Abstract：
:Despite the recognized link between aging and cancer, most preclinical studies in experimental tumor models are conducted with 6- to 8-wk-old rodents. The goal of the present study was to examine the impact of age on tumor incidence, growth, and microenvironmental characteristics in mouse models of head and neck squamous cell carcinoma (HNSCC). Experimental studies were conducted with the 4-nitroquinoline-oxide (4NQO) oral carcinogenesis model and orthotopic FaDu HNSCC xenografts, established in young (7 to 12 wk of age) and old (65 to 70 wk of age) female C57BL/6 mice ( n = 44; 4NQO model) and severe combined immunodeficient mice ( n = 13; HNSCC xenografts). Noninvasive whole body magnetic resonance imaging revealed increased subcutaneous and visceral fat in aging animals of both strains. On histologic examination, a higher incidence ( P < 0.001) of severe dysplasia/invasive squamous cell carcinoma was observed in old mice (92%) as compared with young mice (69%). Old C57BL/6 mice exposed to 4NQO exhibited increased incidence of oral and extraoral (peritoneal masses) neoplasms (42%) versus their young counterparts ( P < 0.05). The incidence of extraoral neoplasms was significantly lower (16%) in the younger cohort. Interestingly, no difference in growth rate and oxygen saturation was observed between orthotopic FaDu xenografts established in old and young severe combined immunodeficient mice. Our observations suggest that host age may have an impact on the growth kinetics and progression of HNSCC in the immunocompetent 4NQO model. Further investigation into the impact of aging on tumor response to preventive and therapeutic intervention is warranted.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Vincent-Chong VK,DeJong H,Rich LJ,Patti A,Merzianu M,Hershberger PA,Seshadri Mdoi
10.1177/0022034518775736subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1268-1276issue
11eissn
0022-0345issn
1544-0591journal_volume
97pub_type
杂志文章abstract：:Recent studies have shown that the extent of hydrolysis by plaque of the trypsin substrate, N-benzoyl-DL-arginine-2-naphthylamide (BANA), correlates with the numbers and proportions of spirochetes in subgingival plaque samples, and appears to be an indicator of clinical disease. In this study, BANA hydrolysis by subgi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670121201
更新日期：1988-12-01 00:00:00
abstract：:Cleidocranial dysplasia (CCD) is a skeletal dysplasia caused by heterozygous mutations of RUNX2, a gene that is essential for the mineralization of bone and tooth. We isolated primary dental pulp cells from a 10-y-old patient and tested their proliferative capacity, alkaline phosphatase activity, and ability to form m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514566655
更新日期：2015-04-01 00:00:00
abstract：:Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650071601
更新日期：1986-07-01 00:00:00
abstract：:Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis usin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511423394
更新日期：2011-12-01 00:00:00
abstract：:Damage to the dentin matrix investigates the proliferation and mobilization of dental progenitor cells to the injury site, the mechanisms of which are not defined. EphB receptors and ephrin-B ligands expressed within the perivascular niche of dental pulp have been implicated following tooth injury. We propose that ele...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509342363
更新日期：2009-09-01 00:00:00
abstract：:This case-control study evaluated the association of headache and other co-morbid pain with temporomandibular disorder (TMD) pain in adolescents and explored the temporal co-variance of headache and TMD pain. In a population-based sample of 12- to 19-year-olds, 350 patients with self-reported TMD pain and 350 healthy ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513496255
更新日期：2013-09-01 00:00:00
abstract：:Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis). The severity of dental fluorosis is also dependent upon fluoride dose and the timing and duration of fluoride exposure. ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034510384626
更新日期：2011-05-01 00:00:00
abstract：:Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different from that of the skin, the mechanisms underlying injured pain of the oral mucosa remain poorly understood. The transient r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514565645
更新日期：2015-03-01 00:00:00
abstract：:Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable of withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism by which inflamed odontoblasts are protected fro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519869580
更新日期：2019-10-01 00:00:00
abstract：:Early childhood caries (ECC) is a chronic disease affecting the oral health of children globally. This disease is multifactorial, but a primary factor is cariogenic microorganisms such as Streptococcus mutans. Biosynthetic gene clusters (BGCs) encode small molecules with diverse biological activities that influence th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520914519
更新日期：2020-07-01 00:00:00
abstract：:The synthesis of many polycarboxylic acids is reported. An account is given of their stability in aqueous solution and the properties of cements formed by their reaction with ion-leachable glasses. A copolymer of acrylic and itaconic acids was found to combine several favorable characteristics. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590060801
更新日期：1980-06-01 00:00:00
abstract：:The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501205
更新日期：2006-12-01 00:00:00
abstract：:Dynamic changes of pulpal blood flow (PBF) and gingival blood flow (GBF) induced by intra-venous injection of two kinds of vasoactive drugs were observed in dogs by means of Laser Doppler Velocimetry. Intra-venous injection of norepinephrine caused PBF to increase, corresponding to the blood pressure (BP) increase, wh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680050701
更新日期：1989-05-01 00:00:00
abstract：:Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514565647
更新日期：2015-03-01 00:00:00
abstract：:Previous studies have shown that therapeutic pulsed ultrasound (pulsed) has superior stimulatory effect on bone fracture healing compared with continuous ultrasound (continuous). Our predictive hypothesis was that pulsed ultrasound can produce better bone formation during mandibular osteodistraction than continuous ul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808701018
更新日期：2008-10-01 00:00:00
abstract：:Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on the tooth surface. Increased periodontal disease is associated with aging. We investigated the effect of aging on challenge by oral pathogens, examining the host response, colonization, and osteoclast numbers in aged versus young mice. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625962
更新日期：2016-04-01 00:00:00
abstract：:Pilocarpine (P) is of potential utility in the treatment of xerostomia. Because optimal development of P dosage forms for humans requires that its pharmacokinetics and pharmacodynamics be defined, this intravenous study of its disposition and associated salivary responses was performed. In a hospital setting, two heal...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345950740120701
更新日期：1995-12-01 00:00:00
abstract：:A model system consisting of vacuum-deposited aluminum on glass was developed to demonstrate the effectiveness of cavitational activity (occurring within the cooling water supply of a dental ultrasonic scaler) in the removal of particulate material from solid surfaces. The amount of solid material removed from the mod...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630091401
更新日期：1984-09-01 00:00:00
abstract：:The synchronized cyrstal dissolution hypothesis previously proposed to explain the unusual dissolution behavior of human dental enamel and hydroxyapatite in partially saturated acidic media has been critically examined with dissolution-dialysis transport experiments. The findings are in accord with the hypothesis. A m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560040701
更新日期：1977-04-01 00:00:00
abstract：:Obesity is a widespread chronic inflammatory disorder characterized by an increased overall disease burden and significant association with periodontitis. The aim of this prospective clinical cohort study was to investigate the effect of obesity on orthodontic tooth movement. Fifty-five adolescent patients (27 males, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516688448
更新日期：2017-05-01 00:00:00
abstract：:The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues. We have improved tooth bioengineering methods by comparing the utility of cultured rat tooth bud cells obtained from three- to seven-day post-natal (dpn) rats for to...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300703
更新日期：2004-07-01 00:00:00
abstract：:Bacteria attach to teeth and oral mucosal surfaces in a surprisingly selective manner, and attachment appears to be the first step in the colonization process. Attachment is thought to involve lectin-like and/or hydrophobic ligands, called adhesins, often present in bacterial surface appendages which interact with rec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630030401
更新日期：1984-03-01 00:00:00
abstract：:Clinical studies have shown that metabolic syndrome (MetS) is associated with increased risk of developing periodontitis. However, the underlying mechanisms remain largely unknown. Since it is known that lipopolysaccharide (LPS)-activated toll-like receptor 4 signaling pathways play a crucial role in periodontitis, we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514561658
更新日期：2015-02-01 00:00:00
abstract：:The flexure moduli of elasticity of solid and multi-stranded orthodontic wires were determined. Results for the solid wires approximated their tensile values, but the differences were statistically significant for the stainless steel, chromium-cobalt-nickel, and nickel-titanium alloys. The flexure moduli of the multi-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620072201
更新日期：1983-07-01 00:00:00
abstract：:Investigations of the maturation pattern of rat incisor enamel by quantitative electron microscopy and electron-probe microanalysis indicate that mineralization of rat enamel can be regarded, as in humans, as a regular and progressive process pattern of enamel matrix formation. The species variations that have been pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580024201
更新日期：1979-03-01 00:00:00
abstract：:The periodontium contains heterogeneous mesenchymal cell populations with various differentiation potentials. The capacity of these cells for tissue formation as well as the origin of their precursors are still not entirely defined. In this study, cells originating from different periodontal tissues were cultured in v...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740051201
更新日期：1995-05-01 00:00:00
abstract：:Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in mai...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517707512
更新日期：2017-07-01 00:00:00
abstract：:As an approach for improving the outcome and predictability of periodontal regenerative therapies, we have focused on determining the responses of cells within the local environment to putative regenerative factors. This study examined the effects of bone morphogenetic protein-2 (BMP-2) on murine cementoblasts in vitr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200106
更新日期：2003-01-01 00:00:00
abstract：:Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regenerati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517691507
更新日期：2017-05-01 00:00:00
abstract：:Caregivers' health literacy has emerged as an important determinant of young children's health care and outcomes. We examined the hypothesis that caregivers' health literacy influences children's oral-health-care-related expenditures. This was a prospective cohort study of 1,132 child/caregiver dyads (children's mean ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513484335
更新日期：2013-07-01 00:00:00
