Abstract：
:Secondary palatogenesis occurs when the bilateral palatal shelves (PS), arising from maxillary prominences, fuse at the midline, forming the hard and soft palate. This embryonic phenomenon involves a complex array of morphogenetic events that require coordinated proliferation, apoptosis, migration, and adhesion in the PS epithelia and underlying mesenchyme. When the delicate process of craniofacial morphogenesis is disrupted, the result is orofacial clefting, including cleft lip and cleft palate (CL/P). Through human genetic and animal studies, there are now hundreds of known genetic alternations associated with orofacial clefts; so, it is not surprising that CL/P is among the most common of all birth defects. In recent years, in vitro cell-based assays, ex vivo palate cultures, and genetically engineered animal models have advanced our understanding of the developmental and cell biological pathways that contribute to palate closure. This is particularly true for the areas of PS patterning and growth as well as medial epithelial seam dissolution during palatal fusion. Here, we focus on epithelial cell-cell adhesion, a critical but understudied process in secondary palatogenesis, and provide a review of the available tools and mouse models to better understand this phenomenon.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Lough KJ,Byrd KM,Spitzer DC,Williams SEdoi
10.1177/0022034517726284subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1210-1220issue
11eissn
0022-0345issn
1544-0591journal_volume
96pub_type
杂志文章,评审abstract：:A double-blind randomized clinical trial was performed in 6- to 7-yr-old schoolchildren to evaluate, in a 30-mo period, whether the caries increment on the distal surface of the second primary molars adjacent to permanent first molars sealed with fluoride release compounds would be lower with respect to those adjacent...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034514535808
更新日期：2014-07-01 00:00:00
abstract：:Stereologic studies of trabecular architecture suggest that the pig mandibular condyle is strongest when loaded supero-inferiorly, and that stress is concentrated in the antero-inferior region (Teng and Herring, 1995). To test these hypotheses, we investigated the uni-axial mechanical properties of 22 pig mandibular c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750110501
更新日期：1996-11-01 00:00:00
abstract：:Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650071601
更新日期：1986-07-01 00:00:00
abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage pain and inflammatory disorders. We hypothesized that gingival fibroblasts actively accumulate NSAIDs and enhance their levels in gingival connective tissue. Using fluorescence to monitor NSAID transport, we demonstrated that cultured gingival fibroblas...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500511
更新日期：2006-05-01 00:00:00
abstract：:Although dental amalgam is used frequently under artificial crowns for restoration of severely damaged teeth, there is little information available on the bond between luting cements and this alloy. This study was designed for determination of the strength of the bond between a dental amalgam alloy and three crown-lut...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680111501
更新日期：1989-11-01 00:00:00
abstract：:This study demonstrated a correlation between silicon x-ray counts and area fractions of adherent porcelain as determined by point-counting. This correlation has allowed a method to be devised for measuring area fractions of porcelain adherent to porcelain-fused-to-metal (PFM) fracture surfaces. The described method, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620081801
更新日期：1983-08-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:Investigations of the maturation pattern of rat incisor enamel by quantitative electron microscopy and electron-probe microanalysis indicate that mineralization of rat enamel can be regarded, as in humans, as a regular and progressive process pattern of enamel matrix formation. The species variations that have been pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580024201
更新日期：1979-03-01 00:00:00
abstract：:Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750090901
更新日期：1996-09-01 00:00:00
abstract：:The accumulated posteruptive tooth age was calculated for 212 children with Down's syndrome and 124 of their unaffected sibs. Posteruptive tooth age was shown to vary widely with different morphological permanent tooth types at the same chronological age. Girls in both groups had greater accumulated posteruptive tooth...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540033001
更新日期：1975-05-01 00:00:00
abstract：:Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750070801
更新日期：1996-07-01 00:00:00
abstract：:In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680121101
更新日期：1989-12-01 00:00:00
abstract：:Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301010
更新日期：2004-10-01 00:00:00
abstract：:Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600818
更新日期：2007-08-01 00:00:00
abstract：:Priming with tumor antigens is one of the most important strategies in cancer immunotherapy. To enhance tumor antigenicity, OK-432, a streptococcal preparation, was coupled to squamous cell carcinoma (KLN-205) by means of a 0.2% glutaraldehyde method. The purpose of this study was to investigate whether OK-432-conjuga...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200813
更新日期：2003-08-01 00:00:00
abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520913873
更新日期：2020-07-01 00:00:00
abstract：:The composition of the degradable glasses used in commercial dental glass-ionomer cements determines their leaching behavior and hence the properties of the cement. The objective of the present study was to assess if the composition and leaching in acetic acid solutions are reflected in the x-ray diffraction character...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800081601
更新日期：2001-08-01 00:00:00
abstract：:Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse mo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519885088
更新日期：2020-01-01 00:00:00
abstract：:The ability of human oral bacteria to inhibit Streptococcus mutans was studied under a variety of in vitro conditions using an agar overlay assay. Extensive inherent variability in microbial antagonism by certain organisms was demonstrated. Antagonistic activity was also significantly influenced by changes in the assa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590110501
更新日期：1980-11-01 00:00:00
abstract：:A/Jax mice were injected with 50 muCi of 3H cortisol and 10 mg of cortisone acetate on day 12 of gestation. At various intervals after injection, the maternal liver, placenta, yolk sac, and the fetal jaws were removed and analyzed by thin-layer chromatography in conjunction with oxidative combustion and liquid scintil...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540051101
更新日期：1975-09-01 00:00:00
abstract：:Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570110901
更新日期：1978-11-01 00:00:00
abstract：:Disks of dentin taken from extracted human teeth demonstrated the optical property of the magnification/reduction effect. When images were transmitted from a pulpal-to-occlusal direction, the images were magnified. When the disks were inverted, the images were reduced in size. The images were slightly distorted but cl...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550041601
更新日期：1976-07-01 00:00:00
abstract：:Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a speci...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510382546
更新日期：2011-01-01 00:00:00
abstract：:Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain pre...
journal_title：Journal of dental research
pub_type： 传,历史文章,杂志文章
doi：10.1177/0022034510366677
更新日期：2010-07-01 00:00:00
abstract：:Dental epithelial progenitor cells differentiate into various cell types during development of tooth germs. To study this mechanism, we produced immortalized dental epithelial progenitor cells derived from the cervical-loop epithelium of a rat lower incisor. The expression patterns of cytokeratin 14, nerve growth fact...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300209
更新日期：2004-02-01 00:00:00
abstract：:In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone fo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560031601
更新日期：1977-03-01 00:00:00
abstract：:Stress-relaxation measurements were performed on specimens of radicular human dentin. The relaxation modulus showed a linear dependence on the logarithm of time and the approximation to the logarithmic distribution function of relaxation times was used to predict the behavior of other viscoelastic properties. This exp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540061801
更新日期：1975-11-01 00:00:00
abstract：:This study was undertaken in order to correlate the immune status of persons with various types of immune dysfunctions with the incidence of dental caries. Preliminary data on caries experience and the microbial composition of plaque in these individuals are presented. The findings suggest that persons with immunoglob...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560030201
更新日期：1977-03-01 00:00:00
abstract：:Three dental amalgams were investigated to determine if their abrasion resistance was significantly affected by different packing pressures. Abrasive wear tests were performed on a machine designed to test materials under conditions similar to masticatory function. The results show that the abrasion resistance of the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560060901
更新日期：1977-06-01 00:00:00
abstract：:This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060601
更新日期：1988-06-01 00:00:00
