Abstract：
:The Global Burden of Disease (GBD) 2010 Study produced comparable estimates of the burden of 291 diseases and injuries in 1990, 2005, and 2010. This article reports on the global burden of untreated caries, severe periodontitis, and severe tooth loss in 2010 and compares those figures with new estimates for 1990. We used disability-adjusted life-years (DALYs) and years lived with disability (YLDs) metrics to quantify burden. Oral conditions affected 3.9 billion people, and untreated caries in permanent teeth was the most prevalent condition evaluated for the entire GBD 2010 Study (global prevalence of 35% for all ages combined). Oral conditions combined accounted for 15 million DALYs globally (1.9% of all YLDs; 0.6% of all DALYs), implying an average health loss of 224 years per 100,000 population. DALYs due to oral conditions increased 20.8% between 1990 and 2010, mainly due to population growth and aging. While DALYs due to severe periodontitis and untreated caries increased, those due to severe tooth loss decreased. DALYs differed by age groups and regions, but not by genders. The findings highlight the challenge in responding to the diversity of urgent oral health needs worldwide, particularly in developing communities.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Marcenes W,Kassebaum NJ,Bernabé E,Flaxman A,Naghavi M,Lopez A,Murray CJdoi
10.1177/0022034513490168subject
Has Abstractpub_date
2013-07-01 00:00:00pages
592-7issue
7eissn
0022-0345issn
1544-0591pii
0022034513490168journal_volume
92pub_type
杂志文章abstract：:The pellicle serves as a multifunctional protective layer, providing, e.g., lubrication and remineralization and also acting as a diffusion barrier. In addition, since the formation of the pellicle precedes the adhesion of micro-organisms, it is also important as a conditioning film. We present a novel approach to stu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512456704
更新日期：2012-10-01 00:00:00
abstract：:In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and dif...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516653085
更新日期：2016-10-01 00:00:00
abstract：:One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034513490957
更新日期：2013-07-01 00:00:00
abstract：:This randomized controlled trial aimed to evaluate the duration and outcome quality of orthodontic treatment with a customized fixed appliance system versus a noncustomized system. Patients ( n = 180) were randomized and received orthodontic treatment with the Insignia customized orthodontic system or the Damon Q nonc...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034517720913
更新日期：2017-12-01 00:00:00
abstract：:Deciduous teeth were collected from children who received professional prophylaxis with an acidulated phosphate-fluoride (APF) or placebo paste and were analyzed to determine fluoride uptake. Enamel fluoride level was increased by the APF paste approximately 300 ppm at a depth of 2.5 micrometers during the first month...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550064901
更新日期：1976-11-01 00:00:00
abstract：:The relative contribution of the matrix of dentin to the physical properties of dentin is unknown but thought to be small. The objective of this study was to test the hypothesis that the demineralized matrix of dentin contributes little to the strength of dentin by measuring and comparing the ultimate tensile strength...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730061201
更新日期：1994-06-01 00:00:00
abstract：:Selected area reflection electron diffraction has been used to determine the phases present in the reaction zones surrounding the Ag-Cu eutectic dispersant in Dispersalloy amalgam. The experiments were carried out on two kinds of specimens, (1) Dispersalloy amalgam and (2) Dispersalloy amalgam using 30, 50, 75, and 10...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560090101
更新日期：1977-09-01 00:00:00
abstract：:An analysis of the relationship between creep and microstructural characteristics of several gamma2-containing amalgams showed the grain size of the Ag-Hg phase (gamma1) to be a predominant factor influencing creep. When gamma1 grain size is increased, creep is reduced. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560121401
更新日期：1977-12-01 00:00:00
abstract：:Although the occlusal vertical dimension (OVD) is strictly controlled, the neuronal mechanism of its regulation is still unclear. We hypothesize that neurons in the trigeminal mesencephalic nucleus (MesV) play an important role in the regulation of the OVD, because the MesV receives the projection from jaw-closing mus...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200715
更新日期：2003-07-01 00:00:00
abstract：:The effect of inflammation on the distribution of chondroitin sulfate and dermatan sulfate proteoglycans was assessed after normal and inflamed human gingivae were stained with monoclonal antibodies against these extracellular matrix macromolecules. The tissues were obtained following periodontal surgery and reacted w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710090801
更新日期：1992-09-01 00:00:00
abstract：:Lysis of cell wall preparations from strains representing serotypes a - g of Streptococcus mutans has provided a convenient and efficient means of obtaining the typing antigens in a soluble undegraded form, and has demonstrated that, in each case, the antigen is a cell wall component in the strict sense of a component...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620100401
更新日期：1983-10-01 00:00:00
abstract：:A single logistic curve was fitted to serial data for three cranial base lengths (S-N, Ba-N, and Ba-S) in 33 boys and 26 girls. Elongation during pubescence plus adolescence is greater in boys than girls for each length. The maximum rate of pubescent elongation occurs earliest in Ba-N. There are no consistent sex diff...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560071501
更新日期：1977-07-01 00:00:00
abstract：:The purpose of this study was to determine the surface roughness of enamel-to-enamel contact areas in order to provide a standard for comparison with surface characteristics of commercially available composite restorative materials. In addition, the inherent surface roughness of resin composites was evaluated profilom...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700091301
更新日期：1991-09-01 00:00:00
abstract：:Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduc...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034510373763
更新日期：2010-09-01 00:00:00
abstract：:The incorporation of polymerizable cationic monomers has been attempted to generate dental resinous materials with antibacterial activity. This study tested the hypothesis that a dental adhesive containing a cationic monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), would influence biofilm format...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509334499
更新日期：2009-04-01 00:00:00
abstract：:The aim of this study was to determine whether the parotid gland, like other salivary glands, produces blood group antigens. A post-embedding immunogold staining (IGS) method for ABH antigens was applied to osmicated and nonosmicated, routinely prepared specimens of normal human parotid glands. A and B antigens were n...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730021101
更新日期：1994-02-01 00:00:00
abstract：:Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510375824
更新日期：2010-10-01 00:00:00
abstract：:The extent of dental tissue destruction during the treatment of white spot lesions (WSLs) increases with the severity of the lesion. If the depth and shape of WSLs can be predicted with a noninvasive diagnostic method before dental caries treatment, more conservative interventions can be planned. Given the superiority...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518811642
更新日期：2019-03-01 00:00:00
abstract：:Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different from that of the skin, the mechanisms underlying injured pain of the oral mucosa remain poorly understood. The transient r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514565645
更新日期：2015-03-01 00:00:00
abstract：:When one uses composite resins, the curing contraction, the stiffness of the material, and the strength of the vulnerable dentinal bond are important factors in determining the marginal adaptation of the restoration. Calculations based on these intrinsic material properties have indicated that both bulk placement and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670050901
更新日期：1988-05-01 00:00:00
abstract：:The effects of demineralized dentin and bone matrix on dental ectomesenchymal cells were evaluated after observation periods of two or three weeks. Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implante...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690011301
更新日期：1990-01-01 00:00:00
abstract：:Dental diseases are now viewed as a consequence of a deleterious shift in the balance of the normally stable resident oral microbiome. It is known that frequent carbohydrate consumption or reduced saliva flow can lead to caries, and excessive plaque accumulation increases the risk of periodontal diseases. However, whe...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517742139
更新日期：2018-04-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema. Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressure, and contribute to pain and irreversible tissue damage. Lipoteichoic acid (LTA) is an amphiphilic molecule f...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200612
更新日期：2003-06-01 00:00:00
abstract：:The color of an unshaded body porcelain was determined at three thicknesses on white, gray, and three chromatic backings. Spectral absorption and scattering coefficients of the porcelain were determined from the diffuse reflectance at one thickness on the white and gray backings. These optical coefficients, when utili...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640061801
更新日期：1985-06-01 00:00:00
abstract：:PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513519801
更新日期：2014-03-01 00:00:00
abstract：:Debonding rates of 164 resin-bonded prostheses (RBP) placed from 1974 to 1985 were examined at recall. The yearly debond rates were calculated, the cumulative probability of failure was determined for the debonded RBPs, and Weibull distribution parameters were determined. For perforated prostheses, there was a high in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720081401
更新日期：1993-08-01 00:00:00
abstract：:A numerical model of the mandible, its articulating surfaces, and the forces exerted by the primary masticatory muscles has been developed for the purpose of investigating loading of the temporomandibular joint. Evidence is presented which shows that the temporomandibular joint. Evidence is presented which shows that ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650080201
更新日期：1986-08-01 00:00:00
abstract：:Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680010801
更新日期：1989-01-01 00:00:00
abstract：:Using a pin-on-disc sliding-wear test apparatus, the wear behavior of a typical composite restorative vs. styli fashioned from human enamel, sintered alumina, and magnesium fluoride was examined. The rates of restorative wear were found to be identical, within the experimental error of the measurements, for tests usin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630062501
更新日期：1984-06-01 00:00:00
abstract：:The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/00220345770560020701
更新日期：1977-02-01 00:00:00
