Abstract：
:Gingival overgrowth tissues have thickened connective tissue stroma, sometimes accompanied by the increased presence of collagen fibers, thickened epithelia, and elongated rete pegs. We have previously shown that expression of CCN2, also known as connective tissue growth factor (CTGF), correlates positively with the degree of gingival fibrosis, and that markers of epithelial to mesenchymal transition (EMT) are characteristic of all drug-induced forms of gingival overgrowth. Here we experimentally evaluate whether increased degradation of the basement membrane and apparent invasion of the underlying stroma by epithelial cells could be observed in human gingival overgrowth tissues. Tissues from 20 different individuals with human gingival overgrowth and 15 non-overgrowth samples were evaluated by histological analyses and by immunohistochemistry assays of basement membrane proteins. The results demonstrate that there are significantly higher numbers of basement membrane discontinuities in overgrowth tissues, sometimes containing epithelial-like cells. Disrupted basal membrane structure in gingival overgrowth tissues is accompanied by a discontinuous collagen type IV expression pattern and decreased laminin 5. These findings provide new additional support for the hypothesis that epithelial plasticity and EMT promote gingival overgrowth, resulting in compromised basal membrane structure and increased interactions between epithelial and connective tissue layers that contribute to fibrotic pathology.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Kantarci A,Nseir Z,Kim YS,Sume SS,Trackman PCdoi
10.1177/0022034511404703subject
Has Abstractpub_date
2011-07-01 00:00:00pages
887-93issue
7eissn
0022-0345issn
1544-0591pii
0022034511404703journal_volume
90pub_type
杂志文章abstract：:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514523784
更新日期：2014-04-01 00:00:00
abstract：:The destabilizing effect of endodontic treatment upon teeth is still controversial. The purpose of this study was to investigate the effects of different steps of endodontic treatments upon the rigidity of teeth. Extracted untreated central maxillary anterior teeth were loaded (3.75 N), and deformations of the root we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500416
更新日期：2006-04-01 00:00:00
abstract：:The gingival microbiota in beagle dogs was investigated during a period of 42 days after the placement of continuous wire and arch bar splints. The splints were found to induce an increase in helicoidal-shaped micro-organisms and black-pigmented Bacteroides. Two different asaccharolytic Bacteroides types were isolated...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630110601
更新日期：1984-11-01 00:00:00
abstract：:The amount of free water in 50 samples of air-dried enamel from permanent and deciduous teeth was measured by the Karl Fischer method. Samples included both contemporary and burial specimens. The mean values obtained showed that free water constituted about 1% of enamel mass. However, the range of individual values va...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/00220345880670051701
更新日期：1988-05-01 00:00:00
abstract：:Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550040401
更新日期：1976-07-01 00:00:00
abstract：:Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300403
更新日期：2004-04-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660031401
更新日期：1987-03-01 00:00:00
abstract：:Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600505
更新日期：2007-05-01 00:00:00
abstract：:Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515602879
更新日期：2015-10-01 00:00:00
abstract：:microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516657043
更新日期：2016-11-01 00:00:00
abstract：:In this study, we first investigated the expressions of Jagged1, Notch2, the receptor activator of nuclear factor-kappa B ligand (RANKL), and interleukin (IL)-6 in areas of root resorption during experimental tooth movement in rats in vivo. We then assessed the effects of compression force (CF) with or without GSI (an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514555364
更新日期：2015-01-01 00:00:00
abstract：:Potassium ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular potassium ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740020301
更新日期：1995-02-01 00:00:00
abstract：:The incorporation of polymerizable cationic monomers has been attempted to generate dental resinous materials with antibacterial activity. This study tested the hypothesis that a dental adhesive containing a cationic monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), would influence biofilm format...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509334499
更新日期：2009-04-01 00:00:00
abstract：:The fatigue crack growth resistance of dentin was characterized as a function of depth from the dentino-enamel junction. Compact tension (CT) specimens were prepared from the crowns of third molars in the deep, middle, and peripheral dentin. The microstructure was quantified in terms of the average tubule dimensions a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511408429
更新日期：2011-08-01 00:00:00
abstract：:The inhibitory activity of 2-phosphono-butane 1,2,4 tricarboxylic acid (PBTA) in the formation of hydroxyapatite (HA) was studied in vitro and in vivo. PBTA, at 4 ppm, inhibited the spontaneous formation of HA in vitro from a supersaturated solution. PBTA, at 2 ppm, completely inhibited the crystal growth of HA; at lo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640011201
更新日期：1985-01-01 00:00:00
abstract：:Insulin resistance is one of the critical pathogeneses of type 2 diabetes mellitus (T2DM). Elevated levels of plasma branched-chain amino acids (BCAAs) are associated with insulin resistance. Recent studies have demonstrated the role of Porphyromonas gingivalis in the development of insulin resistance. However, the me...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520911037
更新日期：2020-07-01 00:00:00
abstract：:The frequency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing the joint's function. The 6 discal attachments have not yet been systematically characterized under tension. Understanding their role in joint function may guide our study of TMJ pathologies, including disc displ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513494817
更新日期：2013-08-01 00:00:00
abstract：:Wavelength-independent Microradiography (WIM), described in this paper, used polychromatic, high-energy (less than or equal to 60 kV) x-rays for determination of mineral concentrations in tooth material non-destructively. This was done with the aid of a reference step-wedge made of 94% aluminum, 6% zinc. The mass atte...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690081501
更新日期：1990-08-01 00:00:00
abstract：:Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740071101
更新日期：1995-07-01 00:00:00
abstract：:In vitro wear data were determined for nine experimental composites and compared with two-year clinical data. The in vitro tests included single-pass wear and two-body abrasion. The in vivo data were obtained between 1978 and 1980 for 54 class 2 posterior composite restorations in 25 patients. Correlations between the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620101801
更新日期：1983-10-01 00:00:00
abstract：:In this study, we sought to determine the association between tooth agenesis and DNA sequence variation in the genes MSX1 and PAX9 in an ethnically diverse human population. Since cleft lip/palate is also associated with both tooth agenesis and the gene TGFA, we included TGFA in the analysis as well. Cheek swab sample...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300913
更新日期：2004-09-01 00:00:00
abstract：:Cellular hypoxia may be a useful indication of tissue distress in the dental pulp that could be used to investigate the early stages of pulpal responses. Tritiated misonidazole (3H-MISO) is a marker which preferentially labels cells with decreased oxygen tension (hypoxia). The experiments reported here were carried ou...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750100801
更新日期：1996-10-01 00:00:00
abstract：:Much research has been devoted to the study of etched enamel, since it is critical to bonding. Currently, there are no precise data regarding the etched-enamel specific surface area. The aim of this study was to characterize, by two different methods, the surface of human dental enamel in vitro after being etched. It ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700607
更新日期：2008-06-01 00:00:00
abstract：:Fungal infections in the oral cavity are mainly caused by C. albicans, but other Candida species are also frequently identified. They are increasing in prevalence, especially in denture-wearers and aging people, and may lead to invasive infections, which have a high mortality rate. Attachment to mucosal tissues and to...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034508329273
更新日期：2009-02-01 00:00:00
abstract：:Evaluation of long-term mechanical behavior of new types of restorations in clinical trials is time-consuming. A partial alternative can be found in experimental fatigue-testing, which simulates accelerated mechanical deterioration. The aim of this study was to determine the feasibility of using fatigue-testing of a c...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345920710050301
更新日期：1992-05-01 00:00:00
abstract：:Tumor progression is often associated with altered glycosylation of the cell-surface proteins and lipids. The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens. The expression of histo-blood-group antigens in normal human tissu...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910508400103
更新日期：2005-01-01 00:00:00
abstract：:Few studies have investigated smoking as a risk factor for root canal treatment. We studied the effect of smoking on the incidence of root canal treatment, controlling for recognized risk factors, in 811 dentate male participants in the VA Dental Longitudinal Study. Participants were not VA patients. Follow-up ranged ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500406
更新日期：2006-04-01 00:00:00
abstract：:Information on the time-dependent release of fluoride from filled resins containing fluoride particles as a function of particle content and solution pH is limited. This study characterized the fluoride ion release from filled resins containing CaF2 particles as a function of filler content and pH. Urethane dimethacry...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400508
更新日期：2005-05-01 00:00:00
abstract：:This study was undertaken in order to correlate the immune status of persons with various types of immune dysfunctions with the incidence of dental caries. Preliminary data on caries experience and the microbial composition of plaque in these individuals are presented. The findings suggest that persons with immunoglob...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560030201
更新日期：1977-03-01 00:00:00
