Abstract：
:For practical reasons, evaluation of topical fluoride products must depend upon clinical and laboratory assessments. While not always a good predictor of clinical efficacy by itself, fluoride uptake is the most commonly used laboratory test. A consideration of the relationship between possible anticaries mechanisms of fluoride, different product types, and the meaning of various kinds of fluoride uptake data suggests that both the amount of fluoride taken up by early lesions and the amount of ambient fluoride present at a cariogenic site may play key roles in determining the efficacy of a product. While formulations applied annually or semi-annually probably depend on fluoride deposition, those used daily might not. There are no clear data supporting the superiority of one fluoride compound over another, even for infrequently used products, although there are significant differences among them in fluoride uptake by enamel. This suggests that fluoride uptake in vivo at a cariogenic site might actually be different from that suggested by in vitro data, or that larger differences are required for a clinical effect to be observable. Clinical data support the conclusion that a large increase in the fluoride concentration of a product will somewhat increase its anticaries effectiveness, although the increase will not be linearly related to concentration. There also are no obvious differences in clinical effectiveness caused by the addition of gelling agents to topical solutions. Fluoride varnishes are clinically effective but have not been shown to be superior to topical solutions or gels.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Mellberg JRdoi
10.1177/00220345900690S149subject
Has Abstractpub_date
1990-02-01 00:00:00pages
771-9; discussion 820-3eissn
0022-0345issn
1544-0591journal_volume
69 Spec Nopub_type
杂志文章,评审abstract：:Conventional analyses of the cost-effectiveness of preventive regimens fail to account for the impact of attrition on reported costs. Using an economic model in which costs are allocated to fixed and variable components, and data from a recently completed clinical field trial, costs per participant are shown to vary w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610050601
更新日期：1982-05-01 00:00:00
abstract：:Dental amalgam restorations are a significant source of mercury exposure in the human population, but their potential to cause systemic health effects is highly disputed. We examined effects on the immune system by giving genetically mercury-susceptible Brown Norway (BN) rats and mercury-resistant Lewis (LE) rats silv...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770060601
更新日期：1998-06-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain. The objective of this study was to elucidate the mechanisms whereby CGRP mediated trigeminal neuron-glia crosstalk in modulating orofacial p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520950296
更新日期：2021-01-01 00:00:00
abstract：:Estrogen deficiency results in disruption of maxillary alveolar bone microarchitecture. Most of the actions of estrogen in long bones occur via estrogen receptor α (ERα). However, the function of ERα in the maxillary bone has not been defined. We aimed to investigate the role and underlying mechanisms of ERα in the ph...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516633154
更新日期：2016-06-01 00:00:00
abstract：:Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519872951
更新日期：2019-11-01 00:00:00
abstract：:Bone resorption beneath a maxillary complete denture was simulated by the finite element method, assuming that a threshold of compressive strain exists in the alveolar bone above which the resorption occurred. The pattern of predicted resorption was observed when 100 N of force was applied to three positions occlusall...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680091601
更新日期：1989-09-01 00:00:00
abstract：:A double-blind randomized clinical trial was performed in 6- to 7-yr-old schoolchildren to evaluate, in a 30-mo period, whether the caries increment on the distal surface of the second primary molars adjacent to permanent first molars sealed with fluoride release compounds would be lower with respect to those adjacent...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034514535808
更新日期：2014-07-01 00:00:00
abstract：:A search was made for expression of genes for proline-rich proteins (PRPs) and other salivary-type proteins, including statherin and histatins, in taste-bud tissues of mice and primates because of previous genetic findings in mice (Azen et al., 1986) that Prp and taste genes for certain bitter substances are either th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690110401
更新日期：1990-11-01 00:00:00
abstract：:TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514530164
更新日期：2014-06-01 00:00:00
abstract：:The objectives of the study were to describe the oral health status and treatment needs of the 5- to 6-year-old and 12-year-old children in Southern China; to describe the patterns of oral health behaviors, knowledge, and attitudes among the 12-year-olds; and to assess the effects of socio-behavioral factors on the 12...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800051501
更新日期：2001-05-01 00:00:00
abstract：:Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200406
更新日期：2003-04-01 00:00:00
abstract：:To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514561657
更新日期：2015-02-01 00:00:00
abstract：:A dental appointment commonly prompts fear of a painful experience, yet we have never fully understood how our brains react to the expectation of imminent tooth pain once in a dental chair. In our study, 21 patients with hypersensitive teeth were tested using nonpainful and painful stimuli in a clinical setting. Subje...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515581642
更新日期：2015-07-01 00:00:00
abstract：:The lack of a reliable bond test has hindered the elucidation of the mechanism for porcelain-metal bonding in dental systems, because a test capable of detecting differences among porcelain-metal bonds of various qualities is required before the reasons for these differences may be ascertained. A method was developed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670020801
更新日期：1988-02-01 00:00:00
abstract：:The relative contribution of the matrix of dentin to the physical properties of dentin is unknown but thought to be small. The objective of this study was to test the hypothesis that the demineralized matrix of dentin contributes little to the strength of dentin by measuring and comparing the ultimate tensile strength...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730061201
更新日期：1994-06-01 00:00:00
abstract：:After cheek pouch carcinomas were induced in hamsters by the application of dimethylbenzanthracene (DMBA) to the right pouch for 13 weeks, the animals were divided into four groups and observed for seven more weeks. The control group received no further treatment, two experimental groups had incisional biopsies perfor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650061401
更新日期：1986-06-01 00:00:00
abstract：:Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513516979
更新日期：2014-03-01 00:00:00
abstract：:Teas varying in fluoride and tannin concentration were evaluated in rats for anticariogenic activity. There was a direct correlation between fluoride in tea and the inhibition of sulcal caries in rats, whereas no relationship was observed between tannin and this type of lesion. Teas also had a significant effect on ca...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630051001
更新日期：1984-05-01 00:00:00
abstract：:Investigations of the maturation pattern of rat incisor enamel by quantitative electron microscopy and electron-probe microanalysis indicate that mineralization of rat enamel can be regarded, as in humans, as a regular and progressive process pattern of enamel matrix formation. The species variations that have been pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580024201
更新日期：1979-03-01 00:00:00
abstract：:Strength and durability of the dentin-acrylic resin joint cemented with 2-cyanoacrylate esters were studied. Maximum adhesion is obtained with isobutyl 2-cyanoacrylate after 1% acid pretreatment of the dentin. Hydrolytic stability is somewhat improved by addition of polymer to the adhesive or coating around the joint....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580090901
更新日期：1979-09-01 00:00:00
abstract：:The aim of this study was to examine the association between the bone mass (bone mineral content [BMC]) and hypomineralized second primary molars (HSPMs)/molar incisor hypomineralization (MIH) in 6-y-old children. This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625470
更新日期：2016-04-01 00:00:00
abstract：:Limited cure depth is a drawback of light-activated composites. We hypothesize that curing light transmission and cure depth are influenced by monomer reactivity and filler/resin refractive index mismatch. Light transmission throughout cure was recorded for composites based on strontium (refractive index 1.51) or bari...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700115
更新日期：2008-01-01 00:00:00
abstract：:The effects of various additives on the setting of the glass-ionomer cement system was studied by means of cone and plate viscometry. The action of (+)-tartaric acid, the most important additive, on the setting reaction depended on its concentration. Low concentrations accelerated the development of viscosity of the c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670120101
更新日期：1988-12-01 00:00:00
abstract：:Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduc...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034510373763
更新日期：2010-09-01 00:00:00
abstract：:During the setting of a resin composite cement (RCC) used as an adhesive between a resin-bonded bridge and tooth structure, the adhesion may be disrupted by the development of shrinkage stress. The aim of this study was to investigate the influence of the shrinkage stress of three different RCCs on their adhesive and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710021101
更新日期：1992-02-01 00:00:00
abstract：:Spontaneously occurring bacteriophage-resistant mutants of Actinomyces viscosus were isolated. The mutants exhibited altered coaggregation patterns with streptococci. From analysis of the data, it appears that a cell surface structure on A. viscosus may function both as a phage receptor and as a binding site for co-ag...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620111801
更新日期：1983-11-01 00:00:00
abstract：:A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514541126
更新日期：2014-08-01 00:00:00
abstract：:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520952031
更新日期：2021-01-01 00:00:00
abstract：:The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, or ...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910608500706
更新日期：2006-07-01 00:00:00
abstract：:The mechanism of formation of nodular material on the surface of a Pd-Ag-based alloy for porcelain during pre-porcelainization heat treatment was investigated using scanning electron microscopy, x-ray diffraction, quantitative metallography, and Auger electron spectroscopy. The nodules were found to form by a Nabarro-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620121201
更新日期：1983-12-01 00:00:00
