Abstract:
:Periodontal inflammation and alveolar bone remodeling during orthodontic tooth movement are considered regional reactions. However, how systemic immune responses are involved in this regional reaction remains unclear. In this study, we explored the systemic effects of orthodontic force by focusing on the mononuclear phagocyte system. Flow cytometric analysis showed that the percentage of inflammatory monocytes, in peripheral blood and in the monocyte reservoir spleen, decreased on days 1 and 3 and then recovered on day 7 after force application. Along with the systemic decrease of inflammatory monocyte percentage, the number of tartrate-resistant acid phosphatase-positive osteoclasts increased in the compression side of the periodontal tissue during orthodontic tooth movement. Systemic transfusion of enhanced green fluorescent protein-labeled inflammatory monocytes showed recruitment of these monocytes to the orthodontic force compression side of periodontal tissues. These monocytes were colocalized with tartrate-resistant acid phosphatase-positive osteoclasts. In vivo and in vitro experiments showed that orthodontic force could upregulate the expression of pivotal monocyte chemokine monocyte chemotactic protein 1 in periodontal tissues or cultured periodontal ligament cells, which may contribute to monocyte recruitment to regional sites. These data suggest that orthodontic force induces systemic immune responses related to inflammatory monocytes and that systemic inflammatory monocytes can be recruited to periodontal tissues by orthodontic force stimulus.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Zeng M,Kou X,Yang R,Liu D,Wang X,Song Y,Zhang J,Yan Y,Liu F,He D,Gan Y,Zhou Ydoi
10.1177/0022034515592868subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1295-302issue
9eissn
0022-0345issn
1544-0591pii
0022034515592868journal_volume
94pub_type
杂志文章abstract::The present investigation demonstrates that direct application of a composite resin on an acid-etched, vital dentin surface is hazardous to the pulp in monkey teeth. This indicates that exposed dentin should be protected before treating the tooth with a restorative technique including acid etching. A ca(OH)2-containin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022001
更新日期:1976-03-01 00:00:00
abstract::During porcelainization the non-preoxidized alloy develops a Be-rich reaction zone in the interface which separates a Be-depleted alloy from a Li and (to a lesser extent Na) depleted region of the ceramic. Thus, Be diffuses to the interface through the alloy Be degrees leads to Be++ + 2 e- occurs at the interface; som...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570021501
更新日期:1978-02-01 00:00:00
abstract::Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to exami...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600105
更新日期:2007-01-01 00:00:00
abstract::The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508400409
更新日期:2005-04-01 00:00:00
abstract::Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their derm...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750060601
更新日期:1996-06-01 00:00:00
abstract::Pulpal blood flow was determined in 32 dogs ranging in age from 6 weeks to 18 months by the isotope fractionation method incorporating diffusible and nondiffusible tracers. Dogs were placed into selected age groups by the developmental status of the canine teeth. For the teeth sampled, the maxillary first, second, and...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560102601
更新日期:1977-10-01 00:00:00
abstract::Previous research, in which the bonding effectiveness of the 3 self-etch monomers HAEPA, EAEPA, and MAEPA was determined, showed that MAEPA was most effective. In this study, the molecular interactions of these monomers with hydroxyapatite and dentin were investigated by combining x-ray diffraction, infrared spectrosc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510397197
更新日期:2011-05-01 00:00:00
abstract::This paper discusses loosely bound fluoride and its role in dental caries and prevention. Loosely bound fluoride (abbr. by Fa) is fluoride adsorbed onto enamel mineral crystallites. Several recent studies indicate that a high total level of fluoride in enamel does not guarantee protection against caries. This leads to...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345900690S118
更新日期:1990-02-01 00:00:00
abstract::The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives. In many cases, pre-conditioning the restoratives in these liquids for one week produced swelling of the polymer matrix and considerable surface damage. The result...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640111601
更新日期:1985-11-01 00:00:00
abstract::Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520906793
更新日期:2020-05-01 00:00:00
abstract::Composite resin restorations in cavities are generally associated with the development of a contraction gap during the first minutes after insertion. Enamel-Bond-Concise composite restoration were placed on both approximal sides of extracted pre-molars. The cervical walls of all cavities extended beyond the enamel-cem...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630051501
更新日期:1984-05-01 00:00:00
abstract::Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650071601
更新日期:1986-07-01 00:00:00
abstract::Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal def...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700708
更新日期:2008-07-01 00:00:00
abstract::A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515599726
更新日期:2015-10-01 00:00:00
abstract::Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780061001
更新日期:1999-06-01 00:00:00
abstract::Van der Woude syndrome (VWS) is an autosomal-dominant oral facial disorder. To find a gene mutation in a Japanese family using fingernail DNA samples, we performed this study. We hypothesized that a gene mutation in IRF6 might be involved in VWS, and that fingernail DNA samples may be valuable for detecting such mutat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501215
更新日期:2006-12-01 00:00:00
abstract::Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regenerati...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517691507
更新日期:2017-05-01 00:00:00
abstract::Masticatory muscle silent periods were compared in normal subjects and in patients with MPD syndrome before and after a variety of psychological, physiological, and pharmacological forms of therapy. All patients initially showed prolonged silent periods in one or more of the muscles. There was a direct relationship be...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600030501
更新日期:1981-03-01 00:00:00
abstract::We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean Na...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518814829
更新日期:2019-02-01 00:00:00
abstract::Enamel abraders used in two-body wear tests suffer the disadvantage that standardization is difficult or impossible to obtain. The aim of this study was to test whether steatite (a ceramic material with a Vickers Hardness similar to that of enamel) could be used as a satisfactory human enamel analogue. The friction an...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730091001
更新日期:1994-09-01 00:00:00
abstract::Candida albicans is an opportunistic fungal organism frequently detected in the oral cavity of children with severe early childhood caries (S-ECC). Previous studies suggested the cariogenic potential of C. albicans, in vitro and in vivo, and further demonstrated its synergistic interactions with Streptococcus mutans. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518790941
更新日期:2018-12-01 00:00:00
abstract::We conducted a school-based parallel cluster randomized controlled trial with 36-month follow-up of children aged 7 to 8 years. Primary schools were randomly assigned to 2 groups: 3 applications of fluoride varnish (22,600 ppm) each year or no intervention. The primary outcome was DFS increment in the first permanent ...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034511422063
更新日期:2011-11-01 00:00:00
abstract::Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660s108
更新日期:1987-02-01 00:00:00
abstract::The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501205
更新日期:2006-12-01 00:00:00
abstract::Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated os...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514557672
更新日期:2015-01-01 00:00:00
abstract::The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512474668
更新日期:2013-03-01 00:00:00
abstract::The effects of various additives on the setting of the glass-ionomer cement system was studied by means of cone and plate viscometry. The action of (+)-tartaric acid, the most important additive, on the setting reaction depended on its concentration. Low concentrations accelerated the development of viscosity of the c...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670120101
更新日期:1988-12-01 00:00:00
abstract::Impacted human third molar teeth were examined, both with the light and electron microscope, to determine the extent of the odontoblast process. The odontoblast process was found to be limited to the inner third of coronal dentin and inner half of mid-root dentin. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/002203457905800412011
更新日期:1979-11-01 00:00:00
abstract::Streptococcus mutans strain JH1005 is a mutant that produces levels of bacteriocin activity three-fold-elevated than those produced by its parent, JH1001. A single infection regimen with JH1005 was found to result in persistent colonization of the teeth of all three adult subjects tested. This is a significant improve...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660060101
更新日期:1987-06-01 00:00:00