Macrophage colony-stimulating factor (CSF-1) is a key regulatory cytokine for amelogenesis, and ameloblasts synthesize CSF-1. We hypothesized that PDGF stimulates DNA synthesis and regulates CSF-1 in these cells. We determined the effect of PDGF on CSF-1 expression using MEOE-3M ameloblasts as a model. By RT-PCR, MEOE...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700105
更新日期：2008-01-01 00:00:00
abstract：:TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514530164
更新日期：2014-06-01 00:00:00
abstract：:Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301010
更新日期：2004-10-01 00:00:00
abstract：:Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeabilit...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650021001
更新日期：1986-02-01 00:00:00
abstract：:In previous studies, human dental pulp stem cells (hDPSCs) were mainly isolated from adults. In this present study, we characterized hDPSCs isolated from an earlier developmental stage to evaluate the potential usage of these cells for tissue-regenerative therapy. hDPSCs isolated at the crown-completed stage showed a ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700716
更新日期：2008-07-01 00:00:00
abstract：:An adhesive opaque resin for veneering on cast metal was developed with 4-methacryloxyethyl trimellitate anhydride and poly (methyl methacrylate)-coated titanium dioxide prepared by aqueous phase polymerization. The opaque resin was a modified 4-META/MMA-TBB resin. The powder consisted of 20% of the encapsulated mater...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670010501
更新日期：1988-01-01 00:00:00
abstract：:The present study was conducted to investigate the role of proteolysis by matrix metalloproteinase 20 (MMP20) in regulating the initial formation of the enamel mineral structure during the secretory stage of amelogenesis, utilizing Mmp20-null mice that lack this essential protease. Ultrathin sagittal sections of maxil...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518823537
更新日期：2019-04-01 00:00:00
abstract：:Hemifacial microsomia (HFM) is a congenital disorder marked by facial asymmetry. Whether facial asymmetry accounts for asymmetrical dental development is unknown. There are few data on dental development relative to mandibular development or severity of HFM, or on development over time. We hypothesized that when mandi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510378425
更新日期：2010-12-01 00:00:00
abstract：:Autosomal dominant mutations in PTH1R segregate with primary failure of eruption (PFE), marked by clinical eruption failure of adult teeth without mechanical obstruction. While the diagnosis of PFE conveys a poor dental prognosis, there are no reports of PFE patients who carry PTH1R mutations and exhibit any other ske...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513513588
更新日期：2014-02-01 00:00:00
abstract：:The goal of the present investigation was to study whether periodic use of fluoride-gel treatments resulted in an increased prevalence of dental fluorosis. 269 children, from 14 to 16 years of age, who had received semi-annual or quarterly fluoride-gel treatments were examined for possible fluoride-induced enamel chan...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640081101
更新日期：1985-08-01 00:00:00
abstract：:The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501205
更新日期：2006-12-01 00:00:00
abstract：:Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670080401
更新日期：1988-08-01 00:00:00
abstract：:The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515593055
更新日期：2015-10-01 00:00:00
abstract：:To identify salivary biomarkers of periodontal diseases, we used plaque-resistant and -susceptible rats as animal models. The levels of salivary cystatin S in saliva, salivary glands, and gingiva were tested in Nembutal-anesthetized young and adult plaque-resistant and -susceptible rats of both sexes with and without ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770110801
更新日期：1998-11-01 00:00:00
abstract：:Early-onset periodontitis (EOP) is considered to have a genetic basis which has not been clearly defined. Genetic polymorphisms of the vitamin D receptor (VDR-B-b) and the immunoglobulin-Fc-gamma receptor IIIb (FcgammaRIIIb-NA1-NA2) are associated with bone metabolism and infectious diseases, respectively. The purpose...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800120501
更新日期：2001-12-01 00:00:00
abstract：:Synovial hyperplasia is a feature of degenerative temporomandibular joint (TMJ) disease. However, the mechanism by which hyperplasia progresses in the TMJ is unknown. Based on the hypothesis that the oxidative stress generated by mechanical loading causes degenerative changes in the TMJ synovium, we investigated the g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300807
更新日期：2004-08-01 00:00:00
abstract：:A series of in vitro studies have been performed to study the release of tin and fluoride from an experimental prophylactic cup and the influence of this release on the fluoride content of enamel. It has been found that the release of fluoride from the prophy cup during a simulated prophylaxis results in a significant...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550030801
更新日期：1976-05-01 00:00:00
abstract：:Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the caries process. To determine whether they differ in their responses to oral pathogens, we performed a systematic comparative analysis o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700304
更新日期：2008-03-01 00:00:00
abstract：:Damage to the dentin matrix investigates the proliferation and mobilization of dental progenitor cells to the injury site, the mechanisms of which are not defined. EphB receptors and ephrin-B ligands expressed within the perivascular niche of dental pulp have been implicated following tooth injury. We propose that ele...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509342363
更新日期：2009-09-01 00:00:00
abstract：:Dental epithelial progenitor cells differentiate into various cell types during development of tooth germs. To study this mechanism, we produced immortalized dental epithelial progenitor cells derived from the cervical-loop epithelium of a rat lower incisor. The expression patterns of cytokeratin 14, nerve growth fact...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300209
更新日期：2004-02-01 00:00:00
abstract：:There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625907
更新日期：2016-04-01 00:00:00
abstract：:The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diami...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910508400907
更新日期：2005-09-01 00:00:00
