Abstract:
:Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome that possesses all of the cardinal features of periodontal disease, including epithelial proliferation and apical migration, loss of attachment, and destruction of cementum and alveolar bone. In this model, bacterial colonization and infection were not required, since levels of periodontal bacteria were equivalent in transgenic and wild-type mice, and continuous treatment with antibiotics from birth did not ameliorate the disease. Our findings therefore indicate that elevated levels of IL-1alpha in the oral micro-environment can mediate all of the clinical features of periodontal disease.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Dayan S,Stashenko P,Niederman R,Kupper TSdoi
10.1177/154405910408301010keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
786-90issue
10eissn
0022-0345issn
1544-0591pii
83/10/786journal_volume
83pub_type
杂志文章abstract::Previous studies showed that residual compressive stresses induced by thermal tempering retarded the growth of surface cracks in bilayered porcelain disks. The objectives of the present study were: (1) to determine whether thermal tempering by air blasting reduces the length of cracks induced by microhardness indentat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750020301
更新日期:1996-02-01 00:00:00
abstract::Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types of human cells are not easily accessible to minimally invasive procedures. Here we evaluated dental pulp cells (DPCs) as an optimal source of iPS cells, since they are easily obtained ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510366846
更新日期:2010-08-01 00:00:00
abstract::Incisors of Mg-deficient rats showed a marked inhibition of eruption and a decrease in mitoses of apical tissues. Cortisone administration resulted in some increase in eruption rate and cell division though these remained below the values of Mg-supplemented controls. An improvement in gross condition and a less severe...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560122901
更新日期:1977-12-01 00:00:00
abstract::The adsorption isotherms of benzoic acid on synthetic hydroxyapatite (containing about 1.5 monolayers of physisorbed water) were studied from ethanol, dimethylsulfoxide, p-dioxane, methylene chloride, and benzene to discern the role of solvent in the process. The adsorption is reversible from the first three solvents ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650051601
更新日期:1986-05-01 00:00:00
abstract::It has often been hypothesized that a large tongue leads to an enlargement of the mandible and therefore contributes to the development of mandibular prognathism. We examined (1) whether the tongue volume in human subjects with mandibular prognathism was larger than that in subjects with good occlusion and (2) whether...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750120701
更新日期:1996-12-01 00:00:00
abstract::The purpose of this investigation was to determine whether chlorhexidine combined with copper would exert a synergistic, growth-inhibitory effect against selected oral bacteria. Actinomyces viscosus, Actinomyces naeslundii, and Streptococcus mutans were all susceptible to chlorhexidine individually, with S. mutans dis...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720020901
更新日期:1993-02-01 00:00:00
abstract::Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain pre...
journal_title:Journal of dental research
pub_type: 传,历史文章,杂志文章
doi:10.1177/0022034510366677
更新日期:2010-07-01 00:00:00
abstract::Protease-activated receptors (PARs) are G protein-coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 and PAR-2 gene expres...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517719415
更新日期:2017-12-01 00:00:00
abstract::Selected area reflection electron diffraction has been used to determine the phases present in the reaction zones surrounding the Ag-Cu eutectic dispersant in Dispersalloy amalgam. The experiments were carried out on two kinds of specimens, (1) Dispersalloy amalgam and (2) Dispersalloy amalgam using 30, 50, 75, and 10...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560090101
更新日期:1977-09-01 00:00:00
abstract::Periodontitis is a chronic inflammatory disease affecting oral tissues. The continuous, high production of cytokines by host cells triggered by periodontopathogens is thought to be responsible for the destruction of tooth-supporting tissues. Macrophages play a critical role in this host inflammatory response to period...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500306
更新日期:2006-03-01 00:00:00
abstract::The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory bi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512470691
更新日期:2013-02-01 00:00:00
abstract:UNLABELLED:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We have recently reported that MS induces predominantly C-C chemokine li...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512467803
更新日期:2013-01-01 00:00:00
abstract::During porcelainization the non-preoxidized alloy develops a Be-rich reaction zone in the interface which separates a Be-depleted alloy from a Li and (to a lesser extent Na) depleted region of the ceramic. Thus, Be diffuses to the interface through the alloy Be degrees leads to Be++ + 2 e- occurs at the interface; som...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570021501
更新日期:1978-02-01 00:00:00
abstract::We previously demonstrated that an anti-caries DNA vaccine intranasally administered with recombinant flagellin protein as a mucosal adjuvant enhanced salivary IgA response and conferred better protection against caries. However, the relatively weak immunogenicity of DNA vaccines and the necessity for a large quantity...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512457684
更新日期:2012-10-01 00:00:00
abstract::The gingival microbiota in beagle dogs was investigated during a period of 42 days after the placement of continuous wire and arch bar splints. The splints were found to induce an increase in helicoidal-shaped micro-organisms and black-pigmented Bacteroides. Two different asaccharolytic Bacteroides types were isolated...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630110601
更新日期:1984-11-01 00:00:00
abstract::The mechanism of formation of nodular material on the surface of a Pd-Ag-based alloy for porcelain during pre-porcelainization heat treatment was investigated using scanning electron microscopy, x-ray diffraction, quantitative metallography, and Auger electron spectroscopy. The nodules were found to form by a Nabarro-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620121201
更新日期:1983-12-01 00:00:00
abstract::Strength and durability of the dentin-acrylic resin joint cemented with 2-cyanoacrylate esters were studied. Maximum adhesion is obtained with isobutyl 2-cyanoacrylate after 1% acid pretreatment of the dentin. Hydrolytic stability is somewhat improved by addition of polymer to the adhesive or coating around the joint....
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580090901
更新日期:1979-09-01 00:00:00
abstract::As an approach for improving the outcome and predictability of periodontal regenerative therapies, we have focused on determining the responses of cells within the local environment to putative regenerative factors. This study examined the effects of bone morphogenetic protein-2 (BMP-2) on murine cementoblasts in vitr...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200106
更新日期:2003-01-01 00:00:00
abstract::Insulin resistance is one of the critical pathogeneses of type 2 diabetes mellitus (T2DM). Elevated levels of plasma branched-chain amino acids (BCAAs) are associated with insulin resistance. Recent studies have demonstrated the role of Porphyromonas gingivalis in the development of insulin resistance. However, the me...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520911037
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abstract::Silver cations generated by passing low intensity direct current through pure silver electrodes were found to be sufficiently antibacterial to cause sterilization of samples of infected dentin. The optimal procedure involved a 5 microA current applied for 20 minutes with the anode then left in contact with the sample....
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570091901
更新日期:1978-09-01 00:00:00
abstract::A previously reported technique for staining areas of degradation in dental composite restorations was evaluated in 51 removed restorations. The staining reagent was silver nitrate, which penetrated the degraded subsurface as ionic silver and was subsequently developed into colored deposits of metallic silver. Several...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700031201
更新日期:1991-03-01 00:00:00
abstract::For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and synthesize data of comparative dental restorative trials. A systematic review was performed. Randomized controlled trials published between 2005 and 2015 were inc...
journal_title:Journal of dental research
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0022034516631285
更新日期:2016-06-01 00:00:00
abstract::Diet is recognized as one of the most important factors affecting the equilibrium of the oral bacterial flora. Studies related to dental caries development have focused mainly on the effect of carbohydrates. In the present work, using swabbing coupled with an immuno-colony-blot assay, we followed the indigenous oral b...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690030801
更新日期:1990-03-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain. The objective of this study was to elucidate the mechanisms whereby CGRP mediated trigeminal neuron-glia crosstalk in modulating orofacial p...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520950296
更新日期:2021-01-01 00:00:00
abstract::Eighteen different Streptococcus strains including S mutans, sanguis, mitis, salivarius, bovis, and 2F2, were assayed for their relative adsorption to synthetic hydroxyapatite and for quantities of lactic acid produced while in the adsorbed state. The results indicated that all S mutans and some S sanguis have an enha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560101401
更新日期:1977-10-01 00:00:00
abstract::The histopathologic status of gingival tissue was assessed according to the criteria of Page and Schroeder.(5) Rhodamine-labeled bacteria were used to assess the antigenic specificity of plasma cells in the tissue. Examination of tissue sections revealed that 31.6% of plasma cells in the advanced lesions bound the lab...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034580059S213
更新日期:1980-11-01 00:00:00
abstract::Deciduous teeth were collected from children who received professional prophylaxis with an acidulated phosphate-fluoride (APF) or placebo paste and were analyzed to determine fluoride uptake. Enamel fluoride level was increased by the APF paste approximately 300 ppm at a depth of 2.5 micrometers during the first month...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550064901
更新日期:1976-11-01 00:00:00
abstract::Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic de...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034511421926
更新日期:2011-11-01 00:00:00
abstract::An intra-oral model system has been developed which uses a single-section technique for before-and-after measurements on the same tissue. This model allows for placement of sections of enamel at both buccal and approximal sites. These sections may be sound or possess white-spot lesions. This allows for the evaluation ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660091401
更新日期:1987-09-01 00:00:00
abstract::Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment. Prostaglandin E1 or E2 solutions injected in gingiva lying near the upper first molar caused the appearance of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590101301
更新日期:1980-10-01 00:00:00