Abstract：
:Candida colonization of the oral cavity increases in the elderly. A major predisposing condition is denture use, which also increases in the elderly. To test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of carriage, the multiplicity of species, and the genetic relatedness of strains in the oral cavities of 93 test subjects separated into the three age groups: 60 to 69 yr, 70 to 79 yr, and > or = 80 yr. Each age group was further subdivided into subjects with and without dentures, and into males and females. The results demonstrate that the frequency of carriage, the intensity of carriage, and multispecies carriage all increase as a function of age and differ according to gender, in both cases independent of denture use, suggesting that the natural suppression of yeast carriage in the oral cavity breaks down in the elderly. In addition, it is demonstrated that Candida glabrata colonizes the oral cavities of elderly individuals without dentures only after 80 yr of age, suggesting that there are age-related compromising conditions other than denture use in this most elderly age group.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Lockhart SR,Joly S,Vargas K,Swails-Wenger J,Enger L,Soll DRdoi
10.1177/00220345990780040601keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
857-68issue
4eissn
0022-0345issn
1544-0591journal_volume
78pub_type
杂志文章abstract：:Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within s...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/0022034519837252
更新日期：2019-06-01 00:00:00
abstract：:The role of Streptococcus mutans in the initiation of dental caries has been recognized and attributed, at least in part, to its ability to colonize the tooth surface. Therefore, factors which prevent S. mutans attachment to hydroxyapatite (HA) are of considerable interest for the prophylaxis of this infectious diseas...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760020701
更新日期：1997-02-01 00:00:00
abstract：:Several studies have shown that surgical detachment of marginal gingiva close to the cervical cementum of molar teeth in a rat mandible is a distinct stimulus for alveolar bone resorption. Recently, we found that P2X4, an ATP-receptor, is significantly up-regulated in marginal gingival cells soon after surgery. We hyp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600214
更新日期：2007-02-01 00:00:00
abstract：:Synovial hyperplasia is a feature of degenerative temporomandibular joint (TMJ) disease. However, the mechanism by which hyperplasia progresses in the TMJ is unknown. Based on the hypothesis that the oxidative stress generated by mechanical loading causes degenerative changes in the TMJ synovium, we investigated the g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300807
更新日期：2004-08-01 00:00:00
abstract：:The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, or ...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910608500706
更新日期：2006-07-01 00:00:00
abstract：:Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345970760100901
更新日期：1997-10-01 00:00:00
abstract：:Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513509280
更新日期：2013-12-01 00:00:00
abstract：:Cultures of Streptococcus mutans MFe28 (serotype h) were grown with differing extracellular polysaccharide (EPS) content. Biochemical and physicochemical characteristics considered relevant to caries were measured. Acid production parameters measured in a pH-stat were: Vm = 0.76 +/- 0.14 mumol/g/sec (wet weight); appa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060101
更新日期：1988-06-01 00:00:00
abstract：:Short-chain carboxylic acids (e.g., lactic acid, propionic acid, butyric acid) are metabolic by-products of bacterial metabolism which can accumulate in the gingival crevice. It is of no small consequence, therefore, that 1- to 5-mM concentrations of these acids exhibit significant biological activity, including the a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760010801
更新日期：1997-01-01 00:00:00
abstract：:The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910808700802
更新日期：2008-08-01 00:00:00
abstract：:The cartilaginous nasal septa of 28 albino rats were marked with pairs of wire implants. Measurements obtained from cephalometric radiographs taken at 30 and 60 days revealed that the implants invariably separatd and did so at a rate that was highly correlated with the growth of the rest of the snout. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590081601
更新日期：1980-08-01 00:00:00
abstract：:Obesity is a widespread chronic inflammatory disorder characterized by an increased overall disease burden and significant association with periodontitis. The aim of this prospective clinical cohort study was to investigate the effect of obesity on orthodontic tooth movement. Fifty-five adolescent patients (27 males, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516688448
更新日期：2017-05-01 00:00:00
abstract：:The purpose of this investigation was to determine whether chlorhexidine combined with copper would exert a synergistic, growth-inhibitory effect against selected oral bacteria. Actinomyces viscosus, Actinomyces naeslundii, and Streptococcus mutans were all susceptible to chlorhexidine individually, with S. mutans dis...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720020901
更新日期：1993-02-01 00:00:00
abstract：:Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective tissue. This study investigated the hypothesis that diabetes impairs connective tissue formation in healing gingiva, and that impaired healing is associated with ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510362960
更新日期：2010-06-01 00:00:00
abstract：:The purpose of the work described here was to investigate the mechanisms involved in the binding of salivary alpha-amylase to Streptococcus gordonii NCTC 7868 (Challis). Of six types of alpha-amylase studied, only mammalian forms of the enzyme were found to bind to S. gordonii cells. Salivary alpha-amylase binding was...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690110701
更新日期：1990-11-01 00:00:00
abstract：:The presence and kinetics of bone-resorbing activity in periapical lesions were studied with a rat model system. Lesions were found to expand most rapidly between induction on day 0 and day 15 ("active phase"), with enlargement occurring at a slower rate thereafter (days 20 and 30, "chronic phase"), as assessed by mea...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700100901
更新日期：1991-10-01 00:00:00
abstract：:Cementum forms the interface between root dentin and periodontal ligament through which periodontal connective tissue is attached to root surfaces. We have examined how cementum components influence the biological activities of gingival fibroblasts. Cementum was harvested from freshly extracted human teeth and extract...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660082301
更新日期：1987-08-01 00:00:00
abstract：:Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580101501
更新日期：1979-10-01 00:00:00
abstract：:The oral microbiome is one of the most stable ecosystems in the body and yet the reasons for this are still unclear. As well as being stable, it is also highly diverse which can be ascribed to the variety of niches available in the mouth. Previous studies have focused on the microflora in disease-either caries or peri...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
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abstract：:Dental epithelial progenitor cells differentiate into various cell types during development of tooth germs. To study this mechanism, we produced immortalized dental epithelial progenitor cells derived from the cervical-loop epithelium of a rat lower incisor. The expression patterns of cytokeratin 14, nerve growth fact...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300209
更新日期：2004-02-01 00:00:00
abstract：:The tongue plays an important role in mastication and swallowing by its contact with the hard palate. Using an experimental palatal plate with 7 pressure sensors, and recording jaw movement using mandibular kinesiography, we assessed, in healthy subjects, the coordination of tongue and jaw movements during the entire ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500214
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abstract：:With the objective of contributing to the understanding of factors influencing the characteristics of dentition, dental observations from 429 children and adult highland people of western Bolivia are described. Various age, sex, ethnic, and village differences are observed in malocclusion, dental caries, periodontal d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570030901
更新日期：1978-03-01 00:00:00
abstract：:The expired air of a group of 48 persons, 40 with and eight without dental amalgam restorations, was analyzed for its mercury content before and after chewing. Expired air samples were collected in polyethylene bags, and a known quantity of each was pumped into the mercury detector for measurement. The results showed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600090601
更新日期：1981-09-01 00:00:00
abstract：:The influence of the molecular weight of the poly(acrylic acid) component on some properties of glass-ionomer cement has been investigated. The results can be explained by treatment of glass-ionomer cements as thermoplastic composites. Many of the concepts of polymer science can be applied successfully in a qualitativ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680021401
更新日期：1989-02-01 00:00:00
abstract：:Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable of withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism by which inflamed odontoblasts are protected fro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519869580
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abstract：:The range of substrates transported by the sugar-binding protein-dependent msm (multiple sugar metabolism) system of S. mutans was investigated. By determining the ability of unlabeled sugar to compete with radiolabeled melibiose transport, we have demonstrated that the transported sugars included a number of carbohyd...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720100701
更新日期：1993-10-01 00:00:00
abstract：:This paper discusses loosely bound fluoride and its role in dental caries and prevention. Loosely bound fluoride (abbr. by Fa) is fluoride adsorbed onto enamel mineral crystallites. Several recent studies indicate that a high total level of fluoride in enamel does not guarantee protection against caries. This leads to...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690S118
更新日期：1990-02-01 00:00:00
abstract：:Previous studies have shown that fluoride affected the formation of apatite in spontaneous precipitations from unstable calcium phosphate solutions partly through its effect on the stability of such nonapatitic precursors as octacalcium phosphate, Ca8H2(PO4)6.5 H2O. The present study shows that fluoride had a comparab...
journal_title：Journal of dental research
pub_type： 杂志文章
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更新日期：1980-02-01 00:00:00
abstract：:Periodontal data typically consist of observations made at multiple sites within each patient. Observations within a patient tend to be positively correlated; hence, standard statistical techniques that assume independence are invalid. Regression techniques for correlated data have been proposed; communicating results...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200705
更新日期：2003-07-01 00:00:00
abstract：:In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
