Abstract:
:Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed that eugenol caused denaturation of cytoplasmic proteins and loss of staining capacity of epithelium, loss of cell boundaries, swelling and cell necrosis. In addition, vesicle formation, edema in the corium, and striated muscle dissolution were observed.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Kozam G,Mantell GMdoi
10.1177/00220345780570110901subject
Has Abstractpub_date
1978-11-01 00:00:00pages
954-7issue
11-12eissn
0022-0345issn
1544-0591journal_volume
57pub_type
杂志文章abstract::Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic diseases. The Gram-negative anaerobe, Porphyromonas gingivalis, is a key periodontal pathogen, and several lines of evidence link the presence of this bacterium in the circulation with vascular disease. The outer membrane...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520943187
更新日期:2020-12-01 00:00:00
abstract::Dental enamel formation is a remarkable example of a biomineralization process. The exact mechanisms involved in this process remain partly obscure. Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta. Mutational analyses within studied families have s...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/154405910508401206
更新日期:2005-12-01 00:00:00
abstract::Priming with tumor antigens is one of the most important strategies in cancer immunotherapy. To enhance tumor antigenicity, OK-432, a streptococcal preparation, was coupled to squamous cell carcinoma (KLN-205) by means of a 0.2% glutaraldehyde method. The purpose of this study was to investigate whether OK-432-conjuga...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200813
更新日期:2003-08-01 00:00:00
abstract::A detailed understanding of the complexity of root canal systems is imperative to ensure successful root canal preparation. The aim of this study was to evaluate the potential and accuracy of a three-dimensional, non-destructive technique for detailing root canal geometry by means of high-resolution tomography. The an...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790060901
更新日期:2000-06-01 00:00:00
abstract::Early childhood caries (ECC) is a chronic disease affecting the oral health of children globally. This disease is multifactorial, but a primary factor is cariogenic microorganisms such as Streptococcus mutans. Biosynthetic gene clusters (BGCs) encode small molecules with diverse biological activities that influence th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520914519
更新日期:2020-07-01 00:00:00
abstract::Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740071101
更新日期:1995-07-01 00:00:00
abstract::Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514523783
更新日期:2014-04-01 00:00:00
abstract::In periodontal surgery, healing after guided tissue regeneration (GTR) may be explained by differences in functional activities of gingival and periodontal ligament fibroblasts (GF and PDLF). Several studies in vitro have supported this hypothesis, but much remains to be defined. In the present work, gingival and peri...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750030601
更新日期:1996-03-01 00:00:00
abstract::Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690050901
更新日期:1990-05-01 00:00:00
abstract::In previous studies, human dental pulp stem cells (hDPSCs) were mainly isolated from adults. In this present study, we characterized hDPSCs isolated from an earlier developmental stage to evaluate the potential usage of these cells for tissue-regenerative therapy. hDPSCs isolated at the crown-completed stage showed a ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700716
更新日期:2008-07-01 00:00:00
abstract::The main purpose of this paper is to review the various methods used for evaluation of fluoride retention in saliva, plaque, and enamel following application of topical anti-caries treatments such as F dentifrices and F mouthwashes. Such methods monitor delivery of fluoride to the site of action, the mouth, and so can...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/002203459207100S29
更新日期:1992-04-01 00:00:00
abstract::Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) and CKD in 215 Jap...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512455063
更新日期:2012-09-01 00:00:00
abstract::This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550050601
更新日期:1976-09-01 00:00:00
abstract::The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513506443
更新日期:2013-11-01 00:00:00
abstract::Monolayers of feline parotid acinar cells were infected with feline rhinotracheitis herpes virus. Membrane potentials and input resistances were measured before and during infection. Uninfected acinar cells had an average membrane potential of -51 mV and resistances from 6 to 120 mega-ohms; cells infected for more tha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600121001
更新日期:1981-12-01 00:00:00
abstract::Twenty-two adults, considered to have high caries activity, rinsed for one yr with either SnF2 or acidulated NaF mouthrinses. Total colony-forming units and numbers of S. mutans and lactobacilli were estimated from saliva samples. Large reductions were found in the number of recoverable S. mutans in subjects rinsing w...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620081201
更新日期:1983-08-01 00:00:00
abstract::The differential diagnosis of dental wear lesions affects their clinical management. We hypothesized that surface texture parameters can differentiate simulated erosion, abrasion, and erosion-abrasion lesions on human enamel and dentin. This in vitro study comprised 2 parts (both factorial 4 × 2), with 4 lesion types ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516629941
更新日期:2016-05-01 00:00:00
abstract::One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT ...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034513490957
更新日期:2013-07-01 00:00:00
abstract::A gravity sintering fabrication technique has been developed for producing Co-Cr-Mo alloy dental implants having a porous coating on the root portion. This process allows for control of pore structure enabling ingrowth of either bone or fibrous tissue. The microstructure and mechanical properties of these materials ha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560050501
更新日期:1977-05-01 00:00:00
abstract::Cultures of Streptococcus mutans MFe28 (serotype h) were grown with differing extracellular polysaccharide (EPS) content. Biochemical and physicochemical characteristics considered relevant to caries were measured. Acid production parameters measured in a pH-stat were: Vm = 0.76 +/- 0.14 mumol/g/sec (wet weight); appa...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670060101
更新日期:1988-06-01 00:00:00
abstract::Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514523784
更新日期:2014-04-01 00:00:00
abstract::Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515600157
更新日期:2015-11-01 00:00:00
abstract::The impact of osteoporosis on implant treatment is still a matter of debate in the scientific community, as it may possibly lead to higher failure rates. As long-term controlled trials are missing, the aim of this study was to verify the long-term outcome of implants placed in patients with systemic osteoporosis. Post...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034518798804
更新日期:2019-01-01 00:00:00
abstract::Previously, in vitro differentiation of odontoblasts was shown for dental pulp stem cells (DPSCs) transfected with bone morphogenetic protein-2 (Bmp2). For this study, we hypothesized that such cells also show potential for mineralized tissue formation in vivo. DPSCs were transfected with Bmp2 and seeded onto a cerami...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509346258
更新日期:2009-11-01 00:00:00
abstract::Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650071601
更新日期:1986-07-01 00:00:00
abstract::The purpose of this study was to investigate the mechanism of surface layer formation in artificial white spots. Two nondestructive nuclear micro-analysis techniques were employed to analyze windows of human dental enamel at progressive stages of an artificial lesion. Fluoride concentrations were measured to a depth o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620091001
更新日期:1983-09-01 00:00:00
abstract::Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640121201
更新日期:1985-12-01 00:00:00
abstract::In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpr...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034517720403
更新日期:2017-10-01 00:00:00
abstract::PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513519801
更新日期:2014-03-01 00:00:00
abstract::The etiology of dental caries reflects a complex interplay of biochemical, microbial, genetic, social and physical environmental, and health-influencing behavioral factors. This review updates the literature on the efficacy of behavioral approaches to caries prevention for children up to 18 y of age. Included were stu...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034515609034
更新日期:2016-01-01 00:00:00