Abstract：
:We conducted a school-based parallel cluster randomized controlled trial with 36-month follow-up of children aged 7 to 8 years. Primary schools were randomly assigned to 2 groups: 3 applications of fluoride varnish (22,600 ppm) each year or no intervention. The primary outcome was DFS increment in the first permanent molars, with the hypothesis that 9 applications of varnish over 3 years would result in a lower increment in the test group. Follow-up measurements were recorded by examiners blind to the allocation. Ninety-five schools were randomized to the test and 95 to the reference groups; 1473 (test) and 1494 (reference) children participated in the trial. An intention-to-treat analysis was carried out with random effects models. The DFS increment was 0.65 (SD 2.15) in the test and 0.67 (SD 2.10) in the reference groups, respectively. There was no statistically significant difference between the groups. We were unable to demonstrate an effect for fluoride varnish when it was used as a public health intervention to prevent caries in the first permanent molar teeth (Inter-national Standard Randomized Controlled Trial Registration: ISRCTN: #72589426).
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Milsom KM,Blinkhorn AS,Walsh T,Worthington HV,Kearney-Mitchell P,Whitehead H,Tickle Mdoi
10.1177/0022034511422063subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1306-11issue
11eissn
0022-0345issn
1544-0591pii
0022034511422063journal_volume
90pub_type
杂志文章,随机对照试验abstract：:The sequelae of sustained, in vivo delivery of two important neurotransmitter substances, glutamate and thyrotropin-releasing hormone (TRH), upon craniofacial growth and development have previously not been investigated. Our purpose was to document and compare the relative effects of glutamate and TRH microspheres ste...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760080601
更新日期：1997-08-01 00:00:00
abstract：:The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512474668
更新日期：2013-03-01 00:00:00
abstract：:Samples of a base mental alloy were cast and welded together using a conventional welding procedure. The joints were loaded and placed either in a corrosive environment or in air for varying time periods. The tensile and shear strength of the joints was unaffected by the corrosive environment, and the joints, despite ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600021101
更新日期：1981-02-01 00:00:00
abstract：:Proteolytic hydrolysis of casein and porcine or bovine glycoproteins by S mutans was demonstrated in the present study. Caseinolytic activity was found in both the soluble contents of the cells and the cellular debris after rupture of the cells. However, caseinolytic activity could not be demonstrated after growth in ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550031701
更新日期：1976-05-01 00:00:00
abstract：:Adhesion of restorative and protective materials to dentin is an important requirement for operative and preventive dentistry. Wettability and roughness are dentin substrate conditions that are critical to establishing good adhesion. This study examined superficial and deep dentin for variations in water contact angle...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780091001
更新日期：1999-09-01 00:00:00
abstract：:We determined the exposure to mercury from dental amalgam by comparison of blood levels of mercury before and after removal of all amalgams from ten subjects. Baseline concentrations of mercury in whole blood were measured weekly for four to 18 weeks (median = 6.6 weeks) prior to removal. All amalgams were removed in ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680050501
更新日期：1989-05-01 00:00:00
abstract：:TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514530164
更新日期：2014-06-01 00:00:00
abstract：:It has not been established whether transmission of mutans streptococci occurs between unrelated children older than 4 years of age. The aim of the study was to investigate the possible transmission of mutans streptococci genotypes from child to child in kindergarten. We studied 96 children (ages 5-6 yrs) in three San...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509353400
更新日期：2010-01-01 00:00:00
abstract：:Medication-related osteonecrosis of the jaw (MRONJ), although initially believed to be exclusively associated with bisphosphonates, has been implicated in recent reports with additional drugs, especially the bone antiresorptive denosumab. The pathophysiology has not been fully elucidated, and no causal association bet...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515572021
更新日期：2015-04-01 00:00:00
abstract：:Information on the time-dependent release of fluoride from filled resins containing fluoride particles as a function of particle content and solution pH is limited. This study characterized the fluoride ion release from filled resins containing CaF2 particles as a function of filler content and pH. Urethane dimethacry...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400508
更新日期：2005-05-01 00:00:00
abstract：:Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610091301
更新日期：1982-09-01 00:00:00
abstract：:In this study, the differences in lesion remineralization and fluoride uptake after brushing with a 300 ppm F or a 1000 ppm F dentifrice (as NaF) were investigated. Twenty volunteers with partial dentures in their lower jaws were divided into two groups. Bovine enamel slabs with artificial lesions were mounted in the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650120601
更新日期：1986-12-01 00:00:00
abstract：:Experiments were performed to determine the role of the immune response in rat periodontal disease. Germ-free rats were fed defined antigen-free liquid diets or a diet containing ovalbumin(OVA) as a prototype antigen. The OVA-fed rats demonstrated increased gingival lymphocytes (mainly T at early times), OVA-sensitize...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630031801
更新日期：1984-03-01 00:00:00
abstract：:A gravity sintering fabrication technique has been developed for producing Co-Cr-Mo alloy dental implants having a porous coating on the root portion. This process allows for control of pore structure enabling ingrowth of either bone or fibrous tissue. The microstructure and mechanical properties of these materials ha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560050501
更新日期：1977-05-01 00:00:00
abstract：:Since edentate subjects have a reduced masticatory function, it can be expected that the morphology of the cancellous bone of their mandibular condyles has changed according to the altered mechanical environment. In the present study, the morphology of cylindrical cancellous bone specimens of the mandibular condyles o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300314
更新日期：2004-03-01 00:00:00
abstract：:In previous studies, light-cured glass-ionomer cements have been shown to evoke cytotoxic reactions. It was the purpose of this investigation (a) to determine the nature of the ingredients released into an aqueous medium from 2 light-cured glass-ionomer cements (GICs) and 3 compomers; (b) to evaluate the cytotoxicity ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770121001
更新日期：1998-12-01 00:00:00
abstract：:Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519885362
更新日期：2020-01-01 00:00:00
abstract：:Adhesive bonding of resins to dentin surfaces requires the removal of the layer of debris caused by the cutting. Certain isotonic acidic solutions can do this rapidly. Five solutions were evaluated using cell cultures and pulp studies in monkeys. At concentrations above 10%, each solution caused the cultured human epi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610081001
更新日期：1982-08-01 00:00:00
abstract：:Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808701210
更新日期：2008-12-01 00:00:00
abstract：:Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis usin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511423394
更新日期：2011-12-01 00:00:00
abstract：:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520952031
更新日期：2021-01-01 00:00:00
abstract：:Two series of dental composites, along with the unfilled resin matrix, were examined to determine the effects of filler level and size on selected properties. Both series were prepared by incorporating a silanated barium borosilicate filler into a visible-light-activated polyphenylene polymethacrylate resin matrix. On...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121501
更新日期：1985-12-01 00:00:00
abstract：:Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on the tooth surface. Increased periodontal disease is associated with aging. We investigated the effect of aging on challenge by oral pathogens, examining the host response, colonization, and osteoclast numbers in aged versus young mice. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625962
更新日期：2016-04-01 00:00:00
abstract：:Stress-relaxation measurements were performed on specimens of radicular human dentin. The relaxation modulus showed a linear dependence on the logarithm of time and the approximation to the logarithmic distribution function of relaxation times was used to predict the behavior of other viscoelastic properties. This exp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540061801
更新日期：1975-11-01 00:00:00
abstract：:The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin phosphophoryn (DPP). DPP appears to be synthesized as a part of a larger compound protein, dentin sialophosphoprotein (DSPP). DSPP has never been isolated or detected in dentin extracts. It is now evident that DSPP is a chime...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513516631
更新日期：2014-02-01 00:00:00
abstract：:Previous studies have shown that extracts of various filling materials, e.g., resin composites, may influence the growth of cariogenic micro-organisms. The purpose of this study was to examine the effects of important resin composite (co)monomers (Bis-GMA, UDMA, TEGDMA, EGDMA) and extracts of two commercial dental com...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770010601
更新日期：1998-01-01 00:00:00
abstract：:Interfacial bonding and stability of gamma-methacryloxypropyltrimethoxysilane with silica surfaces have been studied by means of infrared spectroscopy. The addition of n-propylamine enhances silanization of gamma-methacryloxypropyltrimethoxysilane to silica surfaces in normal aliphatic hydrocarbons, and cyclohexane yi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610121301
更新日期：1982-12-01 00:00:00
abstract：:Sealants are highly effective in preventing dental caries in the pits and fissures of teeth when applied by trained operators in clinical trials and public health programs. The effectiveness of fissure sealants when applied in dental practices is still not known. The purpose of this longitudinal study was to evaluate ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345950740091301
更新日期：1995-09-01 00:00:00
abstract：:The purpose of this study was to determine the role of saliva-derived biomarkers and periodontal pathogens during periodontal disease progression (PDP). One hundred human participants were recruited into a 12-month investigation. They were seen bi-monthly for saliva and clinical measures and bi-annually for subtractio...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/0022034511399908
更新日期：2011-06-01 00:00:00
abstract：:Dendritic cells, such as Langerhans cells (LC), in different ectodermal compartments may have different functional capabilities. The present study was undertaken to compare oral Langerhans cells (LC) with those of the epidermis in terms of their ability to co-stimulate T-cells in vitro. A Mixed Epithelial Cell Lymphoc...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780030701
更新日期：1999-03-01 00:00:00
