Differentiation of stem cells in the dental follicle.

Abstract:

:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells were identified in the DF of the rat first mandibular molar by Hoechst staining, alkaline phosphatase staining, and expression of side-population stem cell markers. These cells were shown to be able to differentiate into osteoblasts/cementoblasts, adipocytes, and neurons. Treating the DF cell population with doxorubicin, followed by incubation in an adipogenesis medium, suggested that the adipocytes originated from stem cells. Thus, a possibly puripotent stem cell population is present in the rat DF.

journal_name

J Dent Res

authors

Yao S,Pan F,Prpic V,Wise GE

doi

10.1177/154405910808700801

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

767-71

issue

8

eissn

0022-0345

issn

1544-0591

pii

87/8/767

journal_volume

87

pub_type

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