Abstract：
:Short-chain carboxylic acids (e.g., lactic acid, propionic acid, butyric acid) are metabolic by-products of bacterial metabolism which can accumulate in the gingival crevice. It is of no small consequence, therefore, that 1- to 5-mM concentrations of these acids exhibit significant biological activity, including the ability to alter cell proliferation and gene expression in cells of importance to the periodontium. This communication reports on the in vivo concentrations of propionic and butyric acid in the gingival crevices of periodontal subjects with severe and mild disease. The results indicated that severely diseased subjects exhibited a > 10-fold increase in the mM concentration of these acids when compared with mildly diseased subjects (mean propionic acid-severe = 9.5 +/- 1.8 mM, and mild = 0.8 +/- 0.3 mM; mean butyric acid-severe = 2.6 +/- 0.4 mM, and mild = 0.2 +/- 0.04 mM). These differences (mean +/- SE) were significant (p < 0.0001). The propionic and butyric acid concentrations were below detection limits in healthy sites of mildly diseased subjects. The propionic and butyric acid concentrations also associated significantly with clinical measures of disease severity (e.g., pocket depth, attachment level) and inflammation (e.g., subgingival temperature, % of sites bleeding when probed), and with the total microbial load (all p < 0.05). Taken together, these data suggest that short-chain carboxylic acids play a mediating role in periodontal disease pathogenesis.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Niederman R,Buyle-Bodin Y,Lu BY,Robinson P,Naleway Cdoi
10.1177/00220345970760010801subject
Has Abstractpub_date
1997-01-01 00:00:00pages
575-9issue
1eissn
0022-0345issn
1544-0591journal_volume
76pub_type
杂志文章abstract：:We tested whether orthodontic tooth movement (OTM) could be blocked by local administration of echistatin or an arginine-glycine-aspartic acid (RGD) peptide, agents known to perturb bone remodeling, adjacent to maxillary molars in rats. These molecules were incorporated into ethylene-vinyl acetate (ELVAX), a non-biode...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200905
更新日期：2003-09-01 00:00:00
abstract：:Mixtures containing two bacterial species were analyzed using flow cytometric techniques. Light scattering characteristics of Streptococcus mutans and Actinomyces viscosus show unique profiles for pure cultures. However, the light scatter analysis of a mixture containing these two species demonstrates overlapping near...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630080501
更新日期：1984-08-01 00:00:00
abstract：:Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis). The severity of dental fluorosis is also dependent upon fluoride dose and the timing and duration of fluoride exposure. ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034510384626
更新日期：2011-05-01 00:00:00
abstract：:Recent functional animal studies have reported that the motor control of masticatory muscle function is bilaterally guided by both hemispheres, which may fundamentally differ from the cortical control of limb muscle function. In this study, we investigated whether unilateral cortical brain infarction induces different...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780120701
更新日期：1999-12-01 00:00:00
abstract：:The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570010901
更新日期：1978-01-01 00:00:00
abstract：:Schoolchildren residing in a fluoride-deficient area were provided either a sodium fluoride (0.1% F) or a nonfluoride dentifrice for home use. About half the children provided each type of dentifrice were also given an initial prophylaxis. Combining the data with regard to the type of dentifrice indicated that the sod...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345750540013601
更新日期：1975-01-01 00:00:00
abstract：:Previous studies have shown that extracts of various filling materials, e.g., resin composites, may influence the growth of cariogenic micro-organisms. The purpose of this study was to examine the effects of important resin composite (co)monomers (Bis-GMA, UDMA, TEGDMA, EGDMA) and extracts of two commercial dental com...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770010601
更新日期：1998-01-01 00:00:00
abstract：:Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515611876
更新日期：2016-02-01 00:00:00
abstract：:The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345870660101301
更新日期：1987-10-01 00:00:00
abstract：:A conceptual means of obtaining improved bonding between filler particles and the polymeric binders of composites is presented. It involves preparing glass particles that separate into two interconnected vitreous phases when heated to an appropriate temperature, and then etching these to produce a porous surface layer...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550050701
更新日期：1976-09-01 00:00:00
abstract：:The cacao bean husk has been shown to possess two types of cariostatic substances, one showing anti-glucosyltransferase (GTF) activity and the other antibacterial activity, and to inhibit experimental dental caries in rats infected with mutans streptococci. In the present study, chromatographic purification revealed h...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800111001
更新日期：2001-11-01 00:00:00
abstract：:A multiple logistic regression analysis was used to compute the odds ratios for 11 common occlusal features for asymptomatic controls (n = 147) vs. five temporomandibular disorder groups: Disc Displacement with Reduction (n = 81), Disc Displacement without Reduction (n = 48), Osteoarthrosis with Disc Displacement Hist...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720061301
更新日期：1993-06-01 00:00:00
abstract：:Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Macroscopically, no side-effect was observed in the gingiva and associated structures. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610121401
更新日期：1982-12-01 00:00:00
abstract：:Lysozyme concentration was quantitated immunochemically in parotid and submandibular-sublingual saliva of 46 caries-resistant and 17 caries-susceptible adults. There was essentially no difference between the two groups. The concentration of lysozyme was three times higher in the submandibular-sublingual than in the pa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620050701
更新日期：1983-05-01 00:00:00
abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520913873
更新日期：2020-07-01 00:00:00
abstract：:The Global Burden of Disease (GBD) 2010 Study produced comparable estimates of the burden of 291 diseases and injuries in 1990, 2005, and 2010. This article reports on the global burden of untreated caries, severe periodontitis, and severe tooth loss in 2010 and compares those figures with new estimates for 1990. We u...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513490168
更新日期：2013-07-01 00:00:00
abstract：:Pulpal blood flow was determined in 32 dogs ranging in age from 6 weeks to 18 months by the isotope fractionation method incorporating diffusible and nondiffusible tracers. Dogs were placed into selected age groups by the developmental status of the canine teeth. For the teeth sampled, the maxillary first, second, and...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560102601
更新日期：1977-10-01 00:00:00
abstract：:There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625907
更新日期：2016-04-01 00:00:00
abstract：:A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560110301
更新日期：1977-11-01 00:00:00
abstract：:Gingival overgrowth tissues have thickened connective tissue stroma, sometimes accompanied by the increased presence of collagen fibers, thickened epithelia, and elongated rete pegs. We have previously shown that expression of CCN2, also known as connective tissue growth factor (CTGF), correlates positively with the d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511404703
更新日期：2011-07-01 00:00:00
abstract：:Acidic proline-rich proteins were localized histologically by means of the indirect immunoperoxidase technique in the acinar cells of parotid and submandibular gland sections of both man and Macaca fascicularis. These proteins were also identified as constituents of the long term in vivo-formed acquired pellicle on hu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590081201
更新日期：1980-08-01 00:00:00
abstract：:Two series of dental composites, along with the unfilled resin matrix, were examined to determine the effects of filler level and size on selected properties. Both series were prepared by incorporating a silanated barium borosilicate filler into a visible-light-activated polyphenylene polymethacrylate resin matrix. On...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121501
更新日期：1985-12-01 00:00:00
abstract：:Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibula...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300107
更新日期：2004-01-01 00:00:00
abstract：:Oral bacteria, including Streptococcus mutans and Streptococcus salivarius, contribute to tooth decay and plaque formation; therefore, it is essential to develop strategies to prevent dental caries and plaque formation. We recently showed that organo-selenium compounds covalently attached to different biomaterials inh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513482141
更新日期：2013-05-01 00:00:00
abstract：:The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515593055
更新日期：2015-10-01 00:00:00
abstract：:The present investigation demonstrates that direct application of a composite resin on an acid-etched, vital dentin surface is hazardous to the pulp in monkey teeth. This indicates that exposed dentin should be protected before treating the tooth with a restorative technique including acid etching. A ca(OH)2-containin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550022001
更新日期：1976-03-01 00:00:00
abstract：:Catecholamines are present in saliva, but their influence on oral epithelium is not understood. Because psychological stress increases salivary catecholamines and impairs oral mucosal wound healing, we sought to determine if epithelial adrenergic signaling could link these two findings. We found that cultured human or...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510388034
更新日期：2011-02-01 00:00:00
abstract：:Rat parotid atrophy, induced by liquid feeding over 10 days, was manifested as gland weight loss (40%) and histologically as acinar shrinkage. Acinar secretory function was investigated in the same glands using enzymatically dispersed cell preparations and superfused gland slices. Results were normalized for the acina...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730060901
更新日期：1994-06-01 00:00:00
abstract：:The tongue plays an important role in mastication and swallowing by its contact with the hard palate. Using an experimental palatal plate with 7 pressure sensors, and recording jaw movement using mandibular kinesiography, we assessed, in healthy subjects, the coordination of tongue and jaw movements during the entire ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500214
更新日期：2006-02-01 00:00:00
abstract：:Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). T...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400609
更新日期：2005-06-01 00:00:00
