Randomized Clinical Trial on Sodium Fluoride with Tricalcium Phosphate.


:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Children in group A received a semiannual application of a 25% silver nitrate (AgNO3) solution followed by a commercially available varnish with 5% sodium fluoride (NaF) on the carious tooth surfaces. Children in group B received a semiannual application of a 25% AgNO3 solution followed by another commercially available varnish with 5% NaF containing functionalized tricalcium phosphate (fTCP). Carious tooth surfaces that were hard when probing were classified as arrested. Intention-to-treat analysis and a hierarchical generalized linear model were undertaken. A total of 408 children with 1,831 tooth surfaces with active dentine caries were recruited at baseline, and 356 children (87%) with 1,607 tooth surfaces (88%) were assessed after 24 mo. At the 24-mo evaluation, the mean (SD) number of arrested carious tooth surfaces per child were 1.8 (2.2) and 2.6 (3.3) for group A (without fTCP) and group B (with fTCP), respectively (P = 0.003). The arrest rates at the tooth surface level were 42% for group A and 57% for group B (P < 0.001). Results of the hierarchical generalized linear model indicated that protocol B (with fTCP) had a higher predicted probability (PP = 0.656) in arresting dentine caries than protocol A (without fTCP; PP = 0.500) when the carious lesions were on buccal/lingual surfaces, were on anterior teeth, had dental plaque coverage, and were in children from low-income families (P = 0.046). In conclusion, protocol B, which applied a 25% AgNO3 solution followed by a commercially available 5% NaF varnish with fTCP semiannually, is more effective in arresting dentine caries in primary teeth as compared with protocol A, which applied a 25% AgNO3 solution followed by another commercially available 5% NaF varnish without fTCP semiannually (ClinicalTrials.gov NCT03423797).


J Dent Res


Chen KJ,Gao SS,Duangthip D,Lo ECM,Chu CH




Has Abstract


2021-01-01 00:00:00












  • Effects of porcelain/alloy interfacial diffusion zones on thermo-mechanical strain.

    abstract::Chemical bonding between dental porcelains and alloys results from interdiffusion of porcelain and metal ions. An interfacial diffusion zone is created which, most likely, has properties different from those of bulk materials. The changed interface might affect experimental measurements of thermo-mechanical strain. To...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Tesk JA,Hinman RW,Widera GE,Holmes AD,Cassel JM

    更新日期:1983-05-01 00:00:00

  • Degradation, fatigue, and failure of resin dental composite materials.

    abstract::The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审


    authors: Drummond JL

    更新日期:2008-08-01 00:00:00

  • Thio-urethanes improve properties of dual-cured composite cements.

    abstract::This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-m...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Bacchi A,Dobson A,Ferracane JL,Consani R,Pfeifer CS

    更新日期:2014-12-01 00:00:00

  • Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum.

    abstract::Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque ...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Reynolds EC,Cai F,Shen P,Walker GD

    更新日期:2003-03-01 00:00:00

  • Use of bacteriophage-resistant mutants to study Actinomyces viscosus cell surface receptors.

    abstract::Spontaneously occurring bacteriophage-resistant mutants of Actinomyces viscosus were isolated. The mutants exhibited altered coaggregation patterns with streptococci. From analysis of the data, it appears that a cell surface structure on A. viscosus may function both as a phage receptor and as a binding site for co-ag...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Tylenda CA,Kolenbrander PE,Delisle AL

    更新日期:1983-11-01 00:00:00

  • Fibroblastic subpopulations in uninjured and wounded rabbit oral mucosa.

    abstract::Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Bronson RE,Treat JA,Bertolami CN

    更新日期:1989-01-01 00:00:00

  • Wavelength-independent microradiography: a method for non-destructive quantification of enamel and dentin mineral concentrations using polychromatic x-rays.

    abstract::Wavelength-independent Microradiography (WIM), described in this paper, used polychromatic, high-energy (less than or equal to 60 kV) x-rays for determination of mineral concentrations in tooth material non-destructively. This was done with the aid of a reference step-wedge made of 94% aluminum, 6% zinc. The mass atte...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Herkströter FM,Ten Bosch JJ

    更新日期:1990-08-01 00:00:00

  • Immunochemical identification and determination of proline-rich proteins in salivary secretions, enamel pellicle, and glandular tissue specimens.

    abstract::Acidic proline-rich proteins were localized histologically by means of the indirect immunoperoxidase technique in the acinar cells of parotid and submandibular gland sections of both man and Macaca fascicularis. These proteins were also identified as constituents of the long term in vivo-formed acquired pellicle on hu...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Kousvelari EE,Baratz RS,Burke B,Oppenheim FG

    更新日期:1980-08-01 00:00:00

  • Bone regeneration in defects compromised by radiotherapy.

    abstract::Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Hu WW,Ward BB,Wang Z,Krebsbach PH

    更新日期:2010-01-01 00:00:00

  • Experimental marginal leakage around dental amalgams placed in artificial cavities.

    abstract::Experimental marginal leakage of high- and low-Cu amalgam restorations placed in acrylic teeth, where the cavities were untreated or painted with denatured collagen and/or a CaP slurry, was assessed after specimens were stored in a 1% NaCl solution for ten days and for one yr. All specimens stored for ten days showed ...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Jodaikin A,Grossman ES

    更新日期:1984-08-01 00:00:00

  • Influence of an experimental sodium fluoride dentifrice on dental caries incidence in children.

    abstract::Schoolchildren residing in a fluoride-deficient area were provided either a sodium fluoride (0.1% F) or a nonfluoride dentifrice for home use. About half the children provided each type of dentifrice were also given an initial prophylaxis. Combining the data with regard to the type of dentifrice indicated that the sod...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章


    authors: Stookey GK,Beiswanger BB

    更新日期:1975-01-01 00:00:00

  • Mechanical work during stress-field translation in the human TMJ.

    abstract::The pathomechanics of degenerative joint disease of the temporomandibular joint (TMJ) may involve fatigue produced by mechanical work on the articulating tissues. This study tested the hypotheses that mechanical work in the TMJ (i) varies with the type of mandibular activity, and (ii) is evenly distributed over TMJ su...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Gallo LM,Chiaravalloti G,Iwasaki LR,Nickel JC,Palla S

    更新日期:2006-11-01 00:00:00

  • The relationship between oxide adherence and porcelain-metal bonding.

    abstract::The lack of a reliable bond test has hindered the elucidation of the mechanism for porcelain-metal bonding in dental systems, because a test capable of detecting differences among porcelain-metal bonds of various qualities is required before the reasons for these differences may be ascertained. A method was developed ...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Mackert JR Jr,Ringle RD,Parry EE,Evans AL,Fairhurst CW

    更新日期:1988-02-01 00:00:00

  • Lactoferrin: A Roadmap to the Borderland between Caries and Periodontal Disease.

    abstract::Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Levels of lactoferrin are consistently elevated in inflammatory diseases such as arthritis, inflammatory bowel diseases, corneal disease, and periodontitis. Single-nucleotide polymorphisms (SN...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审


    authors: Fine DH

    更新日期:2015-06-01 00:00:00

  • The release of elements of dental casting alloys into cell-culture medium.

    abstract::Ten dental casting alloys were tested for alloy-element release into cell-culture medium, and this release was related to alloy composition, alloy microstructure, and alloy cytotoxicity (previously determined). Cell-culture medium was analyzed for alloy elements by flame atomic absorption. Concentrations of elements i...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Wataha JC,Craig RG,Hanks CT

    更新日期:1991-06-01 00:00:00

  • Studies on microstructure of gold soldered joints.

    abstract::Solder microstructures were found to be influenced by those of the castings. A tendency of solder to match the microstructures contacted during its solidification was demonstrated. Several different types of defects were identified in the soldered joints. Tentative correlations of the observed microstructures and defe...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Saito T,Fortunato Santos J

    更新日期:1979-03-01 00:00:00

  • Topical Fluoride to Prevent Root Caries: Systematic Review with Network Meta-analysis.

    abstract::The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMe...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Zhang J,Sardana D,Li KY,Leung KCM,Lo ECM

    更新日期:2020-05-01 00:00:00

  • 4-META opaque resin--a new resin strongly adhesive to nickel-chromium alloy.

    abstract::1) A new adhesive opaque resin containing a reactive monomer, 4-methacryloxy-ethyl trimellitate anhydride (4-META), was prepared, and its application to thermosetting acrylic resin veneer crowns was studied. 2) The 4-META opaque resin was applied to a variety of nickel-chromium dental alloy specimens which had undergo...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Tanaka T,Nagata K,Takeyama M,Atsuta M,Nakabayashi N,Masuhara E

    更新日期:1981-09-01 00:00:00

  • Microstructures of duplex (beta + gamma) silver-tin alloys.

    abstract::The microstructures of (beta + gamma) silver-tin alloys are especially influenced by both homogenization temperature and subsequent heat treatment. When the alloy is cooled from homogenization temperatures above approximately 200 degrees C, lenticular regions of the ordered orthorhombic gamma phase precipitate from wi...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Abbott JR,Miller DR,Netherway DJ

    更新日期:1985-05-01 00:00:00

  • Cyclosporin a affects signaling events differentially in human gingival fibroblasts.

    abstract::Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). T...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Bostrom A,Bharath H,Saulewicz A,Narayanan AS

    更新日期:2005-06-01 00:00:00

  • An electrochemical study on the human dental enamel with special reference to isoelectric point.

    abstract::In an attempt to make a dynamic study of the isoelectric point and the chargeability of human dental enamel, an electrochemical approach was utilized. Zeta potential of three kinds of the enamel was measured by a streaming potential method. As a result, these isoelectric points could be decided. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Kambara M,Asai T,Kumasaki M,Konishi K

    更新日期:1978-02-01 00:00:00

  • LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4.

    abstract::Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this s...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Xing Q,de Vos P,Faas MM,Ye Q,Ren Y

    更新日期:2011-02-01 00:00:00

  • The growth hormone receptor gene is associated with mandibular height in a Chinese population.

    abstract::Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and singl...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Zhou J,Lu Y,Gao XH,Chen YC,Lu JJ,Bai YX,Shen Y,Wang BK

    更新日期:2005-11-01 00:00:00

  • Anatomic and directional variation in the mechanical properties of the mandibular condyle in pigs.

    abstract::Stereologic studies of trabecular architecture suggest that the pig mandibular condyle is strongest when loaded supero-inferiorly, and that stress is concentrated in the antero-inferior region (Teng and Herring, 1995). To test these hypotheses, we investigated the uni-axial mechanical properties of 22 pig mandibular c...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Teng S,Herring SW

    更新日期:1996-11-01 00:00:00

  • Adherence controlling elements in ceramic-metal systems. I. Precious alloys.

    abstract::Elemental analysis of two precious alloyceramic systems revealed the accumulation of Sn atoms within the interaction zone of couples subjected to a range of metal oxidation time; and varying total firing times. The source of Sn atoms which accumulated within the interaction zone was the opaque porcelain layer which co...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Anusavice KJ,Horner JA,Fairhurst CW

    更新日期:1977-09-01 00:00:00

  • The erupting first permanent molar--its place in stratified clinical field studies.

    abstract::Erupting first permanent molars of 5 1/2 to 6 1/2 year-olds are eminently suited for the clinical testing of potential caries-inhibiting techniques. Due to the rapid onset of caries in these teeth, accurate monitoring of new materials/regimes can be instituted and meaningful data obtained within one year of trial comm...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章


    authors: Stephen KW

    更新日期:1977-10-01 00:00:00

  • Effects of various resin composite (co)monomers and extracts on two caries-associated micro-organisms in vitro.

    abstract::Previous studies have shown that extracts of various filling materials, e.g., resin composites, may influence the growth of cariogenic micro-organisms. The purpose of this study was to examine the effects of important resin composite (co)monomers (Bis-GMA, UDMA, TEGDMA, EGDMA) and extracts of two commercial dental com...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Hansel C,Leyhausen G,Mai UE,Geurtsen W

    更新日期:1998-01-01 00:00:00

  • Methodological considerations concerning the use of Bruxcore Plates to evaluate nocturnal bruxism.

    abstract::The purpose of this study was to evaluate the Bruxcore Plate (BP) as a dependent measure of nocturnal bruxing activity. As part of a bruxism treatment study, we evaluated 100 nocturnal bruxers for bruxing activity before, during, and immediately after treatment and again at a six-month recall. The first 40 subjects wo...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Pierce CJ,Gale EN

    更新日期:1989-06-01 00:00:00

  • Enhancing oral health via sense of coherence: a cluster-randomized trial.

    abstract::Sense of coherence (SOC) has been related to oral health behaviors and oral-health-related quality of life (OHRQoL) in observational studies. This cluster-randomized trial aimed to test the effect of an intervention to enhance SOC on OHRQoL in children. Twelve primary schools were randomly allocated to intervention an...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验


    authors: Nammontri O,Robinson PG,Baker SR

    更新日期:2013-01-01 00:00:00

  • Inhibition and killing of oral bacteria by silver ions generated with low intensity direct current.

    abstract::Silver cations generated by passing low intensity direct current through pure silver electrodes were found to be sufficiently antibacterial to cause sterilization of samples of infected dentin. The optimal procedure involved a 5 microA current applied for 20 minutes with the anode then left in contact with the sample....

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Thibodeau EA,Handelman SL,Marquis RE

    更新日期:1978-09-01 00:00:00