Abstract：
:The feasibility of immunizing monkeys with enzymes from oral streptococci in an attempt to reduce dental caries was investigated. Forty rhesus monkeys, Macaca mulatta, were used. Cariogenic streptococci, S mutans, were implanted into all the monkeys' mouths. There was no pathological effect resulting from immunization. Of the 40 animals, 30 retained the implanted flora throughout the experiment; the remaining 10 were reimplanted until the streptococci remained. In six months, gross carious lesions were evident with plaque. Inhibitiors present in the monkey sera after immunization inhibited glucosyltransferase, fructosyltransferase, and neuraminidase activities. It was presumed the inhibitors were antibodies. There was a reduction of 68.6% in the total carious lesions in the animals immunized intraorally with glucosyltransferase, 62.4% reduction in those injected with fructosyltransferase, and 57.4% reduction in total lesions in those immunized with glycosidic hydrolases after 19 months, as compared to the control group. There were no gross lesions apparent in the group immunized with glycosidic hydrolases. It appears that immunization with enzymes significantly reduces carries and is feasible in a primate model.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Bahn AN,Shklair IL,Hayashi JAdoi
10.1177/00220345770560123001subject
Has Abstractpub_date
1977-12-01 00:00:00pages
1586-98issue
12eissn
0022-0345issn
1544-0591journal_volume
56pub_type
杂志文章abstract：:Sense of coherence (SOC) has been related to oral health behaviors and oral-health-related quality of life (OHRQoL) in observational studies. This cluster-randomized trial aimed to test the effect of an intervention to enhance SOC on OHRQoL in children. Twelve primary schools were randomly allocated to intervention an...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034512459757
更新日期：2013-01-01 00:00:00
abstract：:The goal of the present investigation was to study whether periodic use of fluoride-gel treatments resulted in an increased prevalence of dental fluorosis. 269 children, from 14 to 16 years of age, who had received semi-annual or quarterly fluoride-gel treatments were examined for possible fluoride-induced enamel chan...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640081101
更新日期：1985-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the Bruxcore Plate (BP) as a dependent measure of nocturnal bruxing activity. As part of a bruxism treatment study, we evaluated 100 nocturnal bruxers for bruxing activity before, during, and immediately after treatment and again at a six-month recall. The first 40 subjects wo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680061101
更新日期：1989-06-01 00:00:00
abstract：:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit bud-stage developmental arrest of the mandibular molar t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517713710
更新日期：2017-09-01 00:00:00
abstract：UNLABELLED:The aim of this observational study was to investigate the features of the chewing activity and the variability of the human chewing pace, as assessed in the natural environment. It was hypothesized that the chewing pace is relatively constant within individuals across different days but is variable across i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511416669
更新日期：2011-10-01 00:00:00
abstract：:Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121201
更新日期：1985-12-01 00:00:00
abstract：:The aim of this study was to test the potential of liposomes as drug carriers to the ulcerated oral mucosa. Radioactive triamcinolone acetonide palmitate (3H-TRMAp) was encapsulated in large multilamellar lipid vesicles and served as the test lotion. 3H-TRMAp in solution served as control. Forty-six hamsters were divi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650090501
更新日期：1986-09-01 00:00:00
abstract：:Blood cortisol levels of oral surgery patients were analyzed to objectively determine the effect of intravenous sedation on surgical stress. Results showed a measure of sedation but did not adequately reflect the stress of oral surgery or the changes produced by intravenous sedation. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540053501
更新日期：1975-09-01 00:00:00
abstract：:The size of a bolus determines how it will be manipulated in the mouth and swallowed. We hypothesized that mucosal sensitivity would be important for masticatory function. The accuracy of solid object size perception, spatial acuity, and food particle size reduction during mastication were measured in 22 healthy adult...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300507
更新日期：2004-05-01 00:00:00
abstract：:Eighteen different Streptococcus strains including S mutans, sanguis, mitis, salivarius, bovis, and 2F2, were assayed for their relative adsorption to synthetic hydroxyapatite and for quantities of lactic acid produced while in the adsorbed state. The results indicated that all S mutans and some S sanguis have an enha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560101401
更新日期：1977-10-01 00:00:00
abstract：:microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516657043
更新日期：2016-11-01 00:00:00
abstract：:When one uses composite resins, the curing contraction, the stiffness of the material, and the strength of the vulnerable dentinal bond are important factors in determining the marginal adaptation of the restoration. Calculations based on these intrinsic material properties have indicated that both bulk placement and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670050901
更新日期：1988-05-01 00:00:00
abstract：:Since the exposure of mutans streptococci to xylitol is known to select for xylitol-resistant (XR) natural mutants, the occurrence and long-term survival of such xylitol-resistant strains was evaluated in a cross-sectional sampling of participants of the Ylivieska xylitol study four years after the original two-year e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710110401
更新日期：1992-11-01 00:00:00
abstract：:Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200406
更新日期：2003-04-01 00:00:00
abstract：:Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509339889
更新日期：2009-07-01 00:00:00
abstract：:The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770081401
更新日期：1998-08-01 00:00:00
abstract：:In a three-year study of 145 adolescent males in a boarding school in Wisconsin, there were no statistically significant differences in dental caries experience between a group consuming phosphates added to pre-sweetened and non-presweetened ready-to-eat cereals, and the control group, or between cereal eaters and non...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345790580090201
更新日期：1979-09-01 00:00:00
abstract：:A frameshift mutation recently identified within the paired domain of the transcription factor, PAX9, has been linked to a unique form of oligodontia in a single, multigenerational family (Stockton et al., 2000). We now describe the phenotypic and segregation analyses of this remarkable kindred, the initial approach t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790070701
更新日期：2000-07-01 00:00:00
abstract：:Ammoniacal silver stain showed that there was a decrease in nucleohistones in zinc-deficient rat buccal hyperplastic epithelium as compared to control. Autoradiographic study showed that there was decreased incorporation of 3H-arginine and 3H-lysine in the hyperplastic epithelium. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560122501
更新日期：1977-12-01 00:00:00
abstract：:Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517750141
更新日期：2018-05-01 00:00:00
abstract：:Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a speci...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510382546
更新日期：2011-01-01 00:00:00
abstract：:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700801
更新日期：2008-08-01 00:00:00
abstract：:The cartilaginous nasal septa of 28 albino rats were marked with pairs of wire implants. Measurements obtained from cephalometric radiographs taken at 30 and 60 days revealed that the implants invariably separatd and did so at a rate that was highly correlated with the growth of the rest of the snout. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590081601
更新日期：1980-08-01 00:00:00
abstract：:Periodontal ligaments (PDLs) play an important role in remodeling the alveolar bond and cementum. Characterization of the periodontal tissue transcriptome remains incomplete, and an improved understanding of PDL features could aid in developing new regenerative therapies. Here, we aimed to generate and analyze a large...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516645796
更新日期：2016-08-01 00:00:00
abstract：:The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034519845001
更新日期：2019-07-01 00:00:00
abstract：:Porphyromonas gingivalis dihydroceramides are found in extracts of calculus-contaminated root surfaces, diseased gingival tissue, and atherosclerotic plaques. These ceramides have been shown to promote inflammatory secretory responses in gingival fibroblasts. Little is known about their effects on the vascular system....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600710
更新日期：2007-07-01 00:00:00
abstract：:In the absence of active pulmonary disease, mycobacterial infection frequently causes arthritis and can be considered to initiate autoimmune diseases such as rheumatoid arthritis. Temporomandibular disorder (TMD) is a disease in which pain and impaired mandibular movement appear to arise directly from degenerative or ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790100401
更新日期：2000-10-01 00:00:00
abstract：:Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reduct...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670021801
更新日期：1988-02-01 00:00:00
abstract：:Dimensions and velocity of mandibular movement are important variables in the evaluation of masticatory and speech patterns. However, little information is available concerning elderly dentates and their oral motor function and behavior. Double recordings of a chewing period, from start to swallowing, were performed i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690021101
更新日期：1990-02-01 00:00:00
abstract：:Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610091301
更新日期：1982-09-01 00:00:00
