Abstract:
:The cacao bean husk has been shown to possess two types of cariostatic substances, one showing anti-glucosyltransferase (GTF) activity and the other antibacterial activity, and to inhibit experimental dental caries in rats infected with mutans streptococci. In the present study, chromatographic purification revealed high-molecular-weight polyphenolic compounds and unsaturated fatty acids as active components. The former, which showed strong anti-GTF activity, were polymeric epicatechins with C-4beta and C-8 intermolecular bonds estimated to be 4636 in molecular weight in an acetylated form. The latter, which showed bactericidal activity against Streptococcus mutans, were determined to be oleic and linoleic acids, and demonstrated a high level of activity at a concentration of 30 microgram/mL. The cariostatic activity of the cacao bean husk is likely caused by these biologically active constituents.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Osawa K,Miyazaki K,Shimura S,Okuda J,Matsumoto M,Ooshima Tdoi
10.1177/00220345010800111001keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
2000-4issue
11eissn
0022-0345issn
1544-0591journal_volume
80pub_type
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