Abstract:
:Hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) are the volatile sulfur compounds (VSC) that were investigated for a possible role in the etiology of periodontal disease. The results show that the permeability of porcine non-keratinized sublingual mucosa is increased by up to 75% or 103% following exposure to H2S and CH3SH, respectively. The effect may be attributed to VSC reaction with tissue components resulting in alteration in the integrity of the tissue barrier. The increase in permeability of the mucosa to [35S]-Na2SO4 was dependent on both the time of exposure and concentration of VSC in the head-space. The [35S]-H2S was retained by the mucosal tissue and was able to penetrate the intact layers consisting of non-keratinized epithelium, basal membrane, and connective tissue. Treatment of the mucosa with 0.22% ZnCl2, either prior to or after exposure to CH3SH, nullified the effect of CH3SH and restored the permeability to a state similar to that observed in control 95% air/5% CO2 systems.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Ng W,Tonzetich Jdoi
10.1177/00220345840630071701subject
Has Abstractpub_date
1984-07-01 00:00:00pages
994-7issue
7eissn
0022-0345issn
1544-0591journal_volume
63pub_type
杂志文章abstract::This study was undertaken in order to correlate the immune status of persons with various types of immune dysfunctions with the incidence of dental caries. Preliminary data on caries experience and the microbial composition of plaque in these individuals are presented. The findings suggest that persons with immunoglob...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560030201
更新日期:1977-03-01 00:00:00
abstract::This study has identified and characterized class II (Ia) antigen-expressing cells in the normal rat incisor pulp by immunohistochemistry and flow cytometry. Two types of Ia-expressing cells occurred: one with a pronounced dendritic appearance located primarily in the periphery of the pulp, and one with morphological ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670100301
更新日期:1988-10-01 00:00:00
abstract::Physico-chemical investigations of enamel from deciduous teeth of a small number of children with and without pre-natal fluoride supplementation (PNF) exhibited the following differences between the PNF and non-PNF enamel, with the former showing: (a) more homogeneous and less extensive patterns of acid-etching; (b) d...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640031601
更新日期:1985-03-01 00:00:00
abstract::The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of the human ja...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208100915
更新日期:2002-09-01 00:00:00
abstract::Patients with restorations cemented with a reinforced zinc oxide-eugenol cement and a zinc phosphate cement were recalled after a four- to seven-year interval. No significant differences in clinical success were observed between restoration luted with the two cements. No significant difference in the incidence of cari...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022201
更新日期:1976-03-01 00:00:00
abstract::Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without com...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512472335
更新日期:2013-03-01 00:00:00
abstract::Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600021501
更新日期:1981-02-01 00:00:00
abstract::The aim of this study was to investigate the diffusion dynamics of 25% hydrogen peroxide (H2O2) through enamel-dentin layers and to correlate it with dentin's structural alterations. Micro-Raman Spectroscopy (MRS) and Fourier Transform Infrared Photoacoustic Spectroscopy (FTIR-PAS) were used to measure the spectra of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513488893
更新日期:2013-07-01 00:00:00
abstract::Although pulp fibroblasts are a major cell type in dental pulp, their roles in microbial recognition and pulpal inflammation are not well-understood. Considering the pivotal role of Toll-like receptors (TLRs) in the recognition of micro-organisms, we hypothesized that TLRs on pulp fibroblasts may induce inflammatory s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509354720
更新日期:2010-02-01 00:00:00
abstract::The fluid in and gingival tissue lining periodontal pockets were collected from male patients undergoing periodontal therapy. The collagenolytic activity of the crevicular fluid, and the ability of the gingiva in culture to degrade (a) an exogenous collagen substrate, and (b) endogenous collagen newly synthesized and ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580111601
更新日期:1979-11-01 00:00:00
abstract::The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345980770081401
更新日期:1998-08-01 00:00:00
abstract::Adenosine has various biological effects on human gingival fibroblasts (HGF) and epithelial cells closely associated with inflammation, such as cytokine production and cell adhesion. However, the mechanism of adenosine formation in periodontal tissues is not yet defined. In this study, we examined the involvement of C...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308201108
更新日期:2003-11-01 00:00:00
abstract::Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for hybrid layer degradation. Since chlorhexidine inhibits MMPs, we hypothesized that chlorhexidine would decelerate the loss of resin-dentin bonds. Class I preparations in extracted th...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/154405910708600115
更新日期:2007-01-01 00:00:00
abstract::The relative contribution of the matrix of dentin to the physical properties of dentin is unknown but thought to be small. The objective of this study was to test the hypothesis that the demineralized matrix of dentin contributes little to the strength of dentin by measuring and comparing the ultimate tensile strength...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730061201
更新日期:1994-06-01 00:00:00
abstract::Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within s...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/0022034519837252
更新日期:2019-06-01 00:00:00
abstract::Insulin resistance is one of the critical pathogeneses of type 2 diabetes mellitus (T2DM). Elevated levels of plasma branched-chain amino acids (BCAAs) are associated with insulin resistance. Recent studies have demonstrated the role of Porphyromonas gingivalis in the development of insulin resistance. However, the me...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520911037
更新日期:2020-07-01 00:00:00
abstract::Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610091301
更新日期:1982-09-01 00:00:00
abstract:UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512463241
更新日期:2013-01-01 00:00:00
abstract::Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to e...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515602879
更新日期:2015-10-01 00:00:00
abstract::Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) are expressed as a single mRNA transcript coding for a large precursor protein termed dentin sialophosphoprotein (DSPP). DSP, DPP, and DSPP have been considered to be tooth-specific. To test for the expression of the dspp gene in bone, we performed Western immu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208100607
更新日期:2002-06-01 00:00:00
abstract::The purpose of this study was to investigate the mechanism of surface layer formation in artificial white spots. Two nondestructive nuclear micro-analysis techniques were employed to analyze windows of human dental enamel at progressive stages of an artificial lesion. Fluoride concentrations were measured to a depth o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620091001
更新日期:1983-09-01 00:00:00
abstract:UNLABELLED:The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034510393516
更新日期:2011-05-01 00:00:00
abstract::Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808701210
更新日期:2008-12-01 00:00:00
abstract::Over the last hundred years, groundbreaking research in oral microbiology has provided a broad and deep understanding about the oral microbiome, its interactions with our body, and how the community can affect our health, be protective, or lead to the development of dental diseases. During this exciting journey, hypot...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034519830686
更新日期:2019-04-01 00:00:00
abstract::Stereologic studies of trabecular architecture suggest that the pig mandibular condyle is strongest when loaded supero-inferiorly, and that stress is concentrated in the antero-inferior region (Teng and Herring, 1995). To test these hypotheses, we investigated the uni-axial mechanical properties of 22 pig mandibular c...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750110501
更新日期:1996-11-01 00:00:00
abstract::Indigenous populations around the world experience a disproportionate burden in terms of oral diseases and conditions. These inequalities are likely due to a complex web of social determinants that includes poverty, historical consequences of colonialism, social exclusion, government policies of assimilation, cultural...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034518763605
更新日期:2018-07-01 00:00:00
abstract::Diabetes mellitus is associated with depression of natural defenses against infection and increases the risk of periodontal disease. However, the effects of diabetes on periradicular tissue, which differs structurally from periodontal tissue, are not known. In this study, we evaluated the effects of type 2 diabetes on...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200416
更新日期:2003-04-01 00:00:00
abstract::Current challenges in adhesive dentistry include over-hydrophilic bonding formulations, which facilitate water percolation through the hybrid layer and result in unreliable bonded interfaces. This study introduces nanogel-modified adhesives as a way to control the material's hydrophobic character without changing the ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034511426573
更新日期:2012-02-01 00:00:00
abstract::Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in mai...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517707512
更新日期:2017-07-01 00:00:00
abstract::Interfacial bond strengths of light-activated composites were measured as a function of age using a transverse strength test. Bond strength between layers decreased with the age of the initial layer and reflected the setting curves of the composites. The highly-filled composites exhibited the greatest bond strengths. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630101501
更新日期:1984-10-01 00:00:00