Correlations of the expression of fibroblast growth factor-2, vascular endothelial growth factor, and their receptors with angiogenesis in synovial tissues from patients with internal derangement of the temporomandibular joint.

Abstract:

:Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the expression of FGF-2, VEGF, and their receptors-FGF receptor-1 (FGFR-1) and VEGF receptor-1 (Flt-1)-with microvessel density in synovial tissues of the TMJ. Using an immunohistochemical technique, we examined 47 joints (45 patients) with internal derangement. Individual microvessel density was evaluated by means of the CD34 antibody, a specific endothelial marker. The correlation between the percentage of immuno-positive cells and microvessel density was evaluated. In multiple logistic regression analysis, the correlation between the percentage of Flt-1-positive cells and microvessel density was significant [p = 0.005, odds ratio = 1.071, 95% confidence interval = 1.021-1.124]. These results suggest that the expression of the VEGF/Flt-1 system is involved in angiogenesis in inflamed synovial tissue in the TMJ.

journal_name

J Dent Res

authors

Sato J,Segami N,Yoshitake Y,Nishikawa K

doi

10.1177/154405910308200406

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

272-7

issue

4

eissn

0022-0345

issn

1544-0591

journal_volume

82

pub_type

杂志文章
  • HIV infection affects Streptococcus mutans levels, but not genotypes.

    abstract::We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034512454298

    authors: Liu G,Saxena D,Chen Z,Norman RG,Phelan JA,Laverty M,Fisch GS,Corby PM,Abrams W,Malamud D,Li Y

    更新日期:2012-09-01 00:00:00

  • Comparison of the reproducibility of EMG signals recorded from human masseter and lateral pterygoid muscles.

    abstract::EMG recordings of the left and right masseter and lateral pterygoid muscles were repeated three times in 15 young adults to test the reproducibility of the signals. Two tests were made on the same day (morning and afternoon) and one test three days later (morning). Needle and hook electrodes were used for the masseter...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650031401

    authors: Dahan J,Boitte C

    更新日期:1986-03-01 00:00:00

  • The formation of hydroxyapatite-ionomer cements at 38 degrees C.

    abstract::This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345940730030501

    authors: TenHuisen KS,Brown PW

    更新日期:1994-03-01 00:00:00

  • Intracrystalline structure of enamel crystals affected by caries.

    abstract::Enamel crystals in the demineralized zones in early caries lesions of human teeth were observed by high-resolution electron microscopy. The enamel crystals frequently exhibited perforations in their centers and defects of various sizes on their lateral surfaces. There were a number of small electron-lucent spots, sugg...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345870660110901

    authors: Tohda H,Takuma S,Tanaka N

    更新日期:1987-11-01 00:00:00

  • An involvement of trigeminal mesencephalic neurons in regulation of occlusal vertical dimension in the guinea pig.

    abstract::Although the occlusal vertical dimension (OVD) is strictly controlled, the neuronal mechanism of its regulation is still unclear. We hypothesize that neurons in the trigeminal mesencephalic nucleus (MesV) play an important role in the regulation of the OVD, because the MesV receives the projection from jaw-closing mus...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910308200715

    authors: Zhang W,Kobayashi M,Moritani M,Masuda Y,Dong J,Yagi T,Maeda T,Morimoto T

    更新日期:2003-07-01 00:00:00

  • Degradation, fatigue, and failure of resin dental composite materials.

    abstract::The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/154405910808700802

    authors: Drummond JL

    更新日期:2008-08-01 00:00:00

  • Acute-phase inflammatory response to periodontal disease in the US population.

    abstract::Moderate elevation of serum C-reactive protein (CRP) is a risk factor for cardiovascular disease among apparently healthy individuals, although factors that create this inflammatory response in the absence of systemic illness have not been clarified. This study aimed to: (1) evaluate associations among periodontal dis...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790010701

    authors: Slade GD,Offenbacher S,Beck JD,Heiss G,Pankow JS

    更新日期:2000-01-01 00:00:00

  • Limitations in bonding to dentin and experimental strategies to prevent bond degradation.

    abstract::The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine ca...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034510391799

    authors: Liu Y,Tjäderhane L,Breschi L,Mazzoni A,Li N,Mao J,Pashley DH,Tay FR

    更新日期:2011-08-01 00:00:00

  • Viral gene transfer to developing mouse salivary glands.

    abstract::Branching morphogenesis is essential for the formation of salivary glands, kidneys, lungs, and many other organs during development, but the mechanisms underlying this process are not adequately understood. Microarray and other gene expression methods have been powerful approaches for identifying candidate genes that ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034511429346

    authors: Hsu JC,Di Pasquale G,Harunaga JS,Onodera T,Hoffman MP,Chiorini JA,Yamada KM

    更新日期:2012-02-01 00:00:00

  • Preliminary observations on the effect of mantle field radiotherapy on salivary flow rates in patients with Hodgkin's disease.

    abstract::Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reduct...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345880670021801

    authors: Bucher JA,Fleming TJ,Fuller LM,Keene HJ

    更新日期:1988-02-01 00:00:00

  • Stem Cell-Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters.

    abstract::Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515600157

    authors: Maruyama CL,Leigh NJ,Nelson JW,McCall AD,Mellas RE,Lei P,Andreadis ST,Baker OJ

    更新日期:2015-11-01 00:00:00

  • Dental pulp cells for induced pluripotent stem cell banking.

    abstract::Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types of human cells are not easily accessible to minimally invasive procedures. Here we evaluated dental pulp cells (DPCs) as an optimal source of iPS cells, since they are easily obtained ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034510366846

    authors: Tamaoki N,Takahashi K,Tanaka T,Ichisaka T,Aoki H,Takeda-Kawaguchi T,Iida K,Kunisada T,Shibata T,Yamanaka S,Tezuka K

    更新日期:2010-08-01 00:00:00

  • Construction of a new fusion anti-caries DNA vaccine.

    abstract::Mutans streptococci (MS) are generally considered to be the principal etiological agent of dental caries. MS have two important virulence factors: cell- surface protein PAc and glucosyltransferases (GTFs). GTFs have two functional domains: an N-terminal catalytic sucrose-binding domain (CAT) and a C-terminal glucan-bi...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034509336727

    authors: Niu Y,Sun J,Fan M,Xu QA,Guo J,Jia R,Li Y

    更新日期:2009-05-01 00:00:00

  • Early detection of occlusal caries by measuring the electrical resistance of the tooth.

    abstract::The tooth resistance measuring instrument was compared to the traditional method of the explorer examination for the detection of occlusal carious lesions. The findings of the instrument were more sensitive as compared to the traditional method when verified by a histological examination. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570020801

    authors: White GE,Tsamtsouris A,Williams DL

    更新日期:1978-02-01 00:00:00

  • A pharmacokinetic and pharmacodynamic study of intravenous pilocarpine in humans.

    abstract::Pilocarpine (P) is of potential utility in the treatment of xerostomia. Because optimal development of P dosage forms for humans requires that its pharmacokinetics and pharmacodynamics be defined, this intravenous study of its disposition and associated salivary responses was performed. In a hospital setting, two heal...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章

    doi:10.1177/00220345950740120701

    authors: Tanzer JM,Kramer PA,Schulman P,Willard AK

    更新日期:1995-12-01 00:00:00

  • FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate.

    abstract::Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulat...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517750141

    authors: Xu J,Huang Z,Wang W,Tan X,Li H,Zhang Y,Tian W,Hu T,Chen YP

    更新日期:2018-05-01 00:00:00

  • Autophagy Modulates Cell Mineralization on Fluorapatite-Modified Scaffolds.

    abstract::As a major intracellular degradation and recycling machinery, autophagy plays an important role in maintaining cellular homeostasis and remodeling during normal development. Our previous study showed that fluorapatite (FA) crystal-coated electrospun polycaprolactone (PCL) was capable of inducing differentiation and mi...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516636852

    authors: Li Y,Guo T,Zhang Z,Yao Y,Chang S,Nör JE,Clarkson BH,Ni L,Liu J

    更新日期:2016-06-01 00:00:00

  • Orthodontic Force Induces Systemic Inflammatory Monocyte Responses.

    abstract::Periodontal inflammation and alveolar bone remodeling during orthodontic tooth movement are considered regional reactions. However, how systemic immune responses are involved in this regional reaction remains unclear. In this study, we explored the systemic effects of orthodontic force by focusing on the mononuclear p...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515592868

    authors: Zeng M,Kou X,Yang R,Liu D,Wang X,Song Y,Zhang J,Yan Y,Liu F,He D,Gan Y,Zhou Y

    更新日期:2015-09-01 00:00:00

  • Genetic Polymorphisms in FGFR2 Underlie Skeletal Malocclusion.

    abstract::Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519872951

    authors: Jiang Q,Mei L,Zou Y,Ding Q,Cannon RD,Chen H,Li H

    更新日期:2019-11-01 00:00:00

  • Topical Fluoride to Prevent Root Caries: Systematic Review with Network Meta-analysis.

    abstract::The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMe...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034520906384

    authors: Zhang J,Sardana D,Li KY,Leung KCM,Lo ECM

    更新日期:2020-05-01 00:00:00

  • PTH and Vitamin D Repress DMP1 in Cementoblasts.

    abstract::A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515599726

    authors: Wang L,Tran AB,Nociti FH Jr,Thumbigere-Math V,Foster BL,Krieger CC,Kantovitz KR,Novince CM,Koh AJ,McCauley LK,Somerman MJ

    更新日期:2015-10-01 00:00:00

  • Polymerizable amines as promoters of cold-curing resins and composites.

    abstract::The accelerating activity of N,N-substituted aminoethyl methacrylates on the curing of methyl methacrylate and composite resins with benzoyl peroxide is somewhat smaller than that of dimethyl-p-toluidine. Tesins cured with aminoethyl methacrylates containing a p-tolyl and 3,5-xylyl substituent on the nitrogen atom tur...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345750540041301

    authors: Dneboský J,Hynková V,Hrabák F

    更新日期:1975-07-01 00:00:00

  • Food-holding and -biting behavior in human subjects lacking periodontal receptors.

    abstract::Previous studies have suggested that information provided by periodontal mechanoreceptors is particularly important for the fine motor control of the mandible, i.e., when humans hold and carefully manipulate food particles between the teeth with low biting forces. In the present study, we further evaluated this hypoth...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345980770041001

    authors: Trulsson M,Gunne HS

    更新日期:1998-04-01 00:00:00

  • The Ca, Pi, F, and proline content of developing bovine enamel under GBHA-stained and unstained bands.

    abstract::The surface enamel of fetal bovine teeth was stained with GBHA to indicate the position of bands of smooth-ended and ruffle-ended ameloblasts relative to the developing enamel. The boundaries of the bands were scored, under a dissecting microscope, and the bulk enamel under each band was collected. The enamel samples ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345880670060901

    authors: Bawden JW,Keels MA,Deaton TG,Crenshaw MA

    更新日期:1988-06-01 00:00:00

  • Impact of Age on Disease Progression and Microenvironment in Oral Cancer.

    abstract::Despite the recognized link between aging and cancer, most preclinical studies in experimental tumor models are conducted with 6- to 8-wk-old rodents. The goal of the present study was to examine the impact of age on tumor incidence, growth, and microenvironmental characteristics in mouse models of head and neck squam...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034518775736

    authors: Vincent-Chong VK,DeJong H,Rich LJ,Patti A,Merzianu M,Hershberger PA,Seshadri M

    更新日期:2018-10-01 00:00:00

  • Composition of Mineral Produced by Dental Mesenchymal Stem Cells.

    abstract::Mesenchymal stem cells isolated from different dental tissues have been described to have osteogenic/odontogenic-like differentiation capacity, but little attention has been paid to the biochemical composition of the material that each produces. Here, we used Raman spectroscopy to analyze the mineralized materials pro...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515599765

    authors: Volponi AA,Gentleman E,Fatscher R,Pang YW,Gentleman MM,Sharpe PT

    更新日期:2015-11-01 00:00:00

  • Effect of pH on the growth and proteolytic activity of Porphyromonas gingivalis and Bacteroides intermedius.

    abstract::The effect of pH on the growth and proteolytic activity of the type strain and fresh isolates of Porphyromonas gingivalis and Bacteroides intermedius was investigated. B. intermedius strains grew with and without glucose at a pH as low as 5.0. These bacteria grew almost as well as Streptococcus mutans at pH 5.0 and be...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345900690060801

    authors: Takahashi N,Schachtele CF

    更新日期:1990-06-01 00:00:00

  • Lysozyme-mediated de-chaining of Streptococcus mutans and its antibacterial significance in an acidic environment.

    abstract::The ability of physiological amounts of lysozyme to de-chain two serotype c strains of Streptococcus mutans was determined. Both human and hen lysozymes were equally effective in chain breakage of S. mutans DPR and S. mutans DJR. De-chaining did not affect growth of cultures, but resulted in finely dispersed suspensio...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345850640010901

    authors: Iacono VJ,Byrnes TP,Crawford IT,Grossbard BL,Pollock JJ,MacKay BJ

    更新日期:1985-01-01 00:00:00

  • Masticatory force and function in patients with hemispheric brain infarction and hemiplegia.

    abstract::Recent functional animal studies have reported that the motor control of masticatory muscle function is bilaterally guided by both hemispheres, which may fundamentally differ from the cortical control of limb muscle function. In this study, we investigated whether unilateral cortical brain infarction induces different...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780120701

    authors: Kemppainen P,Waltimo A,Palomäki H,Salonen O,Könönen M,Kaste M

    更新日期:1999-12-01 00:00:00

  • The surface free energy of oral streptococci after being coated with saliva and its relation to adhesion in the mouth.

    abstract::Contact angle measurements on layers of bacteria were used to determine the bacterial surface free energy (gamma b) of a variety of oral streptococcal strains, both without and after being coated with human whole saliva. At least four isolates of each species, either freshly isolated or laboratory strains, were used. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345850640100501

    authors: Weerkamp AH,van der Mei HC,Busscher HJ

    更新日期:1985-10-01 00:00:00