Biological assessments of experimental cavity cleansers: correlation between in vitro and in vivo studies.

abstract：:Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...

journal_title：Journal of dental research

authors： Foster BL,Sheen CR,Hatch NE,Liu J,Cory E,Narisawa S,Kiffer-Moreira T,Sah RL,Whyte MP,Somerman MJ,Millán JL

更新日期：2015-05-01 00:00:00

abstract：:In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and dif...

journal_title：Journal of dental research

authors： Yoshida S,Wada N,Hasegawa D,Miyaji H,Mitarai H,Tomokiyo A,Hamano S,Maeda H

更新日期：2016-10-01 00:00:00

abstract：:Although pulp fibroblasts are a major cell type in dental pulp, their roles in microbial recognition and pulpal inflammation are not well-understood. Considering the pivotal role of Toll-like receptors (TLRs) in the recognition of micro-organisms, we hypothesized that TLRs on pulp fibroblasts may induce inflammatory s...

journal_title：Journal of dental research

authors： Park C,Lee SY,Kim HJ,Park K,Kim JS,Lee SJ

更新日期：2010-02-01 00:00:00

abstract：:Incubation of saliva supernatant after three hours at 37 C revealed that salivary anionic proteins were susceptible to enzymatic attack by salivary enzymes not removable by centrifugation at 10,000 g. In the presence of washed suspensions of S mutans or S sanguis additional changes in electrophoretic behavior of anion...

journal_title：Journal of dental research

authors： Cowman RA,Fitzgerald RJ

更新日期：1975-03-01 00:00:00

abstract：:Tooth loss is a significant health issue currently affecting millions of people worldwide. Artificial dental implants, the current gold standard tooth replacement therapy, do not exhibit many properties of natural teeth and can be associated with complications leading to implant failure. Here we propose bioengineered ...

journal_title：Journal of dental research

authors： Smith EE,Angstadt S,Monteiro N,Zhang W,Khademhosseini A,Yelick PC

更新日期：2018-09-01 00:00:00

abstract：:Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeabilit...

journal_title：Journal of dental research

authors： Tehrani A,Goulet D,Brudevold F,Attarzadeh F

更新日期：1986-02-01 00:00:00

abstract：:The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...

journal_title：Journal of dental research

authors： Gao XJ,Elliott JC,Anderson P

更新日期：1993-05-01 00:00:00

abstract：:Focusing public insurance programs on interceptive orthodontics (IO) may increase access for low-income children. This report presents outcomes from a randomized clinical trial (RCT) comparing IO with comprehensive orthodontics (CO) in Medicaid patients. One hundred seventy pre-adolescents with Medicaid-eligible maloc...

journal_title：Journal of dental research

authors： King GJ,Spiekerman CF,Greenlee GM,Huang GJ

更新日期：2012-07-01 00:00:00

abstract：:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells ...

journal_title：Journal of dental research

authors： Yao S,Pan F,Prpic V,Wise GE

更新日期：2008-08-01 00:00:00

abstract：:We evaluated the predictive and construct validity of a caries activity assessment system associated with the International Caries Detection and Assessment System (ICDAS) in primary teeth. A total of 469 children were reexamined: participants of a caries survey performed 2 yr before (follow-up rate of 73.4%). At basel...

journal_title：Journal of dental research

authors： Guedes RS,Piovesan C,Ardenghi TM,Emmanuelli B,Braga MM,Ekstrand KR,Mendes FM

更新日期：2014-07-01 00:00:00

abstract：:The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of the human ja...

journal_title：Journal of dental research

authors： Wang K,Arendt-Nielsen L,Svensson P

更新日期：2002-09-01 00:00:00

abstract：:A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...

journal_title：Journal of dental research

authors： Wang L,Foster BL,Kram V,Nociti FH Jr,Zerfas PM,Tran AB,Young MF,Somerman MJ

更新日期：2014-08-01 00:00:00

abstract：:Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...

journal_title：Journal of dental research

authors： Nibali L,Ready DR,Parkar M,Brett PM,Wilson M,Tonetti MS,Griffiths GS

更新日期：2007-05-01 00:00:00

abstract：:The synthesis of many polycarboxylic acids is reported. An account is given of their stability in aqueous solution and the properties of cements formed by their reaction with ion-leachable glasses. A copolymer of acrylic and itaconic acids was found to combine several favorable characteristics. ...

journal_title：Journal of dental research

authors： Crisp S,Kent BE,Lewis BG,Ferner AJ,Wilson AD

更新日期：1980-06-01 00:00:00

abstract：:In this study, we investigated whether selective activation of nociceptive primary afferent fibers by capsaicin would induce modulations on tooth-pulp-evoked sensory or inhibitory masseter reflex responses in healthy human subjects. The contribution of central N-methyl-D-aspartate (NMDA) receptor mechanisms in capsaic...

journal_title：Journal of dental research

authors： Kemppainen P,Waltimo A,Waltimo T,Könönen M,Pertovaara A

更新日期：1997-09-01 00:00:00

abstract：:Juvenile rheumatoid arthritis (JRA) is a chronic systemic disease of childhood that affects synovial joints including the temporomandibular joint (TMJ). Individuals with JRA of the TMJ frequently show aberrations in mandibulofacial development. Since the basis for these developmental perturbations is poorly understood...

journal_title：Journal of dental research

authors： Tavakkoli-Jou M,Miller AJ,Kapila S

更新日期：1999-08-01 00:00:00

abstract：:In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone fo...

journal_title：Journal of dental research

authors： Liu CC,Baylink DJ

更新日期：1977-03-01 00:00:00

abstract：:The cacao bean husk has been shown to possess two types of cariostatic substances, one showing anti-glucosyltransferase (GTF) activity and the other antibacterial activity, and to inhibit experimental dental caries in rats infected with mutans streptococci. In the present study, chromatographic purification revealed h...

journal_title：Journal of dental research

authors： Osawa K,Miyazaki K,Shimura S,Okuda J,Matsumoto M,Ooshima T

更新日期：2001-11-01 00:00:00

abstract：:Not only are teeth essential for mastication, but also missing teeth are considered a social handicap due to speech and aesthetic problems, with a resulting high impact on emotional well-being. Several treatment procedures are currently available for tooth replacement with mostly inert prosthetic materials and implant...

journal_title：Journal of dental research

authors： Fleischmannova J,Matalova E,Sharpe PT,Misek I,Radlanski RJ

更新日期：2010-02-01 00:00:00

abstract：:Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...

journal_title：Journal of dental research

authors： Curzon ME

更新日期：1985-12-01 00:00:00

abstract：:This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which have been proposed in the last few years, in addition to those that are gaining some commercial exposure and clinical a...

journal_title：Journal of dental research

authors： Hall A,Girkin JM

更新日期：2004-01-01 00:00:00

abstract：:The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocente...

journal_title：Journal of dental research

authors： Huddleston Slater JJ,Vos LM,Stroy LP,Stegenga B

更新日期：2012-02-01 00:00:00

abstract：:Samples of a base mental alloy were cast and welded together using a conventional welding procedure. The joints were loaded and placed either in a corrosive environment or in air for varying time periods. The tensile and shear strength of the joints was unaffected by the corrosive environment, and the joints, despite ...

journal_title：Journal of dental research

authors： MacEntee MI,Hawbolt EB,Zahel JI

更新日期：1981-02-01 00:00:00

abstract：UNLABELLED:The aim of this observational study was to investigate the features of the chewing activity and the variability of the human chewing pace, as assessed in the natural environment. It was hypothesized that the chewing pace is relatively constant within individuals across different days but is variable across i...

journal_title：Journal of dental research

authors： Po JM,Kieser JA,Gallo LM,Tésenyi AJ,Herbison P,Farella M

更新日期：2011-10-01 00:00:00

abstract：:The effect of combined administration of chlorhexidine and fluoride in the drinking water of hamsters on plaque and caries prevention was studied. Plaque indices of the hamsters receiving chlorhexidine either alone or simultaneously with fluoride were significantly lower than those of the control and fluoride only tre...

journal_title：Journal of dental research

authors： Brayer L,Gedalia I,Gover A

更新日期：1977-11-01 00:00:00

abstract：:A study was made of the hydration of dental cements, water being classified as "non-evaporable" and "evaporable". The ratio of these two types of water was found to vary greatly among different cement types, being lesser in zinc oxide and ionic polymer cements and greater in ion-leachable glass and phosphoric acid cem...

journal_title：Journal of dental research

authors： Wilson AD,Paddon JM,Crisp S

更新日期：1979-03-01 00:00:00

abstract：:The relationship between periodontitis and systemic bone mineral density in Japanese women is undetermined. We tested the hypothesis that periodontitis was more frequent in women with low metacarpal bone mineral density (m-BMD). Subjects were 190 Japanese women (89 premenopausal, 101 post-menopausal). Periodontal stat...

journal_title：Journal of dental research

authors： Inagaki K,Kurosu Y,Kamiya T,Kondo F,Yoshinari N,Noguchi T,Krall EA,Garcia RI

更新日期：2001-09-01 00:00:00

abstract：:Stable fluoride-resistant mutants of Streptococcus mutans GS-5 were isolated on Todd-Hewitt agar by a step-wise selection procedure. Resistance is defined here as the ability to form colonies in 48 hr. First-step mutants demonstrated six different levels of resistance, ranging from 400 to 1000 micrograms/mL sodium flu...

journal_title：Journal of dental research

authors： Brussock SM,Kral TA

更新日期：1987-10-01 00:00:00

abstract：:Local anesthetic agents may be classified according to their intrinsic anesthetic potency and duration of activity. Procaine and chloroprocaine are relatively weak, short-acting drugs. Lidocaine, mepivacaine, and prilocaine represent agents of intermediate potency and duration of action. Tetracaine, bupivacaine, and e...

journal_title：Journal of dental research

authors： Covino BG,Giddon DB

更新日期：1981-08-01 00:00:00

abstract：:The feasibility of immunizing monkeys with enzymes from oral streptococci in an attempt to reduce dental caries was investigated. Forty rhesus monkeys, Macaca mulatta, were used. Cariogenic streptococci, S mutans, were implanted into all the monkeys' mouths. There was no pathological effect resulting from immunization...

journal_title：Journal of dental research

authors： Bahn AN,Shklair IL,Hayashi JA

更新日期：1977-12-01 00:00:00