Abstract：
:Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined the effect of including 2 MMP inhibitors (BB94 and GM6001) within the primers of 3 commercially available adhesives. Fluorometric assay and zymography showed that adhesives with MMP inhibitors had high affinity toward both synthetic fluorogenic FRET peptides (95%) and dentin powder substrates, respectively. The immediate microtensile bond strength was enhanced for 2 types of adhesives following the addition of both inhibitors. However, no changes were detected between the control and the inhibitor groups following 3-month storage. The modified two-step etch-and-rinse and single-step systems showed less Rhodamine B penetration to the "hybrid layer" and to the "adhesive", respectively. The incorporation of BB94 and GM6001 within the primers resulted in the inhibition of dentin MMPs with improved initial bond strength and enhanced sealing ability.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Almahdy A,Koller G,Sauro S,Bartsch JW,Sherriff M,Watson TF,Banerjee Adoi
10.1177/0022034512446339subject
Has Abstractpub_date
2012-06-01 00:00:00pages
605-11issue
6eissn
0022-0345issn
1544-0591pii
0022034512446339journal_volume
91pub_type
杂志文章abstract：:Cross-sectional areas of the masseter, temporalis and medial, and lateral pterygoid muscles were determined in 16 subjects by means of computer tomography. In each subject three scans were made, intersecting the thickest part of the muscles at right angles to the fiber direction. The masseter and medial pterygoid musc...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630091201
更新日期：1984-09-01 00:00:00
abstract：:Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for hybrid layer degradation. Since chlorhexidine inhibits MMPs, we hypothesized that chlorhexidine would decelerate the loss of resin-dentin bonds. Class I preparations in extracted th...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600115
更新日期：2007-01-01 00:00:00
abstract：:The etiology and pathogenesis of craniofacial birth defects are multifactorial and include both genetic and environmental factors. Despite the identification of numerous genes associated with congenital craniofacial anomalies, our understanding of their etiology remains incomplete, and many affected individuals have a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520969109
更新日期：2020-11-06 00:00:00
abstract：:An indirect extrusion capillary viscometer has been developed. This has been tested for nonsetting Newtonian fluids and was found to give results close to, but slightly lower than the actual viscosity. The same apparatus has been successfully applied to a non-Newtonian fluid to determine the dependence of viscosity on...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550021001
更新日期：1976-03-01 00:00:00
abstract：:Caregivers' health literacy has emerged as an important determinant of young children's health care and outcomes. We examined the hypothesis that caregivers' health literacy influences children's oral-health-care-related expenditures. This was a prospective cohort study of 1,132 child/caregiver dyads (children's mean ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513484335
更新日期：2013-07-01 00:00:00
abstract：:The proton probe has been used to map F concentration changes in the enamel of 15 teeth showing clinical evidence of caries. Thin sections through the lesions were microradiographed and measurements made of the surface zone (radiodense) and body (radiolucent) areas. Each section was then scanned with a focused beam of...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740111001
更新日期：1995-11-01 00:00:00
abstract：:Previous studies have shown that fluoride affected the formation of apatite in spontaneous precipitations from unstable calcium phosphate solutions partly through its effect on the stability of such nonapatitic precursors as octacalcium phosphate, Ca8H2(PO4)6.5 H2O. The present study shows that fluoride had a comparab...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590021401
更新日期：1980-02-01 00:00:00
abstract：:Wall-to-wall (WTW) polymerization contraction of filled and unfilled chemically and photo-initiated resins was studied in relation to the WTW distance. In an experimental set-up, the resins were bonded to two opposing disks, and the axial (WTW) displacement resulting from the polymerization shrinkage was measured cont...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680010701
更新日期：1989-01-01 00:00:00
abstract：:The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available ...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析
doi：10.1177/0022034518800014
更新日期：2019-01-01 00:00:00
abstract：:This study demonstrated that human submandibular-sublingual saliva (HSMSL) provided a better substrate than did whole saliva or parotid saliva for the binding of Streptococcus sanguis in a glass adherence assay. Additional evidence indicated that the lower molecular weight salivary mucin in HSMSL was involved in these...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610120101
更新日期：1982-12-01 00:00:00
abstract：:Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510376543
更新日期：2010-11-01 00:00:00
abstract：:Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective tissue. This study investigated the hypothesis that diabetes impairs connective tissue formation in healing gingiva, and that impaired healing is associated with ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510362960
更新日期：2010-06-01 00:00:00
abstract：:In mineralizing hamster molars, the influence of several inhibitors on p-NPP-ase has been demonstrated, and compared with their effect on PPi-ase, known to belong to the same enzyme. Whereas the latter activity is much more physiological, p-NPP is a better substrate to distinguish between the effects of bivalent catio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560102701
更新日期：1977-10-01 00:00:00
abstract：:Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780070701
更新日期：1999-07-01 00:00:00
abstract：:Hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) are the volatile sulfur compounds (VSC) that were investigated for a possible role in the etiology of periodontal disease. The results show that the permeability of porcine non-keratinized sublingual mucosa is increased by up to 75% or 103% following exposure to H2S ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630071701
更新日期：1984-07-01 00:00:00
abstract：:The work described considers the effects on calcified tissues of those concentrations of fluoride which are not overtly cyto-toxic, i.e., in the general region of up to 1-2 mumol/L. Plasma fluoride concentrations or those of the cellular environment are considered rather than dietary levels. The effect of fluoride ion...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690S134
更新日期：1990-02-01 00:00:00
abstract：:The eventual outcome of dental caries is determined by the dynamic balance between pathological factors that lead to demineralization and protective factors that lead to remineralization. Pathological factors include acidogenic bacteria, inhibition of salivary function, and frequency of ingestion of fermentable carboh...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910408301s08
更新日期：2004-01-01 00:00:00
abstract：:This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060601
更新日期：1988-06-01 00:00:00
abstract：:The aim of this study was to examine the association between the bone mass (bone mineral content [BMC]) and hypomineralized second primary molars (HSPMs)/molar incisor hypomineralization (MIH) in 6-y-old children. This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625470
更新日期：2016-04-01 00:00:00
abstract：:The cacao bean husk has been shown to possess two types of cariostatic substances, one showing anti-glucosyltransferase (GTF) activity and the other antibacterial activity, and to inhibit experimental dental caries in rats infected with mutans streptococci. In the present study, chromatographic purification revealed h...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800111001
更新日期：2001-11-01 00:00:00
abstract：:Tooth agenesis is one of the most common developmental anomalies affecting function and esthetics. The paired-domain transcription factor, Pax9, is critical for patterning and morphogenesis of tooth and taste buds. Mutations of PAX9 have been identified in patients with tooth agenesis. Despite significant progress in ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517729322
更新日期：2018-02-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:The effects of demineralized dentin and bone matrix on dental ectomesenchymal cells were evaluated after observation periods of two or three weeks. Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implante...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690011301
更新日期：1990-01-01 00:00:00
abstract：:Minimally invasive caries-removal procedures remove only caries-infected dentin and preserve caries-affected dentin that becomes remineralized. Dental cements containing calcium phosphate promote remineralization. This study evaluated the in vivo remineralization capacity of resin-based calcium-phosphate cement (Ca-P)...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034509360155
更新日期：2010-03-01 00:00:00
abstract：:Sense of coherence (SOC) has been related to oral health behaviors and oral-health-related quality of life (OHRQoL) in observational studies. This cluster-randomized trial aimed to test the effect of an intervention to enhance SOC on OHRQoL in children. Twelve primary schools were randomly allocated to intervention an...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034512459757
更新日期：2013-01-01 00:00:00
abstract：:Urinary catecholamines have been used to measure emotionally stressful states which may affect the development of dental caries. This study investigates the hypothesis that children with and without dental caries do not differ significantly in the mean values of urinary catecholamines such as epinephrine, norepinephri...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740100801
更新日期：1995-10-01 00:00:00
abstract：:Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510375824
更新日期：2010-10-01 00:00:00
abstract：:Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck ca...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510388037
更新日期：2011-03-01 00:00:00
abstract：:Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750090901
更新日期：1996-09-01 00:00:00
