Kinetics of bone-resorbing activity in developing periapical lesions.

abstract：:Selective recruitment of periodontal ligament cells to a previously exposed root surface is believed to enhance periodontal regeneration. It has been hypothesized that competition from gingival fibroblasts may reduce the potential of periodontal regeneration. We compared the migratory responses of PDL cells and gingiv...

journal_title：Journal of dental research

authors： Nishimura F,Terranova VP

更新日期：1996-04-01 00:00:00

abstract：:The effects of substituting gluconate for extracellular Cl, and of treatment with various ion transport blockers, on cytosol pH (pHi) and secretion by the acetylcholine stimulated rat mandibular gland were studied in vitro. Gluconate replacement increased pHi from 7.12 +/- 0.02 to 7.27 +/- 0.04, caused secretory rate ...

journal_title：Journal of dental research

authors： Young JA,Cook DI,Evans LA,Pirani D

更新日期：1987-02-01 00:00:00

abstract：:The Wingless/integrase-1 (Wnt) family of protein ligands and their functional antagonists, secreted frizzled-related proteins (sFRPs), regulate various biological processes ranging from embryonic development to immunity and inflammation. Wnt5a and sFRP5 comprise a typical ligand/antagonist pair, and the former molecul...

journal_title：Journal of dental research

authors： Maekawa T,Kulwattanaporn P,Hosur K,Domon H,Oda M,Terao Y,Maeda T,Hajishengallis G

更新日期：2017-05-01 00:00:00

abstract：:In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpr...

journal_title：Journal of dental research

authors： Thieme F,Ludwig KU

更新日期：2017-10-01 00:00:00

abstract：:Ten cats were immunized with subcutaneous injections of keyhole limpet hemocyanin (KLH). After it was determined that the experimental animals had developed circulating antibodies to KLH, challenge doses of KLH were administered via the root canal system. The radiographic and histologic findings suggest that antigen-a...

journal_title：Journal of dental research

authors： Torabinejad M,Kiger RD

更新日期：1980-01-01 00:00:00

abstract：:Cementum forms the interface between root dentin and periodontal ligament through which periodontal connective tissue is attached to root surfaces. We have examined how cementum components influence the biological activities of gingival fibroblasts. Cementum was harvested from freshly extracted human teeth and extract...

journal_title：Journal of dental research

authors： Miki Y,Narayanan AS,Page RC

更新日期：1987-08-01 00:00:00

abstract：:A plaque growth chamber was developed for long-term growth of five separate plaques from the same plaque or saliva sample under identical conditions of temperature and gas phase. Reagent addition and growth conditions for each plaque could be independently controlled, and each was accessible for sequential sampling an...

journal_title：Journal of dental research

authors： Sissons CH,Cutress TW,Hoffman MP,Wakefield JS

更新日期：1991-11-01 00:00:00

abstract：:These studies defined the normal and hormonally altered development of activity for tyrosine hydroxylase (T-OH), the rate-limiting enzyme in catecholamine biosynthesis (Levitt et al., 1965), and choline acetyltransferase activity (CAT) in the male rat superior cervical ganglion (SCG). Additionally, salivary gland weig...

journal_title：Journal of dental research

authors： Melvin JE,Hamill RW

更新日期：1987-03-01 00:00:00

abstract：:To identify salivary biomarkers of periodontal diseases, we used plaque-resistant and -susceptible rats as animal models. The levels of salivary cystatin S in saliva, salivary glands, and gingiva were tested in Nembutal-anesthetized young and adult plaque-resistant and -susceptible rats of both sexes with and without ...

journal_title：Journal of dental research

authors： Abe K,Okina A,Yano T,Gao C,Ohmori H,Ishibashi K,Nishiura T,Letić-Gavrilović A

更新日期：1998-11-01 00:00:00

abstract：:The temporal and spatial patterns in which teeth are initiated in the growing jaws of embryos are constant for a species but different for different species. The sources of the patterns have been explained in two ways. First, they are the outcome of reactions between molecules created at stationary targets and those w...

journal_title：Journal of dental research

authors： Osborn JW

更新日期：1998-09-01 00:00:00

abstract：:For practical reasons, evaluation of topical fluoride products must depend upon clinical and laboratory assessments. While not always a good predictor of clinical efficacy by itself, fluoride uptake is the most commonly used laboratory test. A consideration of the relationship between possible anticaries mechanisms of...

journal_title：Journal of dental research

authors： Mellberg JR

更新日期：1990-02-01 00:00:00

abstract：:The periodontium contains heterogeneous mesenchymal cell populations with various differentiation potentials. The capacity of these cells for tissue formation as well as the origin of their precursors are still not entirely defined. In this study, cells originating from different periodontal tissues were cultured in v...

journal_title：Journal of dental research

authors： Lang H,Schüler N,Arnhold S,Nolden R,Mertens T

更新日期：1995-05-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage pain and inflammatory disorders. We hypothesized that gingival fibroblasts actively accumulate NSAIDs and enhance their levels in gingival connective tissue. Using fluorescence to monitor NSAID transport, we demonstrated that cultured gingival fibroblas...

journal_title：Journal of dental research

authors： Zavarella MM,Gbemi O,Walters JD

更新日期：2006-05-01 00:00:00

abstract：:Medication-related osteonecrosis of the jaw (MRONJ), although initially believed to be exclusively associated with bisphosphonates, has been implicated in recent reports with additional drugs, especially the bone antiresorptive denosumab. The pathophysiology has not been fully elucidated, and no causal association bet...

journal_title：Journal of dental research

authors： Katsarelis H,Shah NP,Dhariwal DK,Pazianas M

更新日期：2015-04-01 00:00:00

abstract：:Conservative techniques for improving the appearance of discolored teeth have become popular in the past decade. These include: in-office bleaching with 30% hydrogen peroxide, which is applied on etched enamel with a gauze pad and then exposed to a bleaching light; home bleaching with a mild form of peroxide, such as ...

journal_title：Journal of dental research

authors： Tong LS,Pang MK,Mok NY,King NM,Wei SH

更新日期：1993-01-01 00:00:00

abstract：:Antigenic alterations to the dentin organic matrix may be detected by an immunohistochemical approach. We hypothesized that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions. Transverse sections were prepared from carious teeth in the sclerotic zone and...

journal_title：Journal of dental research

authors： Suppa P,Ruggeri A Jr,Tay FR,Prati C,Biasotto M,Falconi M,Pashley DH,Breschi L

更新日期：2006-02-01 00:00:00

abstract：:Alendronate (ALN) is an antiresorptive agent widely used for the treatment of osteoporosis. Its suppressive effect on osteoclasts has been extensively studied. However, the effect of ALN on bone formation is not as clear as its effect on resorption. The objective was to determine the effect of short-term ALN on bone f...

journal_title：Journal of dental research

authors： Tanoue R,Koi K,Yamashita J

更新日期：2015-09-01 00:00:00

abstract：:Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...

journal_title：Journal of dental research

authors： Chan HC,Mai L,Oikonomopoulou A,Chan HL,Richardson AS,Wang SK,Simmer JP,Hu JC

更新日期：2010-07-01 00:00:00

abstract：:As an approach for improving the outcome and predictability of periodontal regenerative therapies, we have focused on determining the responses of cells within the local environment to putative regenerative factors. This study examined the effects of bone morphogenetic protein-2 (BMP-2) on murine cementoblasts in vitr...

journal_title：Journal of dental research

authors： Zhao M,Berry JE,Somerman MJ

更新日期：2003-01-01 00:00:00

abstract：:In a three-year study of 145 adolescent males in a boarding school in Wisconsin, there were no statistically significant differences in dental caries experience between a group consuming phosphates added to pre-sweetened and non-presweetened ready-to-eat cereals, and the control group, or between cereal eaters and non...

journal_title：Journal of dental research

authors： Wilson CJ

更新日期：1979-09-01 00:00:00

abstract：:The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...

journal_title：Journal of dental research

authors： Schreiber CT,Shern RJ,Chow LC,Kingman A

更新日期：1988-06-01 00:00:00

abstract：:During the 18th century, France was the leader in the field of dentistry, exemplified by Pierre Fauchard (1678-1761), who was given the title "the father of modern dentistry" for his comprehensive work, Le Chirurgien Dentiste. This paper examines an 18th century dental treatment in a barely 50-year-old male whose body...

journal_title：Journal of dental research

authors： Bertrand B,Colard T,Lacoche C,Salomé JF,Vatteoni S

更新日期：2009-03-01 00:00:00

abstract：:Several studies indicated that serotype/biotype c strains are the most common on a global basis, but that regional differences may occur relative to other serotype/biotypes. Of particular interest is the observation that individuals residing in the Middle East have higher incidences of serotype e and d strains relativ...

journal_title：Journal of dental research

authors： Farghaly MM,Eklund S,Loesche WJ

更新日期：1984-01-01 00:00:00

abstract：:The balance between bone resorption and bone formation is vital for maintenance and regeneration of alveolar bone and supporting structures around teeth and dental implants. Tissue regeneration in the oral cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions. A goal for periodontal...

journal_title：Journal of dental research

authors： Larsson L,Decker AM,Nibali L,Pilipchuk SP,Berglundh T,Giannobile WV

更新日期：2016-03-01 00:00:00

abstract：:The surface enamel of fetal bovine teeth was stained with GBHA to indicate the position of bands of smooth-ended and ruffle-ended ameloblasts relative to the developing enamel. The boundaries of the bands were scored, under a dissecting microscope, and the bulk enamel under each band was collected. The enamel samples ...

journal_title：Journal of dental research

authors： Bawden JW,Keels MA,Deaton TG,Crenshaw MA

更新日期：1988-06-01 00:00:00

abstract：:The most frequent complaints registered against composite restorations are stained margins and a rough surface. The stained margins have many causes such as (1) fracturing or crazing of enamel during preparation of the cavity, (2) using a composite having an excessive curing shrinkage, (3) manipulating too slowly, whi...

journal_title：Journal of dental research

authors： Rupp NW

更新日期：1979-05-01 00:00:00

abstract：:Dental caries is initiated by demineralization of the tooth surface through acid production by sugar metabolism of supragingival plaque microflora. To elucidate the sugar metabolic system, we used CE-MS to perform metabolomics of the central carbon metabolism, the EMP pathway, the pentose-phosphate pathway, and the TC...

journal_title：Journal of dental research

authors： Takahashi N,Washio J,Mayanagi G

更新日期：2010-12-01 00:00:00

abstract：:Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...

journal_title：Journal of dental research

authors： Marek M

更新日期：1990-05-01 00:00:00

abstract：:The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF(2)) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF(2) formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase ...

journal_title：Journal of dental research

authors： Tenuta LM,Cerezetti RV,Del Bel Cury AA,Tabchoury CP,Cury JA

更新日期：2008-11-01 00:00:00

abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...

journal_title：Journal of dental research

authors： Crowe DL,Milo GE,Shuler CF

更新日期：1999-06-01 00:00:00