Abstract:
:Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, with structural equation modeling used to determine the relative contributions of genetic and environmental factors. Maximum mesiodistal crown dimensions of maxillary and mandibular permanent incisors were recorded from dental models of 298 pairs of twins, including 149 monozygous (MZ) and 149 dizygous (DZ) pairs. The analysis revealed that: (i) an adequate fit required additive genetic and unique environmental components; (ii) augmenting the model with non-additive genetic variation did not lead to a significant improvement in fit; (iii) there was evidence of shared environmental influences in the upper central incisors of males; (iv) the additive genetic component constituted a general factor loading on all eight teeth, with group factors loading on antimeric pairs of teeth; (v) unique environmental effects were mostly variable-specific; (vi) most factor loadings on antimeric tooth pairs could be constrained to be equal, indicating a symmetry of genetic and environmental influences between left and right sides; and (vii) estimated heritability of the incisor mesiodistal dimensions varied from 0.81 to 0.91.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Dempsey PJ,Townsend GC,Martin NG,Neale MCdoi
10.1177/00220345950740071101subject
Has Abstractpub_date
1995-07-01 00:00:00pages
1389-98issue
7eissn
0022-0345issn
1544-0591journal_volume
74pub_type
杂志文章abstract::Dietary components rich in polyphenols-for example, tea and red wine-are thought to cause tooth staining. In the present study, hydroxyapatite was used as a model of enamel for study of the influence of salivary proteins on the binding of different polyphenols to hydroxyapatite in vitro. Neither salivary protein pelli...
journal_title:Journal of dental research
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abstract::Apoptosis plays important roles in various stages of organogenesis. In this study, we hypothesized that apoptosis would play an important role in tooth morphogenesis. We examined the role of apoptosis in early tooth development by using a caspase inhibitor, z-VAD-fmk, concomitant with in vitro organ culture and tooth ...
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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pub_type: 历史文章,杂志文章
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abstract::Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...
journal_title:Journal of dental research
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更新日期:1991-12-01 00:00:00
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journal_title:Journal of dental research
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更新日期:1993-12-01 00:00:00
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journal_title:Journal of dental research
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更新日期:1998-12-01 00:00:00
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abstract::Candida colonization of the oral cavity increases in the elderly. A major predisposing condition is denture use, which also increases in the elderly. To test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of ...
journal_title:Journal of dental research
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of dental research
pub_type: 杂志文章
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journal_title:Journal of dental research
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更新日期:1994-06-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00