Abstract:
:The purpose of this study was to investigate the mechanism of surface layer formation in artificial white spots. Two nondestructive nuclear micro-analysis techniques were employed to analyze windows of human dental enamel at progressive stages of an artificial lesion. Fluoride concentrations were measured to a depth of 9 micron using resonant reaction profiling. Surface concentrations of Ca, P, Zn, Fe, and Sr were measured using proton-induced X-ray emission. The enamel windows were analyzed longitudinally after zero, four, and 16 hours' exposure to lactic acid gels of pH 3.7 and pH 4.5. During the first four hr of lesion formation, nonfluoridated apatite was preferentially removed from the surface with up to a 40% loss of Ca and P, depending on the gel pH. The next 12 hr saw a build-up of Ca and P in the surface to values approaching those of healthy enamel. In comparison, F and Sr concentrations changed very little, Fe tended to show a small increase at the end of each demineralization period, and Zn was less readily lost and gained than was Ca. These results and others suggest that the white spot surface layer phenomenon is a combined demineralization/remineralization process aided by, but not requiring, the presence of endogenous fluoride.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Crawford AW,de Bruin HJdoi
10.1177/00220345830620091001subject
Has Abstractpub_date
1983-09-01 00:00:00pages
964-8issue
9eissn
0022-0345issn
1544-0591journal_volume
62pub_type
杂志文章abstract::Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610091301
更新日期:1982-09-01 00:00:00
abstract::Adenoviral vectors effectively transfer genes to rat salivary glands. However, potent immune responses limit their use in vivo. Mice offer more opportunities than rats for the study of these immune processes. We first established conditions for infection of mouse salivary glands, with an adenoviral vector. The effects...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790020201
更新日期:2000-02-01 00:00:00
abstract::Antimicrobial agents, delivered either by mouthrinse or toothpaste, can be used to maintain plaque at levels compatible with oral health by (a) reducing existing plaque, (b) preventing the formation of new plaque, (c) selectively inhibiting those particular bacteria that are associated with disease, and (d) inhibiting...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345920710071501
更新日期:1992-07-01 00:00:00
abstract::In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and dif...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516653085
更新日期:2016-10-01 00:00:00
abstract::As the use of adhesive restorative materials has increased during the last several years, interest in adhesive materials that release fluoride has also grown. The purpose of this study was to measure fluoride release from several adhesive restorative materials and to evaluate its effect on dentin resistance to deminer...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780101001
更新日期:1999-10-01 00:00:00
abstract::We evaluated the predictive and construct validity of a caries activity assessment system associated with the International Caries Detection and Assessment System (ICDAS) in primary teeth. A total of 469 children were reexamined: participants of a caries survey performed 2 yr before (follow-up rate of 73.4%). At basel...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514531017
更新日期:2014-07-01 00:00:00
abstract::The human temporalis and masseter muscles are not activated homogeneously during static bite force tasks. In this study, we studied the possible existence of regional differences in these muscles under dynamic conditions. Electromyographic (EMG) activity was recorded by means of bipolar fine-wire electrodes. Six elect...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740061201
更新日期:1995-06-01 00:00:00
abstract::Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated os...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514557672
更新日期:2015-01-01 00:00:00
abstract::The expression of two matrix glycoproteins, tenascin and cellular fibronectin (cFN), has been studied in fully developed human permanent teeth, periodontal ligament, and alveolar bone, in both frozen and paraffin-processed material. Polyclonal antibodies to tenascin and a monoclonal antibody recognizing the ED sequenc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700010201
更新日期:1991-01-01 00:00:00
abstract::The expired air of a group of 48 persons, 40 with and eight without dental amalgam restorations, was analyzed for its mercury content before and after chewing. Expired air samples were collected in polyethylene bags, and a known quantity of each was pumped into the mercury detector for measurement. The results showed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600090601
更新日期:1981-09-01 00:00:00
abstract::Application of an incisal bite plane for as little as three d caused a significant increase in the size of the sublingual glands of rats, with some evidence of hyperplasia and hypertrophy of the acinar cells. The enlargement had few effects on salivary secretion, and the gland changes were reversible. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620060501
更新日期:1983-06-01 00:00:00
abstract::Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630061001
更新日期:1984-06-01 00:00:00
abstract::An adhesive opaque resin for veneering on cast metal was developed with 4-methacryloxyethyl trimellitate anhydride and poly (methyl methacrylate)-coated titanium dioxide prepared by aqueous phase polymerization. The opaque resin was a modified 4-META/MMA-TBB resin. The powder consisted of 20% of the encapsulated mater...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670010501
更新日期:1988-01-01 00:00:00
abstract::Dental caries is a microbially mediated disease that can result in significant tooth structure degradation. Although the preponderance of lesions is treated by surgical intervention, various strategies have been developed for its noninvasive management. Here, we use a novel approach for noninvasive treatment based on ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515619370
更新日期:2016-03-01 00:00:00
abstract::In previous studies, light-cured glass-ionomer cements have been shown to evoke cytotoxic reactions. It was the purpose of this investigation (a) to determine the nature of the ingredients released into an aqueous medium from 2 light-cured glass-ionomer cements (GICs) and 3 compomers; (b) to evaluate the cytotoxicity ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345980770121001
更新日期:1998-12-01 00:00:00
abstract::The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510381903
更新日期:2010-12-01 00:00:00
abstract::Investigations of the maturation pattern of rat incisor enamel by quantitative electron microscopy and electron-probe microanalysis indicate that mineralization of rat enamel can be regarded, as in humans, as a regular and progressive process pattern of enamel matrix formation. The species variations that have been pr...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580024201
更新日期:1979-03-01 00:00:00
abstract::Three strain combinations of in-bred mice representing strong and moderate histocompatibility barriers were used to determine if tooth allotransplants evoked strong or weak immunologic memory as measured by the second-set donor-strain skin graft technique. At issue was whether the anatomic site of engraftment could in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630010901
更新日期:1984-01-01 00:00:00
abstract::Diabetes mellitus is associated with depression of natural defenses against infection and increases the risk of periodontal disease. However, the effects of diabetes on periradicular tissue, which differs structurally from periodontal tissue, are not known. In this study, we evaluated the effects of type 2 diabetes on...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200416
更新日期:2003-04-01 00:00:00
abstract::Oxygen inhibits free radical polymerization and yields polymers with uncured surfaces. This is a concern when thin layers of resin are being polymerized, or in circumstances where conventional means of eliminating inhibition are inappropriate. In this study, we tested the hypothesis that viscosity, filler content, and...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508400808
更新日期:2005-08-01 00:00:00
abstract::It has often been hypothesized that a large tongue leads to an enlargement of the mandible and therefore contributes to the development of mandibular prognathism. We examined (1) whether the tongue volume in human subjects with mandibular prognathism was larger than that in subjects with good occlusion and (2) whether...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750120701
更新日期:1996-12-01 00:00:00
abstract::The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Variation in pulpal hemodynamics was attained by means of close intra-arterial injections of adrenergic agonists (NE ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/002203458506400415
更新日期:1985-04-01 00:00:00
abstract::Symphyseal secondary cartilage is important for mandibular development, but the molecular mechanisms underlying its formation remain largely unknown. Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage development and growth. By embryonic days 16.5 to 18.5, Sox9-expressing chondrocytes formed wi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510397836
更新日期:2011-05-01 00:00:00
abstract::During amelogenesis in the rat incisor, modulating ruffle-ended (RA) and smooth-ended (SA) ameloblasts are distributed as bands in the enamel organ of the maturation zone. This distribution of the two cell types has been shown to be precisely correlated with a banding of the underlying enamel, as shown by staining and...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680020101
更新日期:1989-02-01 00:00:00
abstract::The effects of Escherichia coli endotoxin upon mouse L929 cell proliferation, DNA synthesis, protein synthesis, and proline incorporation were determined. It was found that a level of endotoxin which inhibited cell proliferation prompted a similar inhibition of DNA synthesis and overall cell protein synthesis. In cont...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580061301
更新日期:1979-06-01 00:00:00
abstract::The classic stimulus for cellular cytokine production is bacterial lipopolysaccharide (endotoxin). It was therefore hypothesized that tumor necrosis factor-alpha (TNF-alpha) may be responsible for pericoronitis. TNF-alpha and its receptors were detected by immunohistochemical staining in third molar pericoronitis in t...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508401216
更新日期:2005-12-01 00:00:00
abstract::A new type of hydraulic cement has been developed. This cement consists of a mixture of cement powder and setting agent powder and therefore has only to be kneaded with a little amount of water when being used. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580050601
更新日期:1979-05-01 00:00:00
abstract::Selected strains of oral bacteria were analyzed for their ability to degrade wheat starch, maltose, maltotriose, and maltoheptaose. S. sanguis IUOM-11M and JC804, S. mutans 6715, S. salivarius IUOM-8, A. viscosus IUOM-62, and A. naeslundii ATCC 12104 degraded all four substrates. S. mutans NCTC 10449 degraded starch, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670011501
更新日期:1988-01-01 00:00:00
abstract::Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regenerati...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517691507
更新日期:2017-05-01 00:00:00
abstract::Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose be...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600818
更新日期:2007-08-01 00:00:00