Abstract：
:Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and "4b", the latter being as yet unidentified in AMELX transcripts. To learn more about the evolutionary origin of these exons, we used an in silico approach to find them in 39 tetrapod genomes. AMEL organization with 6 exons was the ancestral condition. Exon 4 was created in an ancestral therian (marsupials + placentals), then exon 9 in an ancestral placental, and finally exons "4b" and 8 in rodents, after divergence of the squirrel lineage. These exons were either inactivated in some lineages or remained functional: Exon 4 is functional from artiodactyls onward; exon 9 is known, to date, only in rodents, but could be coding in various mammals; and exon "4b" was probably coding in some rodents. We performed PCR of cDNA isolated from mouse and human tooth buds to identify the presence of these transcripts. A sequence analogous to exon "4b", and to exon 9, could not be amplified from the respective tooth cDNA, indicating that even though sequences similar to these exons are present, they are not transcribed in these species.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Sire JY,Huang Y,Li W,Delgado S,Goldberg M,Denbesten PKdoi
10.1177/0022034511423399subject
Has Abstractpub_date
2012-01-01 00:00:00pages
84-9issue
1eissn
0022-0345issn
1544-0591pii
0022034511423399journal_volume
91pub_type
杂志文章abstract：:Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tiss...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034508330861
更新日期：2009-03-01 00:00:00
abstract：:Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined the effect of including 2 MMP inhibito...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512446339
更新日期：2012-06-01 00:00:00
abstract：:A study was made of the hydration of dental cements, water being classified as "non-evaporable" and "evaporable". The ratio of these two types of water was found to vary greatly among different cement types, being lesser in zinc oxide and ionic polymer cements and greater in ion-leachable glass and phosphoric acid cem...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580030701
更新日期：1979-03-01 00:00:00
abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage pain and inflammatory disorders. We hypothesized that gingival fibroblasts actively accumulate NSAIDs and enhance their levels in gingival connective tissue. Using fluorescence to monitor NSAID transport, we demonstrated that cultured gingival fibroblas...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500511
更新日期：2006-05-01 00:00:00
abstract：:Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590071001
更新日期：1980-07-01 00:00:00
abstract：:A detailed understanding of the complexity of root canal systems is imperative to ensure successful root canal preparation. The aim of this study was to evaluate the potential and accuracy of a three-dimensional, non-destructive technique for detailing root canal geometry by means of high-resolution tomography. The an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790060901
更新日期：2000-06-01 00:00:00
abstract：:These studies defined the normal and hormonally altered development of activity for tyrosine hydroxylase (T-OH), the rate-limiting enzyme in catecholamine biosynthesis (Levitt et al., 1965), and choline acetyltransferase activity (CAT) in the male rat superior cervical ganglion (SCG). Additionally, salivary gland weig...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660030901
更新日期：1987-03-01 00:00:00
abstract：:The tongue plays an important role in mastication and swallowing by its contact with the hard palate. Using an experimental palatal plate with 7 pressure sensors, and recording jaw movement using mandibular kinesiography, we assessed, in healthy subjects, the coordination of tongue and jaw movements during the entire ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500214
更新日期：2006-02-01 00:00:00
abstract：:In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517720403
更新日期：2017-10-01 00:00:00
abstract：:Two series of dental composites, along with the unfilled resin matrix, were examined to determine the effects of filler level and size on selected properties. Both series were prepared by incorporating a silanated barium borosilicate filler into a visible-light-activated polyphenylene polymethacrylate resin matrix. On...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121501
更新日期：1985-12-01 00:00:00
abstract：:Medication-related osteonecrosis of the jaw (MRONJ), although initially believed to be exclusively associated with bisphosphonates, has been implicated in recent reports with additional drugs, especially the bone antiresorptive denosumab. The pathophysiology has not been fully elucidated, and no causal association bet...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515572021
更新日期：2015-04-01 00:00:00
abstract：:The amount of free water in 50 samples of air-dried enamel from permanent and deciduous teeth was measured by the Karl Fischer method. Samples included both contemporary and burial specimens. The mean values obtained showed that free water constituted about 1% of enamel mass. However, the range of individual values va...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/00220345880670051701
更新日期：1988-05-01 00:00:00
abstract：:The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501205
更新日期：2006-12-01 00:00:00
abstract：:Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515572190
更新日期：2015-04-01 00:00:00
abstract：:ATP-degrading enzyme activities in pulps of healthy and carious human teeth were quantitatively analyzed using the bioluminescence method. The patterns of both Ca2+- and MG2+-activated ATP hydrolysis resembled each other. Increased enzyme activities were observed during injured states. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600020601
更新日期：1981-02-01 00:00:00
abstract：:Elemental analysis of two precious alloyceramic systems revealed the accumulation of Sn atoms within the interaction zone of couples subjected to a range of metal oxidation time; and varying total firing times. The source of Sn atoms which accumulated within the interaction zone was the opaque porcelain layer which co...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560090301
更新日期：1977-09-01 00:00:00
abstract：:Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515573273
更新日期：2015-05-01 00:00:00
abstract：:Relative glycogen synthetic abilities of resting cells of fresh clinical isolates of Actinomyces viscosus and Actinomyces naeslundii originating from dental plaque samples over root surface caries lesions and non-carious sites were studied under anaerobic conditions at a constant pH of 7.0, with U-(14C)-glucose used a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650060701
更新日期：1986-06-01 00:00:00
abstract：:The goal of this study was to assess the ability of a scintillation camera method to detect areas of active bone loss due to periodontitis. Technetium 99m methylene diphosphonate was used as the bone-seeking radiopharmaceutical. Bone-seeking radiopharmaceutical uptake (BSRU) was imaged and quantified in alveolar bone ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700010801
更新日期：1991-01-01 00:00:00
abstract：:The DMF index provides one source of information on past and present dental caries experience; however, important limitations hinder its ability to characterize fully the impact of dental caries. The purpose of this paper is to describe a measure of selected restoration and tooth conditions that supplements informatio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203459607502S06
更新日期：1996-02-01 00:00:00
abstract：:A sintered hydroxyapatite (HAP) ceramic for use in wear studies was prepared from a commercial tricalcium phosphate. The sintered HAP had physical properties close to those of human enamel. The coefficient of friction and wear of the sintered HAP ceramic as characterized by tangential force, track width, and surface f...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570070401
更新日期：1978-07-01 00:00:00
abstract：UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512463241
更新日期：2013-01-01 00:00:00
abstract：:Lysozyme concentration was quantitated immunochemically in parotid and submandibular-sublingual saliva of 46 caries-resistant and 17 caries-susceptible adults. There was essentially no difference between the two groups. The concentration of lysozyme was three times higher in the submandibular-sublingual than in the pa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620050701
更新日期：1983-05-01 00:00:00
abstract：:The differential diagnosis of dental wear lesions affects their clinical management. We hypothesized that surface texture parameters can differentiate simulated erosion, abrasion, and erosion-abrasion lesions on human enamel and dentin. This in vitro study comprised 2 parts (both factorial 4 × 2), with 4 lesion types ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516629941
更新日期：2016-05-01 00:00:00
abstract：:With clinical oral examinations not always possible in health surveys, researchers may instead be invited to add questions to a wider health survey. In such situations, an item is needed which adequately represents both clinical and self-reported oral health. This study investigated the clinical validity of Locker's g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512460676
更新日期：2012-11-01 00:00:00
abstract：:Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510397614
更新日期：2011-06-01 00:00:00
abstract：:Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a speci...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510382546
更新日期：2011-01-01 00:00:00
abstract：:An in vitro model has been developed for measurement of initial attachment of 3H-labeled human gingival fibroblasts (HGF) and periodontal ligament cells (HPDL cells) to sieved dentin powder. Reproducible attachment was obtained and was closely related to the number of plated cells, the amount of dentin powder, the tem...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720030901
更新日期：1993-03-01 00:00:00
abstract：:Enamel crystals in the demineralized zones in early caries lesions of human teeth were observed by high-resolution electron microscopy. The enamel crystals frequently exhibited perforations in their centers and defects of various sizes on their lateral surfaces. There were a number of small electron-lucent spots, sugg...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660110901
更新日期：1987-11-01 00:00:00
abstract：:The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708601111
更新日期：2007-11-01 00:00:00
