Abstract：
:The effects of substituting gluconate for extracellular Cl, and of treatment with various ion transport blockers, on cytosol pH (pHi) and secretion by the acetylcholine stimulated rat mandibular gland were studied in vitro. Gluconate replacement increased pHi from 7.12 +/- 0.02 to 7.27 +/- 0.04, caused secretory rate to fall by 75%, and increased salivary HCO3 from 14 +/- 0.9 mmol/L to 67 +/- 1.5 mmol/L. Furosemide (1 mmol/L), which blocks Na-K-2Cl symports and Cl-HCO3 antiports, had effects similar to those of gluconate replacement, except that secretion was reduced only by 59%. Bumetanide (1 mmol/L), which blocks only Na-K-2Cl symports, caused a 67% reduction in secretion rate, but it had little effect on pHi and caused only a small rise in salivary HCO3 concentration. SITS (1 mmol/L), which blocks Cl-HCO3 antiports, increased pHi to 7.26 +/- 0.03 and induced a small rise in the secretory rate. Methazolamide and acetazolamide (1 mmol/L), both of which inhibit carbonic anhydrase and may also block anion channels, increased pHi to 7.43 +/- 0.02 and 7.20 +/- 0.03, respectively, but had no effect on secretory rate, and reduced salivary HCO3 slightly. Ba (3 mmol/L), tetraethylammonium (10 mmol/L), and decamethonium (5 mmol/L) all caused marked but reversible reductions in secretory rate, consistent with the known actions of these agents on K channels. Ba, however, also appeared to act as a Ca antagonist, an action that it seemed to share with Mn ions (5 mmol/L).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Young JA,Cook DI,Evans LA,Pirani Ddoi
10.1177/00220345870660022401subject
Has Abstractpub_date
1987-02-01 00:00:00pages
531-6issue
2eissn
0022-0345issn
1544-0591journal_volume
66pub_type
杂志文章abstract：:Modulation of the phosphoinositide signal transduction pathway by arachidonic acid (AA) in collagenase-dispersed rat submandibular acinar cells was investigated. The muscarinic agonist, carbachol, stimulated PIP2 hydrolysis and the generation of IP3 to five-fold the control levels. This response was inhibited by 75% o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710080101
更新日期：1992-08-01 00:00:00
abstract：:A double-blind randomized clinical trial was performed in 6- to 7-yr-old schoolchildren to evaluate, in a 30-mo period, whether the caries increment on the distal surface of the second primary molars adjacent to permanent first molars sealed with fluoride release compounds would be lower with respect to those adjacent...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034514535808
更新日期：2014-07-01 00:00:00
abstract：:Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Improved mechanical properties of resin composites have been reported to be a consequence of the addition of aldehyde to the resins. The objective of the present study was to examine whether this improvement could be attributed to an increased degree of conversion of double bonds. For this purpose, propanal was added ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730101101
更新日期：1994-10-01 00:00:00
abstract：:Relative glycogen synthetic abilities of resting cells of fresh clinical isolates of Actinomyces viscosus and Actinomyces naeslundii originating from dental plaque samples over root surface caries lesions and non-carious sites were studied under anaerobic conditions at a constant pH of 7.0, with U-(14C)-glucose used a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650060701
更新日期：1986-06-01 00:00:00
abstract：:Antimicrobial agents, delivered either by mouthrinse or toothpaste, can be used to maintain plaque at levels compatible with oral health by (a) reducing existing plaque, (b) preventing the formation of new plaque, (c) selectively inhibiting those particular bacteria that are associated with disease, and (d) inhibiting...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345920710071501
更新日期：1992-07-01 00:00:00
abstract：:Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1beta and tumor necrosis factor-alpha (TNF-alpha), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinas...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600409
更新日期：2007-04-01 00:00:00
abstract：:Amylase activity in various tissues--i.e., submandibular/sublingual and parotid glands, the pancreas, saliva, and serum--in rats was measured after injection of isoproterenol, pilocarpine, and acetylcholine. All agents reduced amylase activity in the parotid gland and increased the enzyme activity in the submandibular...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620011201
更新日期：1983-01-01 00:00:00
abstract：:The effect of combined administration of chlorhexidine and fluoride in the drinking water of hamsters on plaque and caries prevention was studied. Plaque indices of the hamsters receiving chlorhexidine either alone or simultaneously with fluoride were significantly lower than those of the control and fluoride only tre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560111401
更新日期：1977-11-01 00:00:00
abstract：:The effect of low-level laser treatment on maxillary arch dimensions after palatal surgery was investigated in Beagle dogs at an age of 12 weeks. A total of 30 dogs was used, and they were assigned to either a control group (Group C, n = 6) or one of two experimental groups (Group L, n = 12; and group LL, n = 12). Aft...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700111501
更新日期：1991-11-01 00:00:00
abstract：:The frequency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing the joint's function. The 6 discal attachments have not yet been systematically characterized under tension. Understanding their role in joint function may guide our study of TMJ pathologies, including disc displ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513494817
更新日期：2013-08-01 00:00:00
abstract：:Fungal infections in the oral cavity are mainly caused by C. albicans, but other Candida species are also frequently identified. They are increasing in prevalence, especially in denture-wearers and aging people, and may lead to invasive infections, which have a high mortality rate. Attachment to mucosal tissues and to...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034508329273
更新日期：2009-02-01 00:00:00
abstract：:The most frequent complaints registered against composite restorations are stained margins and a rough surface. The stained margins have many causes such as (1) fracturing or crazing of enamel during preparation of the cavity, (2) using a composite having an excessive curing shrinkage, (3) manipulating too slowly, whi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580052101
更新日期：1979-05-01 00:00:00
abstract：:Evaluation of long-term mechanical behavior of new types of restorations in clinical trials is time-consuming. A partial alternative can be found in experimental fatigue-testing, which simulates accelerated mechanical deterioration. The aim of this study was to determine the feasibility of using fatigue-testing of a c...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345920710050301
更新日期：1992-05-01 00:00:00
abstract：:Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable of withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism by which inflamed odontoblasts are protected fro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519869580
更新日期：2019-10-01 00:00:00
abstract：:Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513490958
更新日期：2013-08-01 00:00:00
abstract：:Adenosine has various biological effects on human gingival fibroblasts (HGF) and epithelial cells closely associated with inflammation, such as cytokine production and cell adhesion. However, the mechanism of adenosine formation in periodontal tissues is not yet defined. In this study, we examined the involvement of C...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308201108
更新日期：2003-11-01 00:00:00
abstract：:The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720051401
更新日期：1993-05-01 00:00:00
abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780061001
更新日期：1999-06-01 00:00:00
abstract：:The relationship between occlusal stimuli and a hypofunctional periodontal ligament (PDL) structure has been reported, though changes in occlusal recovery conditions were still unclear. Nitric oxide (NO) produced by NO synthase (NOS) is considered a factor for vascular and immune system control, and it increases accor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300413
更新日期：2004-04-01 00:00:00
abstract：:To determine the 'hard palate representing' area in the primary somatosensory cortex, we recorded somatosensory-evoked magnetic fields from the cortex in ten healthy volunteers, using magnetoencephalography. Following electrical stimulation of 3 sites on the hard palate (the first and third transverse palatine ridges,...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600313
更新日期：2007-03-01 00:00:00
abstract：:It has been shown that a release of periosteal tension may augment the growth of a long bone; however, similar experiments in the mandible have produced equivocal results. For further definition of the role of periosteal tension in the growth of the mandibular condyle, 80 young female Sprague-Dawley rats were randomly...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690090201
更新日期：1990-09-01 00:00:00
abstract：:Enamel abraders used in two-body wear tests suffer the disadvantage that standardization is difficult or impossible to obtain. The aim of this study was to test whether steatite (a ceramic material with a Vickers Hardness similar to that of enamel) could be used as a satisfactory human enamel analogue. The friction an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730091001
更新日期：1994-09-01 00:00:00
abstract：:In order for the role of parotid amylase in starch digestion in the gastro-intestinal tracts of diabetic rats to be clarified, this study investigated the effect of parotid-duct ligation on both amylase secretion from the parotid glands and pancreas into the gastro-intestinal tract and on starch digestion in the gastr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680091501
更新日期：1989-09-01 00:00:00
abstract：:Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034514529150
更新日期：2014-07-01 00:00:00
abstract：:During orofacial tissue development, the anterior and posterior regions of the Meckel's cartilage undergo mineralization, while the middle region undergoes degeneration. Despite the interesting and particular phenomena, the mechanisms that regulate the different fates of Meckel's cartilage, including the effects of bi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520960118
更新日期：2021-02-01 00:00:00
abstract：:Interfacial bonding and stability of gamma-methacryloxypropyltrimethoxysilane with silica surfaces have been studied by means of infrared spectroscopy. The addition of n-propylamine enhances silanization of gamma-methacryloxypropyltrimethoxysilane to silica surfaces in normal aliphatic hydrocarbons, and cyclohexane yi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610121301
更新日期：1982-12-01 00:00:00
abstract：:Fluid transudation through simplified dentin adhesives can occur in bonded vital crown dentin, since these adhesives behave as permeable membranes after polymerization. The effect of adhesive permeability in endodontically treated teeth is unknown. This study examined the hypothesis that in vivo fluid movement through...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910508400303
更新日期：2005-03-01 00:00:00
abstract：:During the maintenance of bone marrow-derived mesenchymal stem cells (BMMSCs), suspended cells are discarded normally. We noted the osteogenic potential of these cells to be like that of anchorage-dependent BMMSCs. Therefore, we characterized suspended BMMSCs from rabbit bone marrow by bioengineering and applied the s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514548706
更新日期：2014-10-01 00:00:00
abstract：:We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean Na...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518814829
更新日期：2019-02-01 00:00:00
