Abstract:
:Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to estimate the direct and indirect costs of dental diseases worldwide to approximate the global economic impact. Estimation of direct treatment costs was based on a systematic approach. For estimation of indirect costs, an approach suggested by the World Health Organization's Commission on Macroeconomics and Health was employed, which factored in 2010 values of gross domestic product per capita as provided by the International Monetary Fund and oral burden of disease estimates from the 2010 Global Burden of Disease Study. Direct treatment costs due to dental diseases worldwide were estimated at US$298 billion yearly, corresponding to an average of 4.6% of global health expenditure. Indirect costs due to dental diseases worldwide amounted to US$144 billion yearly, corresponding to economic losses within the range of the 10 most frequent global causes of death. Within the limitations of currently available data sources and methodologies, these findings suggest that the global economic impact of dental diseases amounted to US$442 billion in 2010. Improvements in population oral health may imply substantial economic benefits not only in terms of reduced treatment costs but also because of fewer productivity losses in the labor market.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Listl S,Galloway J,Mossey PA,Marcenes Wdoi
10.1177/0022034515602879subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1355-61issue
10eissn
0022-0345issn
1544-0591pii
0022034515602879journal_volume
94pub_type
杂志文章abstract::Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis (Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoacti...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508401106
更新日期:2005-11-01 00:00:00
abstract::In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680121101
更新日期:1989-12-01 00:00:00
abstract::The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available ...
journal_title:Journal of dental research
pub_type: 杂志文章,meta分析
doi:10.1177/0022034518800014
更新日期:2019-01-01 00:00:00
abstract::The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/154405910208100305
更新日期:2002-03-01 00:00:00
abstract::Understanding the mechanical properties of human teeth is important to clinical tooth preparation and to the development of "tooth-like" restorative materials. Previous studies have focused on the macroscopic fracture behavior of enamel and dentin. In the present study, we performed indentation studies to understand t...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345980770030601
更新日期:1998-03-01 00:00:00
abstract::Samples of human dental plaque were pooled from several "white spot" smooth tooth surface areas as well as from several clinically-sound tooth surface areas in each of 12 caries-positive college students. Each of the two samples from each subject was used for the determination of: (1) pH-lowering potential in vitro in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700120501
更新日期:1991-12-01 00:00:00
abstract::A conceptual means of obtaining improved bonding between filler particles and the polymeric binders of composites is presented. It involves preparing glass particles that separate into two interconnected vitreous phases when heated to an appropriate temperature, and then etching these to produce a porous surface layer...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550050701
更新日期:1976-09-01 00:00:00
abstract::Submandibular glands from young adult and aged male and female rats have been examined and various descriptive parameters obtained. Several sex differences were observed with tissue from young and old animals. Sex differences were found in the gland contents of DNA, protein, and sialic acid and in some protein compone...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600051501
更新日期:1981-05-01 00:00:00
abstract::Erupting first permanent molars of 5 1/2 to 6 1/2 year-olds are eminently suited for the clinical testing of potential caries-inhibiting techniques. Due to the rapid onset of caries in these teeth, accurate monitoring of new materials/regimes can be instituted and meaningful data obtained within one year of trial comm...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/002203457705600301011
更新日期:1977-10-01 00:00:00
abstract::Weanling rice rats were fed either standard laboratory chow or Diet 2000. The animals were sacrificed at 4, 8, 12, and 15 weeks. There was an increasing amount of exposed root surface and root surface caries with age in the animals fed Diet 2000. There was exposed root surface but no caries in the animals fed laborato...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560091701
更新日期:1977-09-01 00:00:00
abstract::Autonomic and behavioral responses to seven dental procedures were studied in 21 pedodontic patients aged six to 12. When mean pulse rate, pulse amplitude, absolute skin conductance, and skin-conductance responses were compared over all subjects, the injection of the local anesthetic consistently elicited the greatest...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620060801
更新日期:1983-06-01 00:00:00
abstract::Although the occlusal vertical dimension (OVD) is strictly controlled, the neuronal mechanism of its regulation is still unclear. We hypothesize that neurons in the trigeminal mesencephalic nucleus (MesV) play an important role in the regulation of the OVD, because the MesV receives the projection from jaw-closing mus...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200715
更新日期:2003-07-01 00:00:00
abstract::The lack of a reliable bond test has hindered the elucidation of the mechanism for porcelain-metal bonding in dental systems, because a test capable of detecting differences among porcelain-metal bonds of various qualities is required before the reasons for these differences may be ascertained. A method was developed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670020801
更新日期:1988-02-01 00:00:00
abstract::The dimensional accuracy of porcelain fused to metal crown and bridge castings was determined on truncated cone-shaped steel dies. Ni-Cr castings produced in manufacturers' laboratories were consistently undersize, while precious metal castings were consistently oversize. Ni-Cr castings, produced in NBS laboratories u...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580120501
更新日期:1979-12-01 00:00:00
abstract::The aim of the present in vitro experiments was to determine whether the protection of enamel by topically applied fluoride against demineralization by bacterial acids would depend on the fluoride sensitivity of the bacteria. Glucose-agarose gel suspensions of fluoride-sensitive and fluoride-resistant mutans streptoco...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720080401
更新日期:1993-08-01 00:00:00
abstract::Selected strains of oral Streptococcus and Actinomyces have been tested for their ability to grow in the presence of mercury. Strains were tested for growth on a semi-defined medium with low mercury-binding characteristics. Sensitivities were initially measured on agar plates, and subsequently, selected strains were g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720091201
更新日期:1993-09-01 00:00:00
abstract::Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibula...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300107
更新日期:2004-01-01 00:00:00
abstract::Enamel crystals in the demineralized zones in early caries lesions of human teeth were observed by high-resolution electron microscopy. The enamel crystals frequently exhibited perforations in their centers and defects of various sizes on their lateral surfaces. There were a number of small electron-lucent spots, sugg...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660110901
更新日期:1987-11-01 00:00:00
abstract::The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory bi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512470691
更新日期:2013-02-01 00:00:00
abstract::Mutans streptococci (MS) are generally considered to be the principal etiological agent of dental caries. MS have two important virulence factors: cell- surface protein PAc and glucosyltransferases (GTFs). GTFs have two functional domains: an N-terminal catalytic sucrose-binding domain (CAT) and a C-terminal glucan-bi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509336727
更新日期:2009-05-01 00:00:00
abstract::This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514551768
更新日期:2014-12-01 00:00:00
abstract::The effect of low-level laser treatment on maxillary arch dimensions after palatal surgery was investigated in Beagle dogs at an age of 12 weeks. A total of 30 dogs was used, and they were assigned to either a control group (Group C, n = 6) or one of two experimental groups (Group L, n = 12; and group LL, n = 12). Aft...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700111501
更新日期:1991-11-01 00:00:00
abstract::The aim of this study was to determine whether the parotid gland, like other salivary glands, produces blood group antigens. A post-embedding immunogold staining (IGS) method for ABH antigens was applied to osmicated and nonosmicated, routinely prepared specimens of normal human parotid glands. A and B antigens were n...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730021101
更新日期:1994-02-01 00:00:00
abstract::4-META and new phosphate-methacrylate resins adhere strongly to dental alloys. However, for strengthening the water durability of the adhesive interface, the oxidation of the alloy surface is indispensable. A new oxidation method using ion-sputtering was developed, and the effectiveness of this surface treatment on tw...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670110301
更新日期:1988-11-01 00:00:00
abstract::Dental enamel formation is a remarkable example of a biomineralization process. The exact mechanisms involved in this process remain partly obscure. Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta. Mutational analyses within studied families have s...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/154405910508401206
更新日期:2005-12-01 00:00:00
abstract::Nearly 100% of patients experience trauma to the trigeminal nerve during orthognathic surgery, impairing sensation and sensory function on the face. In a recent randomized clinical trial, people who performed sensory re-training exercises reported less difficulty related to residual numbness and decreased lip sensitiv...
journal_title:Journal of dental research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/154405910708600616
更新日期:2007-06-01 00:00:00
abstract::It has been shown that a release of periosteal tension may augment the growth of a long bone; however, similar experiments in the mandible have produced equivocal results. For further definition of the role of periosteal tension in the growth of the mandibular condyle, 80 young female Sprague-Dawley rats were randomly...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690090201
更新日期:1990-09-01 00:00:00
abstract::During periods of periodontal attachment loss, one of the most significant cellular changes is a decrease in the number of fibroblasts. We previously demonstrated that LPS induces apoptosis of fibroblastic cells in vivo, largely through TNF-alpha. We conducted in vivo experiments by subcutaneous inoculation of LPS in ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300903
更新日期:2004-09-01 00:00:00
abstract::Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550040401
更新日期:1976-07-01 00:00:00
abstract::In this study, we sought to determine the association between tooth agenesis and DNA sequence variation in the genes MSX1 and PAX9 in an ethnically diverse human population. Since cleft lip/palate is also associated with both tooth agenesis and the gene TGFA, we included TGFA in the analysis as well. Cheek swab sample...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300913
更新日期:2004-09-01 00:00:00