Abstract：
:In this study, we sought to determine the association between tooth agenesis and DNA sequence variation in the genes MSX1 and PAX9 in an ethnically diverse human population. Since cleft lip/palate is also associated with both tooth agenesis and the gene TGFA, we included TGFA in the analysis as well. Cheek swab samples were obtained for DNA analysis from 116 case/parent trios. Probands had at least one developmentally missing tooth, excluding third molars. Genotyping was performed by single-strand conformational polymorphism or kinetic polymerase chain-reaction assays. Transmission distortion of the marker alleles and DNA sequence analysis was performed. Results showed that tooth agenesis is associated with markers of the genes MSX1 and TGFA. No mutations were found in MSX1 or PAX9 coding regions. There were statistically significant data suggesting that MSX1 interacts with PAX9. These findings suggest that MSX1, PAX9, and TGFA play a role in isolated dental agenesis.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Vieira AR,Meira R,Modesto A,Murray JCdoi
10.1177/154405910408300913keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
723-7issue
9eissn
0022-0345issn
1544-0591pii
83/9/723journal_volume
83pub_type
杂志文章abstract：:The fluid in and gingival tissue lining periodontal pockets were collected from male patients undergoing periodontal therapy. The collagenolytic activity of the crevicular fluid, and the ability of the gingiva in culture to degrade (a) an exogenous collagen substrate, and (b) endogenous collagen newly synthesized and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580111601
更新日期：1979-11-01 00:00:00
abstract：:A new type of hydraulic cement has been developed. This cement consists of a mixture of cement powder and setting agent powder and therefore has only to be kneaded with a little amount of water when being used. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580050601
更新日期：1979-05-01 00:00:00
abstract：:The microstructure of the set glass-polyalkenoate cement has not been undertaken beyond a study where an Electron Probe Micro Analyser was used. The purpose of this investigation was to determine the ion distribution in matrix parts of the set cement by means of Secondary Ion Mass Spectrometry (SIMS). Among the techni...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780011301
更新日期：1999-01-01 00:00:00
abstract：:The objectives of the study were to describe the oral health status and treatment needs of the 5- to 6-year-old and 12-year-old children in Southern China; to describe the patterns of oral health behaviors, knowledge, and attitudes among the 12-year-olds; and to assess the effects of socio-behavioral factors on the 12...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800051501
更新日期：2001-05-01 00:00:00
abstract：:Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515573273
更新日期：2015-05-01 00:00:00
abstract：:Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300403
更新日期：2004-04-01 00:00:00
abstract：:For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and synthesize data of comparative dental restorative trials. A systematic review was performed. Randomized controlled trials published between 2005 and 2015 were inc...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析,评审
doi：10.1177/0022034516631285
更新日期：2016-06-01 00:00:00
abstract：:Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis usin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511423394
更新日期：2011-12-01 00:00:00
abstract：:Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590071001
更新日期：1980-07-01 00:00:00
abstract：:In a three-year study of 145 adolescent males in a boarding school in Wisconsin, there were no statistically significant differences in dental caries experience between a group consuming phosphates added to pre-sweetened and non-presweetened ready-to-eat cereals, and the control group, or between cereal eaters and non...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345790580090201
更新日期：1979-09-01 00:00:00
abstract：:Improved mechanical properties of resin composites have been reported to be a consequence of the addition of aldehyde to the resins. The objective of the present study was to examine whether this improvement could be attributed to an increased degree of conversion of double bonds. For this purpose, propanal was added ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730101101
更新日期：1994-10-01 00:00:00
abstract：UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512463241
更新日期：2013-01-01 00:00:00
abstract：:The main purpose of this paper is to review the various methods used for evaluation of fluoride retention in saliva, plaque, and enamel following application of topical anti-caries treatments such as F dentifrices and F mouthwashes. Such methods monitor delivery of fluoride to the site of action, the mouth, and so can...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/002203459207100S29
更新日期：1992-04-01 00:00:00
abstract：:Joining a brittle veneer to a strong ceramic core with an adhesive offers potential benefits over current fabrication methods for all-ceramic crowns. We tested the hypothesis that such joining can withstand subsurface radial cracking in the veneer, from enhanced flexure in occlusal loading, as well as in the core. Cri...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700408
更新日期：2008-04-01 00:00:00
abstract：:Using glycoproteins and milk oligosaccharides as substrate acceptors, we demonstrated at least two fucosyltransferases in human parotid saliva. One enzyme transferred L-fucose from GDP-fucose to the C-3 position of N-acetylglucosamine or glucose residue of oligosaccharide chains, and the other transferred to the C-4 p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620070701
更新日期：1983-07-01 00:00:00
abstract：:In this study, we analyzed the influence of prosthetic abutment height on marginal bone loss (MBL) around implants in the posterior maxilla. In this retrospective cohort study, the radiographically determined MBL was related to the height of the abutments of internal conical connection implants at 6 and 18 months post...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513519800
更新日期：2014-07-01 00:00:00
abstract：:The discovery of the phenomenon "osseointegration," or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519853574
更新日期：2019-11-01 00:00:00
abstract：:Secondary palatogenesis occurs when the bilateral palatal shelves (PS), arising from maxillary prominences, fuse at the midline, forming the hard and soft palate. This embryonic phenomenon involves a complex array of morphogenetic events that require coordinated proliferation, apoptosis, migration, and adhesion in the...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517726284
更新日期：2017-10-01 00:00:00
abstract：:The following five outlines are the results to date of the Workshop held in Rockville, Maryland, in January, 1990. The topics considered in these outlines are: (1) validation of immunological and/or nucleic acid identification probes, (2) cross-calibration of methods and/or laboratories for multi-laboratory cooperativ...
journal_title：Journal of dental research
pub_type： 指南,杂志文章
doi：10.1177/00220345910700031401
更新日期：1991-03-01 00:00:00
abstract：:Synovial hyperplasia is a feature of degenerative temporomandibular joint (TMJ) disease. However, the mechanism by which hyperplasia progresses in the TMJ is unknown. Based on the hypothesis that the oxidative stress generated by mechanical loading causes degenerative changes in the TMJ synovium, we investigated the g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300807
更新日期：2004-08-01 00:00:00
abstract：:Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513495239
更新日期：2013-08-01 00:00:00
abstract：:Relative glycogen synthetic abilities of resting cells of fresh clinical isolates of Actinomyces viscosus and Actinomyces naeslundii originating from dental plaque samples over root surface caries lesions and non-carious sites were studied under anaerobic conditions at a constant pH of 7.0, with U-(14C)-glucose used a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650060701
更新日期：1986-06-01 00:00:00
abstract：:It is claimed that dental fluorosis in both deciduous and permanent teeth is increasing in fluoridated and non-fluoridated communities. What is unclear is whether fluoride-induced enamel opacities in the deciduous dentition are associated with the subsequent appearance of enamel defects in the permanent dentition. The...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750040301
更新日期：1996-04-01 00:00:00
abstract：:Alendronate (ALN) is an antiresorptive agent widely used for the treatment of osteoporosis. Its suppressive effect on osteoclasts has been extensively studied. However, the effect of ALN on bone formation is not as clear as its effect on resorption. The objective was to determine the effect of short-term ALN on bone f...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515592867
更新日期：2015-09-01 00:00:00
abstract：:Lingual amylase and lingual lipase, two digestive enzymes that are secreted from lingual serous glands (von Ebner's), were simultaneously purified from rat lingual serous glands with hydrophobic chromatography used as the final step. This method, previously developed for the purification of lingual lipase, includes ho...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680020801
更新日期：1989-02-01 00:00:00
abstract：:Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600021501
更新日期：1981-02-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:In mineralizing hamster molars, the influence of several inhibitors on p-NPP-ase has been demonstrated, and compared with their effect on PPi-ase, known to belong to the same enzyme. Whereas the latter activity is much more physiological, p-NPP is a better substrate to distinguish between the effects of bivalent catio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560102701
更新日期：1977-10-01 00:00:00
abstract：:To identify salivary biomarkers of periodontal diseases, we used plaque-resistant and -susceptible rats as animal models. The levels of salivary cystatin S in saliva, salivary glands, and gingiva were tested in Nembutal-anesthetized young and adult plaque-resistant and -susceptible rats of both sexes with and without ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770110801
更新日期：1998-11-01 00:00:00
abstract：:Laser-Raman spectra of synthetic apatites containing from zero to 12.4 wt% carbonate ions and enamel apatite are reported. Special attention is paid to the correlation between the intensities of the carbonate, phosphate, and hydroxyl modes and the carbonate content in the apatites. The data presented here indicate tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600031601
更新日期：1981-03-01 00:00:00
