Abstract:
:Nitric oxide (.NO) modulates the activity of the endocrine system in the behavioral response to stress. The purpose of this study was to investigate the effect of restraining the body of an animal on expression of neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) of the hypothalamus, and the inhibitory effect of para-masticatory activity on restraint-induced nNOS expression. We observed an increase in nNOS mRNA expression and nNOS-positive neurons in the rat hypothalamus after 30 or 60 min of restraint. Biting on a wooden stick during bodily restraint decreased nNOS mRNA expression in the hypothalamus. In addition, the number of nNOS-positive neurons was significantly reduced in the PVN of the hypothalamus. These observations clearly suggest a possible anti-stress effect of the masticatory activity of biting, and this mechanism might be unconsciously in operation during exposure to psychological stressors.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Hori N,Lee MC,Sasaguri K,Ishii H,Kamei M,Kimoto K,Toyoda M,Sato Sdoi
10.1177/154405910508400708keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
624-8issue
7eissn
0022-0345issn
1544-0591pii
84/7/624journal_volume
84pub_type
杂志文章abstract::The temporomandibular joint (TMJ) undergoes degenerative changes among patients who suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is poorly understood. We hypothesized that sustained inflammation in the TMJ induces structural abnormalities, and accordingly characterized...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512441946
更新日期:2012-05-01 00:00:00
abstract::The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...
journal_title:Journal of dental research
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doi:10.1177/0022034518822808
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abstract::Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain pre...
journal_title:Journal of dental research
pub_type: 传,历史文章,杂志文章
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更新日期:2010-07-01 00:00:00
abstract::Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their derm...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750060601
更新日期:1996-06-01 00:00:00
abstract::TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514530164
更新日期:2014-06-01 00:00:00
abstract::The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins. Much like its more famous sibling, the biological role of p63 is quite complex, with wide-ranging effects on development, differentiation, and cellular lineage choices. The crucial function of p63 is ep...
journal_title:Journal of dental research
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更新日期:2012-02-01 00:00:00
abstract::The expired air of a group of 48 persons, 40 with and eight without dental amalgam restorations, was analyzed for its mercury content before and after chewing. Expired air samples were collected in polyethylene bags, and a known quantity of each was pumped into the mercury detector for measurement. The results showed ...
journal_title:Journal of dental research
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更新日期:1981-09-01 00:00:00
abstract::The lack of a reliable bond test has hindered the elucidation of the mechanism for porcelain-metal bonding in dental systems, because a test capable of detecting differences among porcelain-metal bonds of various qualities is required before the reasons for these differences may be ascertained. A method was developed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670020801
更新日期:1988-02-01 00:00:00
abstract::Elemental analysis of two precious alloyceramic systems revealed the accumulation of Sn atoms within the interaction zone of couples subjected to a range of metal oxidation time; and varying total firing times. The source of Sn atoms which accumulated within the interaction zone was the opaque porcelain layer which co...
journal_title:Journal of dental research
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doi:10.1177/00220345770560090301
更新日期:1977-09-01 00:00:00
abstract::Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title:Journal of dental research
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doi:10.1177/00220345820610091301
更新日期:1982-09-01 00:00:00
abstract::A conceptual means of obtaining improved bonding between filler particles and the polymeric binders of composites is presented. It involves preparing glass particles that separate into two interconnected vitreous phases when heated to an appropriate temperature, and then etching these to produce a porous surface layer...
journal_title:Journal of dental research
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doi:10.1177/00220345760550050701
更新日期:1976-09-01 00:00:00
abstract::The purpose of this study was to evaluate the Bruxcore Plate (BP) as a dependent measure of nocturnal bruxing activity. As part of a bruxism treatment study, we evaluated 100 nocturnal bruxers for bruxing activity before, during, and immediately after treatment and again at a six-month recall. The first 40 subjects wo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680061101
更新日期:1989-06-01 00:00:00
abstract::Incisors of Mg-deficient rats showed a marked inhibition of eruption and a decrease in mitoses of apical tissues. Cortisone administration resulted in some increase in eruption rate and cell division though these remained below the values of Mg-supplemented controls. An improvement in gross condition and a less severe...
journal_title:Journal of dental research
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更新日期:1977-12-01 00:00:00
abstract::In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680121101
更新日期:1989-12-01 00:00:00
abstract::Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510379019
更新日期:2011-02-01 00:00:00
abstract::Stress-relaxation measurements were performed on specimens of radicular human dentin. The relaxation modulus showed a linear dependence on the logarithm of time and the approximation to the logarithmic distribution function of relaxation times was used to predict the behavior of other viscoelastic properties. This exp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540061801
更新日期:1975-11-01 00:00:00
abstract::1) A new adhesive opaque resin containing a reactive monomer, 4-methacryloxy-ethyl trimellitate anhydride (4-META), was prepared, and its application to thermosetting acrylic resin veneer crowns was studied. 2) The 4-META opaque resin was applied to a variety of nickel-chromium dental alloy specimens which had undergo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600091101
更新日期:1981-09-01 00:00:00
abstract::Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective tissue. This study investigated the hypothesis that diabetes impairs connective tissue formation in healing gingiva, and that impaired healing is associated with ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510362960
更新日期:2010-06-01 00:00:00
abstract::Minimal invasive approaches to managing caries, such as partial caries removal techniques, are showing increasing evidence of improved outcomes over the conventional complete caries removal. There is also increasing interest in techniques where no caries is removed. We present the 1-yr results of clinical efficacy for...
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pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034514550717
更新日期:2014-11-01 00:00:00
abstract::Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...
journal_title:Journal of dental research
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abstract::Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...
journal_title:Journal of dental research
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更新日期:2015-11-01 00:00:00
abstract::The human mandibular condyle has a parasagittal plate-like trabecular structure. We tested the hypothesis that this structure reflects the mechanical loading of the condyle. We developed a finite element model of the condyle to analyze the strains occurring during static compressive loading. The principal strains in t...
journal_title:Journal of dental research
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doi:10.1177/154405910208101010
更新日期:2002-10-01 00:00:00
abstract::Greater fluoride concentrations were obtained in enamel treated with phosphate/fluoride solutions than in that treated with TiF4 at similar pH's (1.0) and F concentrations (0.6M F and 1.6M F). However, fluoride solution without added phosphate at pH 1.0 and 1.6M F concentration produced lower fluoride concentrations i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580021001
更新日期:1979-02-01 00:00:00
abstract::Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in mai...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517707512
更新日期:2017-07-01 00:00:00
abstract::It has not been established whether transmission of mutans streptococci occurs between unrelated children older than 4 years of age. The aim of the study was to investigate the possible transmission of mutans streptococci genotypes from child to child in kindergarten. We studied 96 children (ages 5-6 yrs) in three San...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509353400
更新日期:2010-01-01 00:00:00
abstract::The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/00220345770560020701
更新日期:1977-02-01 00:00:00
abstract::The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded im...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200803
更新日期:2003-08-01 00:00:00
abstract::15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) and troglitazone have been shown to induce apoptosis in several carcinoma cell lines. However, apoptotic signaling pathways of these agents are poorly understood. We tested the hypothesis that peroxisome proliferator-activated receptor-gamma ligands such as these ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308201008
更新日期:2003-10-01 00:00:00
abstract::This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520952031
更新日期:2021-01-01 00:00:00
abstract::A study was made of the hydration of dental cements, water being classified as "non-evaporable" and "evaporable". The ratio of these two types of water was found to vary greatly among different cement types, being lesser in zinc oxide and ionic polymer cements and greater in ion-leachable glass and phosphoric acid cem...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580030701
更新日期:1979-03-01 00:00:00