Mandibulofacial adaptations in a juvenile animal model of temporomandibular joint arthritis.

Abstract:

:Juvenile rheumatoid arthritis (JRA) is a chronic systemic disease of childhood that affects synovial joints including the temporomandibular joint (TMJ). Individuals with JRA of the TMJ frequently show aberrations in mandibulofacial development. Since the basis for these developmental perturbations is poorly understood, they remain a perplexing clinical problem to manage. To begin dissecting the mechanisms for altered craniofacial development in JRA of the TMJ, we characterized the gross morphologic adaptations in the facial skeleton in a juvenile animal model of TMJ arthritis. Arthritis was induced in ten 87-day-old male rabbits by intra-articular challenge with ovalbumin. Eight sham-challenged and 4 unchallenged rabbits were used as controls. Serial lateral head cephalograms, taken at 73 (T1), 87 (T2), 108 (T3), 129 (T4), and 150 (T5) days of age, were evaluated by linear measures of maxillary, mandibular, and posterior dental height dimensions. Differences in the absolute dimensions and relative percent incremental changes were compared by ANOVA and Fisher's test. The body weights, as well as the absolute measures and incremental changes in maxillary and posterior dental height dimensions, were not significantly different between the antigen-challenged and control groups. In contrast, absolute measures of posterior mandibular height, condylar neck height, and total mandibular length were significantly smaller (P < 0.05) in antigen-challenged rabbits than in both control groups at T5. Furthermore, the antigen-challenged rabbits demonstrated significantly smaller (P < 0.05) relative increases in all measures of mandibular length, and in total posterior mandibular and condylar neck heights. Cephalometric superimpositions on the cranial base and tantalum implants confirmed these quantitative observations. This investigation demonstrates mandibulofacial developmental aberrations in experimental JRA-like disease of the TMJ that are similar to those observed in humans with this disease.

journal_name

J Dent Res

authors

Tavakkoli-Jou M,Miller AJ,Kapila S

doi

10.1177/00220345990780080801

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

1426-35

issue

8

eissn

0022-0345

issn

1544-0591

journal_volume

78

pub_type

杂志文章
  • Hydrogen peroxide diffusion dynamics in dental tissues.

    abstract::The aim of this study was to investigate the diffusion dynamics of 25% hydrogen peroxide (H2O2) through enamel-dentin layers and to correlate it with dentin's structural alterations. Micro-Raman Spectroscopy (MRS) and Fourier Transform Infrared Photoacoustic Spectroscopy (FTIR-PAS) were used to measure the spectra of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513488893

    authors: Ubaldini AL,Baesso ML,Medina Neto A,Sato F,Bento AC,Pascotto RC

    更新日期:2013-07-01 00:00:00

  • Numbers of natural teeth, diet, and nutritional status in US adults.

    abstract::Evidence that dental status affects diet is equivocal. The hypothesis of this study was that diet was affected by dental status. The objective was to assess the relationship between numbers of teeth and diet and nutritional status in US adult civilians without prostheses. We examined 6985 NHANES (1988-1994) participan...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910708601206

    authors: Nowjack-Raymer RE,Sheiham A

    更新日期:2007-12-01 00:00:00

  • Hamster cheek pouch carcinoma: effect of incision and cortisone on growth, invasion, and metastasis.

    abstract::After cheek pouch carcinomas were induced in hamsters by the application of dimethylbenzanthracene (DMBA) to the right pouch for 13 weeks, the animals were divided into four groups and observed for seven more weeks. The control group received no further treatment, two experimental groups had incisional biopsies perfor...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650061401

    authors: Tsiklakis K,Wood NK,Toto PD,Doemling DB

    更新日期:1986-06-01 00:00:00

  • Capacity of buffers to inhibit acid production within dental plaque.

    abstract::An oral radiotelemetric technique was used to determine whether a range of efficient buffers had the capacity to control the levels of hydrogen ions within dental plaque in the presence of sucrose. It was found that the buffers failed to control both the intensity and duration of the acid produced. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550052601

    authors: Clarke NG,Dowdell LR

    更新日期:1976-09-01 00:00:00

  • Altered enamelin phosphorylation site causes amelogenesis imperfecta.

    abstract::Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034510365662

    authors: Chan HC,Mai L,Oikonomopoulou A,Chan HL,Richardson AS,Wang SK,Simmer JP,Hu JC

    更新日期:2010-07-01 00:00:00

  • Comparative study of the chemotactic responses of periodontal ligament cells and gingival fibroblasts to polypeptide growth factors.

    abstract::Selective recruitment of periodontal ligament cells to a previously exposed root surface is believed to enhance periodontal regeneration. It has been hypothesized that competition from gingival fibroblasts may reduce the potential of periodontal regeneration. We compared the migratory responses of PDL cells and gingiv...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345960750041401

    authors: Nishimura F,Terranova VP

    更新日期:1996-04-01 00:00:00

  • The tensile and shear strength of a base metal weld joint used in dentistry.

    abstract::Samples of a base mental alloy were cast and welded together using a conventional welding procedure. The joints were loaded and placed either in a corrosive environment or in air for varying time periods. The tensile and shear strength of the joints was unaffected by the corrosive environment, and the joints, despite ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600021101

    authors: MacEntee MI,Hawbolt EB,Zahel JI

    更新日期:1981-02-01 00:00:00

  • Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia.

    abstract::Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515573273

    authors: Foster BL,Sheen CR,Hatch NE,Liu J,Cory E,Narisawa S,Kiffer-Moreira T,Sah RL,Whyte MP,Somerman MJ,Millán JL

    更新日期:2015-05-01 00:00:00

  • Adenylate energy charge: a method for the determination of viable cell mass in dental plaque samples.

    abstract::The biochemical function, adenylate energy charge (AEC), correlates with the viable count of S. mutans. AEC may be used to estimate the percent viable fraction of bacteria in dental plaque samples. An interactive computer program designed to process the AEC data is described. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/002203457905800410011

    authors: Kemp CW

    更新日期:1979-11-01 00:00:00

  • Probiotics reduce the prevalence of oral candida in the elderly--a randomized controlled trial.

    abstract::Overgrowth of oral yeast is a common problem among the elderly. Probiotic bacteria are known to inhibit the growth of pathogenic microbes. We tested the hypothesis that cheese containing probiotic bacteria can reduce the prevalence of oral Candida. During this 16-week, randomized, double-blind, placebo-controlled stud...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/154405910708600204

    authors: Hatakka K,Ahola AJ,Yli-Knuuttila H,Richardson M,Poussa T,Meurman JH,Korpela R

    更新日期:2007-02-01 00:00:00

  • Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.

    abstract::The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0022034516639274

    authors: Tamashiro NS,Duarte PM,Miranda TS,Maciel SS,Figueiredo LC,Faveri M,Feres M

    更新日期:2016-07-01 00:00:00

  • The epidemiology of root surface caries.

    abstract::Although a secular decline is being seen in coronal caries in children in industrialized countries, there appears to be a relatively high prevalence of root caries, with chronologically older adults exhibiting the highest prevalences. This paper reviews the descriptive and analytical epidemiology of root caries as fou...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/00220345900690051901

    authors: Beck J

    更新日期:1990-05-01 00:00:00

  • Genetic Polymorphisms in FGFR2 Underlie Skeletal Malocclusion.

    abstract::Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519872951

    authors: Jiang Q,Mei L,Zou Y,Ding Q,Cannon RD,Chen H,Li H

    更新日期:2019-11-01 00:00:00

  • Orthodontic force stimulates eNOS and iNOS in rat osteocytes.

    abstract::Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tiss...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034508330861

    authors: Tan SD,Xie R,Klein-Nulend J,van Rheden RE,Bronckers AL,Kuijpers-Jagtman AM,Von den Hoff JW,Maltha JC

    更新日期:2009-03-01 00:00:00

  • Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations.

    abstract::This study's objective was to identify, in a statistically valid and efficient manner, the risk factors associated with dental implant failure. We hypothesize that factors exist which can be modified by clinicians to enhance outcome. A retrospective cohort study design was used. Cohort members had >or= one implant pla...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910208100814

    authors: Chuang SK,Wei LJ,Douglass CW,Dodson TB

    更新日期:2002-08-01 00:00:00

  • Periostomy and growth of the mandibular condyle in the rat.

    abstract::It has been shown that a release of periosteal tension may augment the growth of a long bone; however, similar experiments in the mandible have produced equivocal results. For further definition of the role of periosteal tension in the growth of the mandibular condyle, 80 young female Sprague-Dawley rats were randomly...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345900690090201

    authors: Killiany DM

    更新日期:1990-09-01 00:00:00

  • Bayesian analysis of clustered interval-censored data.

    abstract::The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diami...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/154405910508400907

    authors: Wong MC,Lam KF,Lo EC

    更新日期:2005-09-01 00:00:00

  • Cohort effects in the prevalence of caries in child populations in Tanzania.

    abstract::In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680121101

    authors: Frencken JE,Van 't Hof MA,Truin GJ,Lembariti BS,König KG

    更新日期:1989-12-01 00:00:00

  • Water aging reverses residual stresses in hydrophilic dental composites.

    abstract::Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could re...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513513905

    authors: Park JW,Ferracane JL

    更新日期:2014-02-01 00:00:00

  • The formation of hydroxyapatite-ionomer cements at 38 degrees C.

    abstract::This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345940730030501

    authors: TenHuisen KS,Brown PW

    更新日期:1994-03-01 00:00:00

  • The influence of functional use of endosseous dental implants on the tissue-implant interface. I. Histological aspects.

    abstract::The tissue-implant interfaces of functional and non-functional endosseous dental implants were compared histologically for up to one year post-operatively. Nonmineralized connective tissue zones (a "fibrous capsule") existed in all functional interfaces. Direct, or nearly direct, bone apposition to implants occurred i...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345790580100201

    authors: Brunski JB,Moccia AF Jr,Pollack SR,Korostoff E,Trachtenberg DI

    更新日期:1979-10-01 00:00:00

  • Scanning microradiographic study of the kinetics of subsurface demineralization in tooth sections under constant-composition and small constant-volume conditions.

    abstract::The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345930720051401

    authors: Gao XJ,Elliott JC,Anderson P

    更新日期:1993-05-01 00:00:00

  • Accuracy of Kubelka-Munk reflectance theory applied to human dentin and enamel.

    abstract::The Kubelka-Munk (K-M) theory provides a reflectance model for translucent materials placed on backings of different colors. We hypothesize that Kubelka-Munk (K-M) theoretical diffuse reflectance spectra of dentin and enamel are in good agreement with observed diffuse reflectance. The aim of this study was to measure ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800020901

    authors: Ragain JC Jr,Johnston WM

    更新日期:2001-02-01 00:00:00

  • Detection of periodontal disease activity with a scintillation camera.

    abstract::The goal of this study was to assess the ability of a scintillation camera method to detect areas of active bone loss due to periodontitis. Technetium 99m methylene diphosphonate was used as the bone-seeking radiopharmaceutical. Bone-seeking radiopharmaceutical uptake (BSRU) was imaged and quantified in alveolar bone ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345910700010801

    authors: Reddy MS,English R,Jeffcoat MK,Tumeh SS,Williams RC

    更新日期:1991-01-01 00:00:00

  • Low metacarpal bone density, tooth loss, and periodontal disease in Japanese women.

    abstract::The relationship between periodontitis and systemic bone mineral density in Japanese women is undetermined. We tested the hypothesis that periodontitis was more frequent in women with low metacarpal bone mineral density (m-BMD). Subjects were 190 Japanese women (89 premenopausal, 101 post-menopausal). Periodontal stat...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800090901

    authors: Inagaki K,Kurosu Y,Kamiya T,Kondo F,Yoshinari N,Noguchi T,Krall EA,Garcia RI

    更新日期:2001-09-01 00:00:00

  • Effects of Taxing Sugar-Sweetened Beverages on Caries and Treatment Costs.

    abstract::Caries increment is affected by sugar-sweetened beverage (SSB) consumption. Taxing SSBs could reduce sugar consumption and caries increment. The authors aimed to estimate the impact of a 20% SSB sales tax on caries increment and associated treatment costs (as well as the resulting tax revenue) in the context of German...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516660278

    authors: Schwendicke F,Thomson WM,Broadbent JM,Stolpe M

    更新日期:2016-11-01 00:00:00

  • Antigens and surface components associated with virulence of Actinomyces viscosus.

    abstract::We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/002203457605500111011

    authors: Hammond BF,Steel CF,Peindl KS

    更新日期:1976-01-01 00:00:00

  • A model system to demonstrate the role of cavitational activity in ultrasonic scaling.

    abstract::A model system consisting of vacuum-deposited aluminum on glass was developed to demonstrate the effectiveness of cavitational activity (occurring within the cooling water supply of a dental ultrasonic scaler) in the removal of particulate material from solid surfaces. The amount of solid material removed from the mod...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630091401

    authors: Walmsley AD,Laird WR,Williams AR

    更新日期:1984-09-01 00:00:00

  • Matrix Gla protein inhibition of tooth mineralization.

    abstract::Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700907

    authors: Kaipatur NR,Murshed M,McKee MD

    更新日期:2008-09-01 00:00:00

  • A novel missense mutation in Van der Woude syndrome: usefulness of fingernail DNA for genetic analysis.

    abstract::Van der Woude syndrome (VWS) is an autosomal-dominant oral facial disorder. To find a gene mutation in a Japanese family using fingernail DNA samples, we performed this study. We hypothesized that a gene mutation in IRF6 might be involved in VWS, and that fingernail DNA samples may be valuable for detecting such mutat...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910608501215

    authors: Matsuzawa N,Shimozato K,Natsume N,Niikawa N,Yoshiura K

    更新日期:2006-12-01 00:00:00