Abstract：
:15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) and troglitazone have been shown to induce apoptosis in several carcinoma cell lines. However, apoptotic signaling pathways of these agents are poorly understood. We tested the hypothesis that peroxisome proliferator-activated receptor-gamma ligands such as these two agents will induce caspase-mediated apoptosis in human oral squamous cell carcinomas (SCC). Treatment of these cell lines with 15-d-PGJ(2) or troglitazone decreased cell viability in a time- and dose-dependent manner. 15-d-PGJ(2), but not troglitazone, induced apoptosis, and this effect was time-dependent. Exposure of cells to 20 micro M of 15-d-PGJ(2) initiated early cytochrome c release, followed by late caspase activation. Furthermore, co-treatment with caspase inhibitors such as Z-VAD-FMK or Z-DEVD-FMK of oral SCC cells that had been treated with 20 micro M of 15-d-PGJ(2) blocked apoptosis. Our study demonstrates that treatment with 15-d-PGJ(2), but not troglitazone, induces apoptosis in human SCC cell lines, and 15-d-PGJ(2) appears to work through cytochrome c release and caspase activation.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Fukuchi K,Date M,Azuma Y,Shinohara M,Takahashi H,Ohura Kdoi
10.1177/154405910308201008keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
802-6issue
10eissn
0022-0345issn
1544-0591journal_volume
82pub_type
杂志文章abstract：:Light propagation in human dentin exhibits a strong directional dependence featuring the long-known optical magnification property. We hypothesized that this anisotropic effect is caused by multiple scattering at the dentin tubules, and not by fiberoptic effects, as had been previously assumed. We performed measuremen...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501017
更新日期：2006-10-01 00:00:00
abstract：:A sintered hydroxyapatite (HAP) ceramic for use in wear studies was prepared from a commercial tricalcium phosphate. The sintered HAP had physical properties close to those of human enamel. The coefficient of friction and wear of the sintered HAP ceramic as characterized by tangential force, track width, and surface f...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570070401
更新日期：1978-07-01 00:00:00
abstract：:Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic ba...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515606045
更新日期：2015-12-01 00:00:00
abstract：:Investigations of the maturation pattern of rat incisor enamel by quantitative electron microscopy and electron-probe microanalysis indicate that mineralization of rat enamel can be regarded, as in humans, as a regular and progressive process pattern of enamel matrix formation. The species variations that have been pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580024201
更新日期：1979-03-01 00:00:00
abstract：:This study investigated the association between caries status and sealant need at a prior survey and subsequent sealant use in a Medicaid program. Clinical data from a 1986-87 statewide epidemiological survey (N = 8026) representative of North Carolina (NC) schoolchildren (grades K-12) were linked with all NC Medicaid...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760120901
更新日期：1997-12-01 00:00:00
abstract：:The purpose of this study was to evaluate the Bruxcore Plate (BP) as a dependent measure of nocturnal bruxing activity. As part of a bruxism treatment study, we evaluated 100 nocturnal bruxers for bruxing activity before, during, and immediately after treatment and again at a six-month recall. The first 40 subjects wo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680061101
更新日期：1989-06-01 00:00:00
abstract：:Periodontitis is a chronic inflammatory disease affecting oral tissues. The continuous, high production of cytokines by host cells triggered by periodontopathogens is thought to be responsible for the destruction of tooth-supporting tissues. Macrophages play a critical role in this host inflammatory response to period...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500306
更新日期：2006-03-01 00:00:00
abstract：:Dimensions and velocity of mandibular movement are important variables in the evaluation of masticatory and speech patterns. However, little information is available concerning elderly dentates and their oral motor function and behavior. Double recordings of a chewing period, from start to swallowing, were performed i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690021101
更新日期：1990-02-01 00:00:00
abstract：:Multiple interactions occur among major determinants of dental caries. We have studied the bacterial flora and pH-lowering capacity of the same dental plaques in relation to caries. The findings on the plaque flora are reported here. The buccal surfaces of upper teeth in each subject were selected for study. A low-car...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790021201
更新日期：2000-02-01 00:00:00
abstract：:Schoolchildren residing in a fluoride-deficient area were provided either a sodium fluoride (0.1% F) or a nonfluoride dentifrice for home use. About half the children provided each type of dentifrice were also given an initial prophylaxis. Combining the data with regard to the type of dentifrice indicated that the sod...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345750540013601
更新日期：1975-01-01 00:00:00
abstract：:Samples of human dental plaque were pooled from several "white spot" smooth tooth surface areas as well as from several clinically-sound tooth surface areas in each of 12 caries-positive college students. Each of the two samples from each subject was used for the determination of: (1) pH-lowering potential in vitro in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700120501
更新日期：1991-12-01 00:00:00
abstract：:Knoop hardness measurements of UV-polymerized dental composites showed that, at a certain depth below the surface, the degree of cure rapidly decreases. The depth of cure was found to be critically dependent on the UV source and exposure time used. A theoretical model was derived which was in quantitative accord with ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590050901
更新日期：1980-05-01 00:00:00
abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520913873
更新日期：2020-07-01 00:00:00
abstract：:The aim of this study was to test the hypothesis that the chewing of xylitol- or xylitol/sorbitol-containing chewing gum reduces plaque formation and the acidogenic potential of dental plaque. Thirty healthy volunteers aged from 19 to 28 yrs were randomly allocated to one of three test groups, chewing either xylitol-,...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345980770071001
更新日期：1998-07-01 00:00:00
abstract：:After cheek pouch carcinomas were induced in hamsters by the application of dimethylbenzanthracene (DMBA) to the right pouch for 13 weeks, the animals were divided into four groups and observed for seven more weeks. The control group received no further treatment, two experimental groups had incisional biopsies perfor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650061401
更新日期：1986-06-01 00:00:00
abstract：:In the rat parotid acinar cell, methacholine caused an increase in [Ca2+]i as determined by quin-2 fluorescence. The increase in [Ca2+]i was initially independent of, and subsequently dependent on, the presence of extracellular Ca2+, indicating mobilization of intracellular Ca2+, as well as activation of Ca2+ entry. M...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660022701
更新日期：1987-02-01 00:00:00
abstract：:Dental implants have become an increasingly popular treatment choice for replacing missing teeth. Yet, little is known about the prevalence and sociodemographic distribution of dental implant use in the United States. To address this knowledge gap, we analyzed data from 7 National Health and Nutrition Examination Surv...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/0022034518792567
更新日期：2018-12-01 00:00:00
abstract：:Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910308200311
更新日期：2003-03-01 00:00:00
abstract：:Mucous membrane pemphigoid or cicatricial pemphigoid is a mucocutaneous blistering disease characterized by autoantibodies to different molecules in the basement membrane zone. Our objectives were to identify the target antigen recognized by sera from 20 untreated patients with pemphigoid disease limited to the oral c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800080601
更新日期：2001-08-01 00:00:00
abstract：:This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550050601
更新日期：1976-09-01 00:00:00
abstract：:Tumor progression is often associated with altered glycosylation of the cell-surface proteins and lipids. The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens. The expression of histo-blood-group antigens in normal human tissu...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910508400103
更新日期：2005-01-01 00:00:00
abstract：:The objective of this study was to assess the relative effects of age and oral hygiene on the progression of periodontitis by estimating incidence from age-specific prevalence. This study analyzed data from a representative national sample of 14,690 dentate Americans, aged from 15 to 74, seen in the first National Hea...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660010201
更新日期：1987-01-01 00:00:00
abstract：:This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730030501
更新日期：1994-03-01 00:00:00
abstract：:Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570110901
更新日期：1978-11-01 00:00:00
abstract：:Although dental amalgam is used frequently under artificial crowns for restoration of severely damaged teeth, there is little information available on the bond between luting cements and this alloy. This study was designed for determination of the strength of the bond between a dental amalgam alloy and three crown-lut...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680111501
更新日期：1989-11-01 00:00:00
abstract：:Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and "4b", the latter being as yet unidentified in AMELX transcripts. To learn more about the evolutionary origin of these exons, we used an in silico approach to find th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511423399
更新日期：2012-01-01 00:00:00
abstract：:The importance of assessing the impact of treatments for chronic conditions on an individual's quality of life has been well-established. In this randomized clinical trial, oral-health-related quality of life, measured with the Oral Health Impact Profile (OHIP), was compared between two groups of edentulous patients. ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345000790090401
更新日期：2000-09-01 00:00:00
abstract：:Periodontitis is a complex, multifactorial chronic disease involving continuous interactions among bacteria, host immune/inflammatory responses, and modifying genetic and environmental factors. More than any other cytokine family, the interleukin (IL)-1 family includes key signaling molecules that trigger and perpetua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520945209
更新日期：2020-12-01 00:00:00
abstract：:The most frequent complaints registered against composite restorations are stained margins and a rough surface. The stained margins have many causes such as (1) fracturing or crazing of enamel during preparation of the cavity, (2) using a composite having an excessive curing shrinkage, (3) manipulating too slowly, whi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580052101
更新日期：1979-05-01 00:00:00
abstract：:Information on the time-dependent release of fluoride from filled resins containing fluoride particles as a function of particle content and solution pH is limited. This study characterized the fluoride ion release from filled resins containing CaF2 particles as a function of filler content and pH. Urethane dimethacry...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400508
更新日期：2005-05-01 00:00:00
