Abstract：
:Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on the tooth surface. Increased periodontal disease is associated with aging. We investigated the effect of aging on challenge by oral pathogens, examining the host response, colonization, and osteoclast numbers in aged versus young mice. We also compared the results with mice with lineage-specific deletion of the transcription factor FOXO1, which reduces dendritic cell (DC) function. Periodontitis was induced by oral inoculation of Porphyromonas gingivalis and Fusobacterium nucleatum in young (4 to 5 mo) and aged (14 to 15 mo) mice. Aged mice as well as mice with reduced DC function had decreased numbers of DCs in lymph nodes, indicative of a diminished host response. In vitro studies suggest that reduced DC numbers in lymph nodes of aged mice may involve the effect of advanced glycation end products on DC migration. Surprisingly, aged mice but not mice with genetically altered DC function had greater production of antibody to P. gingivalis, greater IL-12 expression, and more plasma cells in lymph nodes following oral inoculation as compared with young mice. The greater adaptive immune response in aged versus young mice was linked to enhanced levels of P. gingivalis and reduced bacterial diversity. Thus, reduced bacterial diversity in aged mice may contribute to increased P. gingivalis colonization following inoculation and increased periodontal disease susceptibility, reflected by higher TNF levels and osteoclast numbers in the periodontium of aged versus young mice.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Wu Y,Dong G,Xiao W,Xiao E,Miao F,Syverson A,Missaghian N,Vafa R,Cabrera-Ortega AA,Rossa C Jr,Graves DTdoi
10.1177/0022034515625962subject
Has Abstractpub_date
2016-04-01 00:00:00pages
460-6issue
4eissn
0022-0345issn
1544-0591pii
0022034515625962journal_volume
95pub_type
杂志文章abstract：UNLABELLED:We have previously shown that the resin monomer 2-hydroxyethylmethacrylate (HEMA) affects mouse B-lymphocyte activity, leading to increased IgG1 antibody production in vivo. In the present study, we tested, in vitro, the hypothesis that HEMA also affects human B-lymphocyte activity. The in vitro production o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510378522
更新日期：2010-12-01 00:00:00
abstract：:Bifidobacteria are aciduric bacteria that might play a role in the caries process. To test the hypothesis that Bifidobacteria behave as caries-associated organisms, as predicted by the ecological plaque hypothesis, we determined salivary levels of Bifidobacteria and caries-associated organisms for 156 older adults. Sa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510369319
更新日期：2010-09-01 00:00:00
abstract：:Cultures of Streptococcus mutans MFe28 (serotype h) were grown with differing extracellular polysaccharide (EPS) content. Biochemical and physicochemical characteristics considered relevant to caries were measured. Acid production parameters measured in a pH-stat were: Vm = 0.76 +/- 0.14 mumol/g/sec (wet weight); appa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060101
更新日期：1988-06-01 00:00:00
abstract：:Proteolytic hydrolysis of casein and porcine or bovine glycoproteins by S mutans was demonstrated in the present study. Caseinolytic activity was found in both the soluble contents of the cells and the cellular debris after rupture of the cells. However, caseinolytic activity could not be demonstrated after growth in ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550031701
更新日期：1976-05-01 00:00:00
abstract：:We evaluated the predictive and construct validity of a caries activity assessment system associated with the International Caries Detection and Assessment System (ICDAS) in primary teeth. A total of 469 children were reexamined: participants of a caries survey performed 2 yr before (follow-up rate of 73.4%). At basel...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514531017
更新日期：2014-07-01 00:00:00
abstract：:The bactericidal effect of hexylresorcinol was assessed using bacterial aggregates. Increased drug concentration resulted in decreased survival of bacteria when the aggregates were exposed to hexylresorcinol for at least eight hours. This indicates that this drug may be effective against dental plaque only when availa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580111501
更新日期：1979-11-01 00:00:00
abstract：:A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515599726
更新日期：2015-10-01 00:00:00
abstract：:Resin composites currently available are not suitable for use as large stress-bearing posterior restorations involving cusps due to their tendencies toward excessive fracture and wear. The glass fillers in composites provide only limited reinforcement because of the brittleness and low strength of glass. The aim of th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780021101
更新日期：1999-02-01 00:00:00
abstract：:Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514523783
更新日期：2014-04-01 00:00:00
abstract：:In the past two decades, accumulated evidence has clearly demonstrated the inhibitory effects of laser irradiation on enamel demineralization, but the exact mechanisms of these effects remain unclear. The purpose of this study was to investigate the effects of low-energy CO2 laser irradiation on demineralization of bo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790091401
更新日期：2000-09-01 00:00:00
abstract：:Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515602879
更新日期：2015-10-01 00:00:00
abstract：:The tissue-implant interfaces of functional and non-functional endosseous dental implants were compared histologically for up to one year post-operatively. Nonmineralized connective tissue zones (a "fibrous capsule") existed in all functional interfaces. Direct, or nearly direct, bone apposition to implants occurred i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580100201
更新日期：1979-10-01 00:00:00
abstract：:This study investigated the relevance between pulp vitality and autophagy in aged human dental pulp cells (HDPCs) and whether peroxisome proliferator-activated receptor gamma (PPARγ) affects autophagy regulation for homeostasis in the aging progress. In vivo experiments were used in human and Sprague-Dawley rat teeth ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515573833
更新日期：2015-05-01 00:00:00
abstract：:Resin-bonded bridges may replace missing teeth and act as splints in periodontal treatment. The objective of this study was to investigate the etch pattern after electrolytic etching of selected Co-Cr alloys in hydrochloric acid and to assess the changes in alloy composition after different etching times. The alloys i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660091301
更新日期：1987-09-01 00:00:00
abstract：:Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630061001
更新日期：1984-06-01 00:00:00
abstract：:Rotational freedom of the implant-abutment connection influences its screw joint stability; for optimization, influential factors need to be evaluated based on a previously developed closed formula. The underlying hypothesis is that the manufacturing tolerances, geometric pattern, and dimensions of the index do not in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509341243
更新日期：2009-08-01 00:00:00
abstract：:During the setting of a resin composite cement (RCC) used as an adhesive between a resin-bonded bridge and tooth structure, the adhesion may be disrupted by the development of shrinkage stress. The aim of this study was to investigate the influence of the shrinkage stress of three different RCCs on their adhesive and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710021101
更新日期：1992-02-01 00:00:00
abstract：:Tempering of dental porcelain by forced convective cooling in air has been shown previously to inhibit the sizes of cracks induced in porcelain surfaces. However, the depth of compressive stress that is produced by tempering of feldspathic porcelain has not been determined. It can be assumed that the potential of temp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700020701
更新日期：1991-02-01 00:00:00
abstract：:Dental porcelains that are designed to be fused to PFM (porcelain-fused-to-metal) alloys are formulated by their manufacturers to be closely matched in thermal expansion to these alloys. The high thermal expansion of the mineral leucite has been exploited to regulate porcelain expansion. Leucite, however, has been obs...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790081101
更新日期：2000-08-01 00:00:00
abstract：:The presence and kinetics of bone-resorbing activity in periapical lesions were studied with a rat model system. Lesions were found to expand most rapidly between induction on day 0 and day 15 ("active phase"), with enlargement occurring at a slower rate thereafter (days 20 and 30, "chronic phase"), as assessed by mea...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700100901
更新日期：1991-10-01 00:00:00
abstract：:Recent functional animal studies have reported that the motor control of masticatory muscle function is bilaterally guided by both hemispheres, which may fundamentally differ from the cortical control of limb muscle function. In this study, we investigated whether unilateral cortical brain infarction induces different...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780120701
更新日期：1999-12-01 00:00:00
abstract：:Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300403
更新日期：2004-04-01 00:00:00
abstract：:Solder microstructures were found to be influenced by those of the castings. A tendency of solder to match the microstructures contacted during its solidification was demonstrated. Several different types of defects were identified in the soldered joints. Tentative correlations of the observed microstructures and defe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580031401
更新日期：1979-03-01 00:00:00
abstract：:Stem cells are remarkable, and stem cell-based tissue engineering is an emerging field of biomedical science aiming to restore damaged tissue or organs. In dentistry and reconstructive facial surgery, it is of great interest to restore lost teeth or craniofacial bone defects using stem cell-mediated therapy. In the cr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515603972
更新日期：2015-11-01 00:00:00
abstract：:Selected anaerobic, capnophilic and facultative bacteria isolated from patients with various forms of periodontal health and disease were tested for their susceptibility to antibiotics and antimicrobial agents. Specific bactericidal and minimum inhibitory concentrations were compared to disc zone diameters, thereby ge...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580071401
更新日期：1979-07-01 00:00:00
abstract：:Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic de...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511421926
更新日期：2011-11-01 00:00:00
abstract：:The dimensional accuracy of porcelain fused to metal crown and bridge castings was determined on truncated cone-shaped steel dies. Ni-Cr castings produced in manufacturers' laboratories were consistently undersize, while precious metal castings were consistently oversize. Ni-Cr castings, produced in NBS laboratories u...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580120501
更新日期：1979-12-01 00:00:00
abstract：:Schoolchildren residing in a fluoride-deficient area were provided either a sodium fluoride (0.1% F) or a nonfluoride dentifrice for home use. About half the children provided each type of dentifrice were also given an initial prophylaxis. Combining the data with regard to the type of dentifrice indicated that the sod...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345750540013601
更新日期：1975-01-01 00:00:00
abstract：:The eventual outcome of dental caries is determined by the dynamic balance between pathological factors that lead to demineralization and protective factors that lead to remineralization. Pathological factors include acidogenic bacteria, inhibition of salivary function, and frequency of ingestion of fermentable carboh...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910408301s08
更新日期：2004-01-01 00:00:00
abstract：:The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF(2)) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF(2) formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808701105
更新日期：2008-11-01 00:00:00
