Hyperocclusion stimulates osteoclastogenesis via CCL2 expression.

abstract：:microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...

journal_title：Journal of dental research

authors： Chen N,Sui BD,Hu CH,Cao J,Zheng CX,Hou R,Yang ZK,Zhao P,Chen Q,Yang QJ,Jin Y,Jin F

更新日期：2016-11-01 00:00:00

abstract：:Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...

journal_title：Journal of dental research

authors： Martins MD,Jiao Y,Larsson L,Almeida LO,Garaicoa-Pazmino C,Le JM,Squarize CH,Inohara N,Giannobile WV,Castilho RM

更新日期：2016-02-01 00:00:00

abstract：:Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...

journal_title：Journal of dental research

authors： Izutsu KT,Schubert MM,Truelove EL,Johnson DE

更新日期：1987-02-01 00:00:00

abstract：:Protease-activated receptors (PARs) are G protein-coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 and PAR-2 gene expres...

journal_title：Journal of dental research

authors： Alvarez MMP,Moura GE,Machado MFM,Viana GM,de Souza Costa CA,Tjäderhane L,Nader HB,Tersariol ILS,Nascimento FD

更新日期：2017-12-01 00:00:00

abstract：:The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...

journal_title：Journal of dental research

authors： van Kampen FM,van der Bilt A,Cune MS,Bosman F

更新日期：2002-03-01 00:00:00

abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...

journal_title：Journal of dental research

authors： Qin W,Wang C,Jiang C,Sun J,Yu C,Jiao T

更新日期：2020-07-01 00:00:00

abstract：:Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering. Here, we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional odontoblasts and endot...

journal_title：Journal of dental research

authors： Sakai VT,Zhang Z,Dong Z,Neiva KG,Machado MA,Shi S,Santos CF,Nör JE

更新日期：2010-08-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor involved in the sensing of RNA viruses and the initiation of antiviral responses. Fusobacterium nucleatum, a Gram-negative anaerobic bacterium associated with periodontal disease, is capable of invading cells. We hypothesized that F. nu...

journal_title：Journal of dental research

authors： Lee P,Tan KS

更新日期：2014-02-01 00:00:00

abstract：:Two copper-free amalgams expanded excessively after storage in air at 60 degrees C for about five yr. One expanded significantly at 37 degrees C and slightly at 23 degrees C. High silver content, absence of copper, and presence of small amounts of zinc, or all three, seemed to promote very high expansions at 60 degree...

journal_title：Journal of dental research

authors： Paffenbarger GC,Rupp NW,Patel PR

更新日期：1982-06-01 00:00:00

abstract：:To identify salivary biomarkers of periodontal diseases, we used plaque-resistant and -susceptible rats as animal models. The levels of salivary cystatin S in saliva, salivary glands, and gingiva were tested in Nembutal-anesthetized young and adult plaque-resistant and -susceptible rats of both sexes with and without ...

journal_title：Journal of dental research

authors： Abe K,Okina A,Yano T,Gao C,Ohmori H,Ishibashi K,Nishiura T,Letić-Gavrilović A

更新日期：1998-11-01 00:00:00

abstract：:Data from the actual private practices of two dentists were compared with respective data from the participation of the same two dentists in a laboratory model of private practice conducted in the University of North Carolina Dental Research Center. The findings show that a laboratory model can be established which ac...

journal_title：Journal of dental research

authors： Chadwick DG

更新日期：1975-05-01 00:00:00

abstract：:Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...

journal_title：Journal of dental research

authors： Kirkham J,Robinson C,Strafford SM,Shore RC,Bonass WA,Brookes SJ,Wright JT

更新日期：1996-09-01 00:00:00

abstract：:The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...

journal_title：Journal of dental research

authors： Murasaki K,Watanabe M,Takahashi K,Ito G,Suekawa Y,Inubushi T,Hirose N,Uchida T,Tanne K

更新日期：2013-03-01 00:00:00

abstract：:Recent studies have shown that the extent of hydrolysis by plaque of the trypsin substrate, N-benzoyl-DL-arginine-2-naphthylamide (BANA), correlates with the numbers and proportions of spirochetes in subgingival plaque samples, and appears to be an indicator of clinical disease. In this study, BANA hydrolysis by subgi...

journal_title：Journal of dental research

authors： Schmidt EF,Bretz WA,Hutchinson RA,Loesche WJ

更新日期：1988-12-01 00:00:00

abstract：:Urinary catecholamines have been used to measure emotionally stressful states which may affect the development of dental caries. This study investigates the hypothesis that children with and without dental caries do not differ significantly in the mean values of urinary catecholamines such as epinephrine, norepinephri...

journal_title：Journal of dental research

authors： Vanderas AP,Manetas C,Papagiannoulis L

更新日期：1995-10-01 00:00:00

abstract：:Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...

journal_title：Journal of dental research

authors： Cowman RA,Schaefer SJ,Fitzgerald RJ,Rosner D,Shklair IL,Walter RG

更新日期：1979-10-01 00:00:00

abstract：:We have investigated the role of the activation of nuclear poly(ADP-ribose) polymerase (PARP) enzyme, a mediator of downstream nitric oxide toxicity, using a combined approach of pharmacological inhibition and genetic disruption in a ligature-induced-periodontitis model in rats and mice. Immunohistochemical analysis r...

journal_title：Journal of dental research

authors： Lohinai Z,Mabley JG,Fehér E,Marton A,Komjáti K,Szabó C

更新日期：2003-12-01 00:00:00

abstract：:Limited cure depth is a drawback of light-activated composites. We hypothesize that curing light transmission and cure depth are influenced by monomer reactivity and filler/resin refractive index mismatch. Light transmission throughout cure was recorded for composites based on strontium (refractive index 1.51) or bari...

journal_title：Journal of dental research

authors： Shortall AC,Palin WM,Burtscher P

更新日期：2008-01-01 00:00:00

abstract：:In previous studies, light-cured glass-ionomer cements have been shown to evoke cytotoxic reactions. It was the purpose of this investigation (a) to determine the nature of the ingredients released into an aqueous medium from 2 light-cured glass-ionomer cements (GICs) and 3 compomers; (b) to evaluate the cytotoxicity ...

journal_title：Journal of dental research

authors： Geurtsen W,Spahl W,Leyhausen G

更新日期：1998-12-01 00:00:00

abstract：:Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...

journal_title：Journal of dental research

authors： Curzon ME

更新日期：1985-12-01 00:00:00

abstract：:Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...

journal_title：Journal of dental research

authors： Townsend G,Richards L,Hughes T

更新日期：2003-05-01 00:00:00

abstract：:Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, ...

journal_title：Journal of dental research

authors： Werneck RI,Lázaro FP,Cobat A,Grant AV,Xavier MB,Abel L,Alcaïs A,Trevilatto PC,Mira MT

更新日期：2011-06-01 00:00:00

abstract：:PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...

journal_title：Journal of dental research

authors： Mitsui SN,Yasue A,Masuda K,Watanabe K,Horiuchi S,Imoto I,Tanaka E

更新日期：2014-03-01 00:00:00

abstract：:In two separate experiments, none of the 14 subunits examined consistently ranked dentifrices similarly to the ranking obtained when the individual rat was used as the experimental unit. Arbitrarily dividing the rat into subunits and then comparing results among these subunits may lead to false conclusions since the r...

journal_title：Journal of dental research

authors： Briner WW

更新日期：1976-05-01 00:00:00

abstract：:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...

journal_title：Journal of dental research

authors： Hagiwara M,Kurita-Ochiai T,Kobayashi R,Hashizume-Takizawa T,Yamazaki K,Yamamoto M

更新日期：2014-04-01 00:00:00

abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...

journal_title：Journal of dental research

authors： Crowe DL,Milo GE,Shuler CF

更新日期：1999-06-01 00:00:00

abstract：:The human mandibular condyle has a parasagittal plate-like trabecular structure. We tested the hypothesis that this structure reflects the mechanical loading of the condyle. We developed a finite element model of the condyle to analyze the strains occurring during static compressive loading. The principal strains in t...

journal_title：Journal of dental research

authors： van Ruijven LJ,Giesen EB,van Eijden TM

更新日期：2002-10-01 00:00:00

abstract：:Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...

journal_title：Journal of dental research

authors： Foster BL,Sheen CR,Hatch NE,Liu J,Cory E,Narisawa S,Kiffer-Moreira T,Sah RL,Whyte MP,Somerman MJ,Millán JL

更新日期：2015-05-01 00:00:00

abstract：:A quantitative microprobe analysis was conducted on three commercial amalgams to determine the nature of the phases present. The presence of tin in the Ag-Hg phase (gamma1) was confirmed and Cu-3Sn was found in the original alloy particles. In the dispersant amalgam studied, little Sn-Hg phase (gamma-2) was found and ...

journal_title：Journal of dental research

authors： Mahler DB,Adey JD,Van Eysden J

更新日期：1975-03-01 00:00:00

abstract：:In this study, we sought to determine the association between tooth agenesis and DNA sequence variation in the genes MSX1 and PAX9 in an ethnically diverse human population. Since cleft lip/palate is also associated with both tooth agenesis and the gene TGFA, we included TGFA in the analysis as well. Cheek swab sample...

journal_title：Journal of dental research

authors： Vieira AR,Meira R,Modesto A,Murray JC

更新日期：2004-09-01 00:00:00